Search Results - "Goderie, Susan K."

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids by Bowles, Kathryn R., Silva, M. Catarina, Whitney, Kristen, Bertucci, Taylor, Berlind, Joshua E., Lai, Jesse D., Garza, Jacob C., Boles, Nathan C., Mahali, Sidhartha, Strang, Kevin H., Marsh, Jacob A., Chen, Cynthia, Pugh, Derian A., Liu, Yiyuan, Gordon, Ronald E., Goderie, Susan K., Chowdhury, Rebecca, Lotz, Steven, Lane, Keith, Crary, John F., Haggarty, Stephen J., Karch, Celeste M., Ichida, Justin K., Goate, Alison M., Temple, Sally

“…Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms…”
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Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells by Shen, Qin, Goderie, Susan K., Jin, Li, Karanth, Nithin, Sun, Yu, Abramova, Natalia, Vincent, Peter, Pumiglia, Kevin, Temple, Sally

“…Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood…”
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Asymmetric Distribution of EGFR Receptor during Mitosis Generates Diverse CNS Progenitor Cells by Sun, Yu, Goderie, Susan K., Temple, Sally

“…It has been debated whether asymmetric distribution of cell surface receptors during mitosis could generate asymmetric cell divisions by yielding daughters…”
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Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche by Apostolopoulou, Maria, Kiehl, Thomas R., Winter, Mark, Cardenas De La Hoz, Edgar, Boles, Nathan C., Bjornsson, Christopher S., Zuloaga, Kristen L., Goderie, Susan K., Wang, Yue, Cohen, Andrew R., Temple, Sally

“…Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by…”
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Computational Image Analysis Reveals Intrinsic Multigenerational Differences between Anterior and Posterior Cerebral Cortex Neural Progenitor Cells by Winter, Mark R., Liu, Mo, Monteleone, David, Melunis, Justin, Hershberg, Uri, Goderie, Susan K., Temple, Sally, Cohen, Andrew R.

“…Time-lapse microscopy can capture patterns of development through multiple divisions for an entire clone of proliferating cells. Images are taken every few…”
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Automated Cell Lineage Construction: A Rapid Method to Analyze Clonal Development Established with Murine Neural Progenitor Cells by Al-Kofahi, Omar, Radke, Richard J., Goderie, Susan K., Shen, Qin, Temple, Sally, Roysam, Badrinath

“…Understanding cell lineage relationships is fundamental to understanding development, and can shed light on disease etiology and progression. We present a…”
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Multipotent embryonic spinal cord stem cells expanded by endothelial factors and Shh/RA promote functional recovery after spinal cord injury by Lowry, Natalia, Goderie, Susan K., Adamo, Matthew, Lederman, Patricia, Charniga, Carol, Gill, Jasrai, Silver, Jerry, Temple, Sally

“…Cell transplantation is a promising way to treat spinal cord injury and neurodegenerative disorders. Neural stem cells taken from the embryonic spinal cord are…”
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Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions by Shen, Qin, Wang, Yue, Kokovay, Erzsebet, Lin, Gang, Chuang, Shu-Mien, Goderie, Susan K, Roysam, Badrinath, Temple, Sally

“…There is an emerging understanding of the importance of the vascular system within stem cell niches. Here, we examine whether neural stem cells (NSCs) in the…”
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Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells by Abramova, Natalia, Charniga, Carol, Goderie, Susan K., Temple, Sally

“…Neural progenitor cells can be derived from a variety of developmental stages when they are preferentially proliferating, undergoing neurogenesis or undergoing…”
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STAU2 binds a complex RNA cargo that changes temporally with production of diverse intermediate progenitor cells during mouse corticogenesis by Chowdhury, Rebecca, Wang, Yue, Campbell, Melissa, Goderie, Susan K., Doyle, Francis, Tenenbaum, Scott A., Kusek, Gretchen, Kiehl, Thomas R., Ansari, Suraiya A., Boles, Nathan C., Temple, Sally

“…ABSTRACT STAU2 is a double-stranded RNA-binding protein enriched in the nervous system. During asymmetric divisions in the developing mouse cortex, STAU2…”
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Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol by Glasauer, Stella M.K., Goderie, Susan K., Rauch, Jennifer N., Guzman, Elmer, Audouard, Morgane, Bertucci, Taylor, Joy, Shona, Rommelfanger, Emma, Luna, Gabriel, Keane-Rivera, Erica, Lotz, Steven, Borden, Susan, Armando, Aaron M., Quehenberger, Oswald, Temple, Sally, Kosik, Kenneth S.

“…Mutations in the MAPT gene that encodes tau lead to frontotemporal dementia (FTD) with pathology evident in both cerebral neurons and glia. Human cerebral…”
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Vertebrate neural stem cell segmentation, tracking and lineaging with validation and editing by Winter, Mark, Wait, Eric, Roysam, Badrinath, Goderie, Susan K, Ali, Rania Ahmed Naguib, Kokovay, Erzsebet, Temple, Sally, Cohen, Andrew R

“…This protocol and the accompanying software program called LEVER (lineage editing and validation) enable quantitative automated analysis of phase-contrast…”
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The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice by Lowry, Natalia, Goderie, Susan K, Lederman, Patricia, Charniga, Carol, Gooch, Michael R, Gracey, Kristina D, Banerjee, Akhilesh, Punyani, Supriya, Silver, Jerry, Kane, Ravi S, Stern, Jeffrey H, Temple, Sally

“…Abstract After spinal cord injury (SCI), loss of cells and damage to ascending and descending tracts can result in paralysis. Current treatments for SCI are…”
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FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells by Qian, Xueming, Davis, Andrew A., Goderie, Susan K., Temple, Sally

“…The embryonic cerebral cortex contains a population of stem-like founder cells capable of generating large, mixed clones of neurons and glia in vitro. We…”
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Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells by Qian, X, Goderie, S K, Shen, Q, Stern, J H, Temple, S

“…Using long-term, time-lapse video-microscopy, we investigated how single progenitor cells isolated from the early embryonic cerebral cortex produce neurons and…”
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Multisensory interface for 5D stem cell image volumes by Koerner, Michael, Wait, Eric, Winter, Mark, Bjornsson, Chris, Kokovay, Erzsebet, Wang, Yue, Goderie, Susan K., Temple, Sally, Cohen, Andrew R.

“…Biological imaging of live cell and tissue using 3D microscopy is able to capture time-lapse image sequences showing multiple molecular markers labeling…”
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Timing of CNS Cell Generation: A Programmed Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells by Qian, Xueming, Shen, Qin, Goderie, Susan K., He, Wenlei, Capela, Alexandra, Davis, Andrew A., Temple, Sally

“…Multipotent stem cells that generate both neurons and glia are widespread components of the early neuroepithelium. During CNS development, neurogenesis largely…”
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Multipotent embryonic spinal cord stem cells expanded by endothelial factors and Shh/RA promote functional recovery after spinal cord injury: Spinal cord regeneration and repair by LOWRY, Natalia, GODERIE, Susan K, ADAMO, Matthew, LEDERMAN, Patricia, CHAMIGA, Carol, GILL, Jasrai, SILVER, Jerry, TEMPLE, Sally

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Timing of CNS Cell Generation by Qian, Xueming, Shen, Qin, Goderie, Susan K., He, Wenlei, Capela, Alexandra, Davis, Andrew A., Temple, Sally

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Use of 51Cr cell labelling to distinguish between release of radiolabelled amino acids from primary astrocyte cultures being due to efflux or cell damage by Kimelberg, H K, Bonville, D J, Goderie, S K

“…Continuous perfusion methods are widely used to monitor release of substances, particularly transmitters, from brain cell cultures growing as monolayers…”
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