Search Results - "Goddard, Katrina A.B"

Awareness and Utilization of BRCA1/2 Testing Among U.S. Primary Care Physicians by Bellcross, Cecelia A., PhD, Kolor, Katherine, PhD, Goddard, Katrina A.B., PhD, Coates, Ralph J., PhD, Reyes, Michele, PhD, Khoury, Muin J., MD, PhD

“…Background Testing for mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 ( BRCA ) has been commercially available since 1996…”
Get full text

Identifying patients with Lynch syndrome using a universal tumor screening program in an integrated healthcare system by Crain, Philip R, Zepp, Jamilyn M, Gille, Sara, Jenkins, Lindsay, Kauffman, Tia L, Shuster, Elizabeth, Goddard, Katrina A B, Wilfond, Benjamin S, Hunter, Jessica Ezzell

“…Lynch syndrome (LS) is associated with an increased risk of colorectal (CRC) and endometrial (EC) cancers. Universal tumor screening (UTS) of all individuals…”
Get full text

It's complicated: criteria for policy decisions for the clinical integration of genome‐scale sequencing for reproductive decision making by Wilfond, Benjamin S., Goddard, Katrina A.B.

“…The integration of genome scale sequencing into clinical practice for reproductive decision making raises similar policy issues for carrier testing for cystic…”
Get full text

The evolving landscape of expanded carrier screening: challenges and opportunities by Kraft, Stephanie A., Duenas, Devan, Wilfond, Benjamin S., Goddard, Katrina A. B.

“…Carrier screening allows individuals to learn their chance of passing on an autosomal or X-linked condition to their offspring. Initially introduced as…”
Get full text

Establishing the Medical Actionability of Genomic Variants by Goddard, Katrina A.B, Lee, Kristy, Buchanan, Adam H, Powell, Bradford C, Hunter, Jessica Ezzell

“…Actionability is an important concept in medicine that does not have a well-accepted standard definition, nor is there a general consensus on how to establish…”
Get full text

Preconception Carrier Screening by Genome Sequencing: Results from the Clinical Laboratory by Punj, Sumit, Akkari, Yassmine, Huang, Jennifer, Yang, Fei, Creason, Allison, Pak, Christine, Potter, Amiee, Dorschner, Michael O., Nickerson, Deborah A., Robertson, Peggy D., Jarvik, Gail P., Amendola, Laura M., Schleit, Jennifer, Simpson, Dana Kostiner, Rope, Alan F., Reiss, Jacob, Kauffman, Tia, Gilmore, Marian J., Himes, Patricia, Wilfond, Benjamin, Goddard, Katrina A.B., Richards, C. Sue

“…Advances in sequencing technologies permit the analysis of a larger selection of genes for preconception carrier screening. The study was designed as a…”
Get full text

Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer by Cross, Deanna S., Rahm, Alanna Kulchak, Kauffman, Tia L., Webster, Jennifer, Le, Anh Quynh, Spencer Feigelson, Heather, Alexander, Gwen, Meier, Paul, Onitilo, Adedayo A., Pawloski, Pamala A., Williams, Andrew E., Honda, Stacey, Daida, YeeHwa, McCarty, Catherine A., Goddard, Katrina A.B.

“…The aim of this study was to examine Lynch syndrome screening of patients with metastatic colorectal cancer in integrated health-care-delivery organizations…”
Get full text

Design of a randomized controlled trial for genomic carrier screening in healthy patients seeking preconception genetic testing by Kauffman, Tia L, Wilfond, Benjamin S, Jarvik, Gail P, Leo, Michael C, Lynch, Frances L, Reiss, Jacob A, Sue Richards, C, McMullen, Carmit, Nickerson, Deborah, Dorschner, Michael O, Goddard, Katrina A.B

“…Abstract Population-based carrier screening is limited to well-studied or high-impact genetic conditions for which the benefits may outweigh the associated…”
Get full text

Description and pilot results from a novel method for evaluating return of incidental findings from next-generation sequencing technologies by Goddard, Katrina A.B., Whitlock, Evelyn P., Berg, Jonathan S., Williams, Marc S., Webber, Elizabeth M., Webster, Jennifer A., Lin, Jennifer S., Schrader, Kasmintan A., Campos-Outcalt, Doug, Offit, Kenneth, Feigelson, Heather Spencer, Hollombe, Celine

“…The aim of this study was to develop, operationalize, and pilot test a transparent, reproducible, and evidence-informed method to determine when to report…”
Get full text

Participant Reactions to a Literacy-Focused, Web-Based Informed Consent Approach for a Genomic Implementation Study by Kraft, Stephanie A., Porter, Kathryn M., Duenas, Devan M., Guerra, Claudia, Joseph, Galen, Lee, Sandra Soo-Jin, Shipman, Kelly J., Allen, Jake, Eubanks, Donna, Kauffman, Tia L., Lindberg, Nangel M., Anderson, Katherine, Zepp, Jamilyn M., Gilmore, Marian J., Mittendorf, Kathleen F., Shuster, Elizabeth, Muessig, Kristin R., Arnold, Briana, Goddard, Katrina A.B, Wilfond, Benjamin S.

“…Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can…”
Get full text

The NextGen Study: patient motivation for participation in genome sequencing for carrier status by Kauffman, Tia L., Irving, Stephanie A., Leo, Michael C., Gilmore, Marian J., Himes, Patricia, McMullen, Carmit K., Morris, Elissa, Schneider, Jennifer, Wilfond, Benjamin S., Goddard, Katrina A. B.

“…Background While translational genomic sequencing research is increasing, few studies have been limited to healthy individuals; most have focused on patients…”
Get full text

Building the evidence base for decision making in cancer genomic medicine using comparative effectiveness research by Goddard, Katrina A.B., Knaus, William A., Whitlock, Evelyn, Lyman, Gary H., Feigelson, Heather Spencer, Schully, Sheri D., Ramsey, Scott, Tunis, Sean, Freedman, Andrew N., Khoury, Muin J., Veenstra, David L.

“…The clinical utility is uncertain for many cancer genomic applications. Comparative effectiveness research (CER) can provide evidence to clarify this…”
Get full text

A Familial Alzheimer's Disease Locus on Chromosome I by Levy-Lahad, Ephrat, Wijsman, Ellen M., Nemens, Ellen, Anderson, Leojean, Katrina A. B. Goddard, Weber, James L., Bird, Thomas D., Schellenberg, Gerard D.

“…The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci…”
Get full text

Stakeholder assessment of the evidence for cancer genomic tests: insights from three case studies by Deverka, Patricia A., Schully, Sheri D., Ishibe, Naoko, Carlson, Josh J., Freedman, Andrew, Goddard, Katrina A.B., Khoury, Muin J., Ramsey, Scott D.

“…Insufficient evidence on the net benefits and harms of genomic tests in real-world settings is a translational barrier for genomic medicine. Understanding…”
Get full text

Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes by Goddard, Katrina A B, Tromp, Gerard, Romero, Roberto, Olson, Jane M, Lu, Qing, Xu, Zhiying, Parimi, Neeta, Nien, Jyh Kae, Gomez, Ricardo, Behnke, Ernesto, Solari, Margarita, Espinoza, Jimmy, Santolaya, Joaquin, Chaiworapongsa, Tinnakorn, Lenk, Guy M, Volkenant, Kimberly, Anant, Madan Kumar, Salisbury, Benjamin A, Carr, Janet, Lee, Min Soeb, Vovis, Gerald F, Kuivaniemi, Helena

“…Pre-eclampsia (PE) affects 5-7% of pregnancies in the US, and is a leading cause of maternal death and perinatal morbidity and mortality worldwide. To identify…”
Get more information

Identification of Evidence-Based Biospecimen Quality-Control Tools by Betsou, Fotini, Gunter, Elaine, Clements, Judith, DeSouza, Yvonne, Goddard, Katrina A.B, Guadagni, Fiorella, Yan, Wusheng, Skubitz, Amy, Somiari, Stella, Yeadon, Trina, Chuaqui, Rodrigo

“…Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample…”
Get full text

Lessons learned about harmonizing survey measures for the CSER consortium by Goddard, Katrina A B, Angelo, Frank A N, Ackerman, Sara L, Berg, Jonathan S, Biesecker, Barbara B, Danila, Maria I, East, Kelly M, Hindorff, Lucia A, Horowitz, Carol R, Hunter, Jessica Ezzell, Joseph, Galen, Knight, Sara J, McGuire, Amy, Muessig, Kristin R, Ou, Jeffrey, Outram, Simon, Rahn, Elizabeth J, Ramos, Michelle A, Rini, Christine, Robinson, Jill O, Smith, Hadley Stevens, Waltz, Margaret, Lee, Sandra Soo-Jin

“…Implementation of genome-scale sequencing in clinical care has significant challenges: the technology is highly dimensional with many kinds of potential…”
Get full text

Universal Screen for Lynch Syndrome in an Integrated Health Care System: Assessment of Patient Perspectives and Sharing Results With At-Risk Relatives by Peterson, Susan K, Wiesner, Georgia L, Reiss, Jacob A, Goddard, Katrina A.B, Muessig, Kristin R, Hunter, Jessica Ezzell, Davis, James V, Zepp, Jamilyn M, Bergen, Kellene M, Acheson, Louise S, Syngal, Sapna

“…Background/Aims: Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC). Evidence-based recommendations promote universal tumor…”
Get full text

Association of kallikrein gene polymorphisms with intracranial aneurysms by Weinsheimer, Shantel, Goddard, Katrina A B, Parrado, Antonio R, Lu, Qing, Sinha, Moumita, Lebedeva, Elena R, Ronkainen, Antti, Niemelä, Mika, Khusnutdinova, Elza K, Khusainova, Rita I, Helin, Katariina, Jääskeläinen, Juha E, Sakovich, Vladimir P, Land, Susan, Kuivaniemi, Helena, Tromp, Gerard

“…Genomewide DNA linkage analysis identified a susceptibility locus for intracranial aneurysm (IA) on chromosome 19q13 in the Finnish population, a region…”
Get full text

Advancing Implementation Science in Cancer Genomics: Progressing from Discovery to Population Health Benefit by Chambers, David A., Goddard, Katrina A.B.

Get full text