Search Results - "Godbold, Gene D"

SeqScreen: accurate and sensitive functional screening of pathogenic sequences via ensemble learning by Balaji, Advait, Kille, Bryce, Kappell, Anthony D, Godbold, Gene D, Diep, Madeline, Elworth, R A Leo, Qian, Zhiqin, Albin, Dreycey, Nasko, Daniel J, Shah, Nidhi, Pop, Mihai, Segarra, Santiago, Ternus, Krista L, Treangen, Todd J

“…The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic…”
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Simulating transmission of ESKAPE pathogens plus C. difficile in relevant clinical scenarios by Weber, Katharina L, LeSassier, Danielle S, Kappell, Anthony D, Schulte, Kathleen Q, Westfall, Nicole, Albright, Nicolette C, Godbold, Gene D, Palsikar, Veena, Acevedo, Carlos A, Ternus, Krista L, Hewitt, F. Curtis

“…Abstract Background The prevalence of healthcare-acquired infections (HAI) and rising levels of antimicrobial resistance places significant economic and public…”
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Improved understanding of biorisk for research involving microbial modification using annotated sequences of concern by Godbold, Gene D, Hewitt, F Curtis, Kappell, Anthony D, Scholz, Matthew B, Agar, Stacy L, Treangen, Todd J, Ternus, Krista L, Sandbrink, Jonas B, Koblentz, Gregory D

“…Regulation of research on microbes that cause disease in humans has historically been focused on taxonomic lists of 'bad bugs'. However, given our increased…”
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Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis by Godbold, Gene D, Kappell, Anthony D, LeSassier, Danielle S, Treangen, Todd J, Ternus, Krista L

“…To identify sequences with a role in microbial pathogenesis, we assessed the adequacy of their annotation by existing controlled vocabularies and sequence…”
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Cell killing by the human parasite Entamoeba histolytica is inhibited by the Rho-inactivating C3 exoenzyme by Godbold, Gene D, Mann, Barbara J

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A Rho-like small GTPase of Entamoeba histolytica contains an unusual amino acid residue in a conserved GDP-stabilization region and is not a substrate for C3 exoenzyme by Godbold, Gene D, Corbett, Kevin D, Mann, Barbara J

“…The Entamoeba histolytica small GTP-binding protein EhRho1 has an unusual amino acid residue at a conserved site found in all known Ras superfamily proteins…”
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Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D by Godbold, G D, Ahn, K, Yeyeodu, S, Lee, L F, Ting, J P, Erickson, A H

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The pH-dependent membrane association of procathepsin L is mediated by a 9-residue sequence within the propeptide by MCINTYRE, G. F, GODBOLD, G. D, ERICKSON, A. H

“…The lysosomal proprotease procathepsin L binds to mouse fibroblast microsomal membranes at pH 5, but mature active cathepsin L does not (McIntyre, G.F., and…”
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