Search Results - "Goda, Yukiko"

Unraveling Mechanisms of Homeostatic Synaptic Plasticity by Pozo, Karine, Goda, Yukiko

“…Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic…”
Get full text

FINE-TUNING SYNAPTIC STRENGTHS IN LOCAL CIRCUITS by Goda, Yukiko

Get full text

The interplay between Hebbian and homeostatic synaptic plasticity by Vitureira, Nathalia, Goda, Yukiko

“…Synaptic plasticity, a change in the efficacy of synaptic signaling, is a key property of synaptic communication that is vital to many brain functions. Hebbian…”
Get full text

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy by Goda, Yukiko, Cingolani, Lorenzo A

“…Key Points Actin filaments are the major cytoskeletal elements of pre- and postsynaptic terminals. Actin exists in two states in the cell: as monomeric G-actin…”
Get full text

The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity by Chater, Thomas Edward, Goda, Yukiko

“…Neurotransmission is critically dependent on the number, position, and composition of receptor proteins on the postsynaptic neuron. Of these,…”
Get full text

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity by Chater, Thomas E, Goda, Yukiko

“…In the mammalian central nervous system, excitatory glutamatergic synapses harness neurotransmission that is mediated by ion flow through…”
Get full text

Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites by Letellier, Mathieu, Levet, Florian, Thoumine, Olivier, Goda, Yukiko

“…Neurons receive a large number of active synaptic inputs from their many presynaptic partners across their dendritic tree. However, little is known about how…”
Get full text

Homeostatic synaptic plasticity: from single synapses to neural circuits by Vitureira, Nathalia, Letellier, Mathieu, Goda, Yukiko

“…Highlights ► Homeostatic plasticity tunes presynaptic and postsynaptic strengths to altered activity. ► Matching of presynaptic and postsynaptic strengths uses…”
Get full text

Competitive processes shape multi-synapse plasticity along dendritic segments by Chater, Thomas E., Eggl, Maximilian F., Goda, Yukiko, Tchumatchenko, Tatjana

“…Neurons receive thousands of inputs onto their dendritic arbour, where individual synapses undergo activity-dependent plasticity. Long-lasting changes in…”
Get full text

Reflections on the past two decades of neuroscience by Bassett, Danielle S., Cullen, Kathleen E., Eickhoff, Simon B., Farah, Martha J., Goda, Yukiko, Haggard, Patrick, Hu, Hailan, Hurd, Yasmin L., Josselyn, Sheena A., Khakh, Baljit S., Knoblich, Jürgen A., Poirazi, Panayiota, Poldrack, Russell A., Prinz, Marco, Roelfsema, Pieter R., Spires-Jones, Tara L., Sur, Mriganka, Ueda, Hiroki R.

“…The first issue of Nature Reviews Neuroscience was published 20 years ago, in 2000. To mark this anniversary, in this Viewpoint article we asked a selection of…”
Get full text

Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids by Sawada, Tomoyo, Chater, Thomas E., Sasagawa, Yohei, Yoshimura, Mika, Fujimori-Tonou, Noriko, Tanaka, Kaori, Benjamin, Kynon J. M., Paquola, Apuã C. M., Erwin, Jennifer A., Goda, Yukiko, Nikaido, Itoshi, Kato, Tadafumi

“…Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms underlying schizophrenia and bipolar disorder remain poorly understood. Recent…”
Get full text

The actin cytoskeleton : Integrating form and function at the synapse by DILLON, Christian, GODA, Yukiko

“…Synapses are highly specialized intercellular junctions that mediate the transmission of information between axons and target cells. A fundamental property of…”
Get full text

Heterosynaptic cross-talk of pre- and postsynaptic strengths along segments of dendrites by Tong, Rudi, Chater, Thomas Edward, Emptage, Nigel John, Goda, Yukiko

“…Dendrites are crucial for integrating incoming synaptic information. Individual dendritic branches are thought to constitute a signal processing unit, yet how…”
Get full text

Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum by Chipman, Peter H, Fung, Chi Chung Alan, Pazo Fernandez, Alejandra, Sawant, Abhilash, Tedoldi, Angelo, Kawai, Atsushi, Ghimire Gautam, Sunita, Kurosawa, Mizuki, Abe, Manabu, Sakimura, Kenji, Fukai, Tomoki, Goda, Yukiko

“…Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from…”
Get full text

Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks by Letellier, Mathieu, Park, Yun Kyung, Chater, Thomas E., Chipman, Peter H., Gautam, Sunita Ghimire, Oshima-Takago, Tomoko, Goda, Yukiko

“…Dendrites are neuronal structures specialized for receiving and processing information through their many synaptic inputs. How input strengths are modified…”
Get full text

Local Dendritic Activity Sets Release Probability at Hippocampal Synapses by Branco, Tiago, Staras, Kevin, Darcy, Kevin J., Goda, Yukiko

“…The arrival of an action potential at a synapse triggers neurotransmitter release with a limited probability, p r . Although p r is a fundamental parameter in…”
Get full text

How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders by Hui, Kelvin K, Chater, Thomas E, Goda, Yukiko, Tanaka, Motomasa

“…Excitatory-inhibitory (E-I) imbalance has been shown to contribute to the pathogenesis of a wide range of neurodevelopmental disorders including autism…”
Get full text

Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins by Cingolani, Lorenzo A., Thalhammer, Agnes, Yu, Lily M.Y., Catalano, Myriam, Ramos, Timothy, Colicos, Michael A., Goda, Yukiko

“…At synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating signaling events across the synaptic cleft. Among synaptic CAMs,…”
Get full text

Synaptophysin Regulates Activity-Dependent Synapse Formation in Cultured Hippocampal Neurons by Tarsa, Leila, Goda, Yukiko

“…Synaptophysin is an abundant synaptic vesicle protein without a definite synaptic function. Here, we examined a role for synaptophysin in synapse formation in…”
Get full text

The X-Linked Intellectual Disability Protein TSPAN7 Regulates Excitatory Synapse Development and AMPAR Trafficking by Bassani, Silvia, Cingolani, Lorenzo A., Valnegri, Pamela, Folci, Alessandra, Zapata, Jonathan, Gianfelice, Antonella, Sala, Carlo, Goda, Yukiko, Passafaro, Maria

“…Mutations in TSPAN7—a member of the tetraspanin protein superfamily—are implicated in some forms of X-linked intellectual disability. Here we show that TSPAN7…”
Get full text