Search Results - "Gocher, Angela M"

Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment by Scott, Ellen N, Gocher, Angela M, Workman, Creg J, Vignali, Dario A A

“…Regulatory T cells (T ) are key immunosuppressive cells that promote tumor growth by hindering the effector immune response. T utilize multiple suppressive…”
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Interferon-γ: teammate or opponent in the tumour microenvironment? by Gocher, Angela M., Workman, Creg J., Vignali, Dario A. A.

“…Cancer immunotherapy offers substantive benefit to patients with various tumour types, in some cases leading to complete tumour clearance. However, many…”
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Distinguishing parallel from series circuits with a double knockdown procedure in human cell lines by Gocher-Demske, Angela M., Dai, Shuhang, Edelman, Arthur M.

“…Signaling cascades can act in series or in parallel. Here, we describe a convenient and robust protocol for dual, sequential knockdown of two proteins using…”
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Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells by Gocher, Angela M., Azabdaftari, Gissou, Euscher, Lindsey M., Dai, Shuhang, Karacosta, Loukia G., Franke, Thomas F., Edelman, Arthur M.

“…Hyperactivation of Akt is associated with oncogenic changes in the growth, survival, and chemoresistance of cancer cells. The PI3K/phosphoinositide-dependent…”
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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity by Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., John Wherry, E., Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

“…Robust CD8 + T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory…”
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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment by Bender, Mackenzie J., McPherson, Alex C., Phelps, Catherine M., Pandey, Surya P., Laughlin, Colin R., Shapira, Jake H., Medina Sanchez, Luzmariel, Rana, Mohit, Richie, Tanner G., Mims, Tahliyah S., Gocher-Demske, Angela M., Cervantes-Barragan, Luisa, Mullett, Steven J., Gelhaus, Stacy L., Bruno, Tullia C., Cannon, Nikki, McCulloch, John A., Vignali, Dario A.A., Hinterleitner, Reinhard, Joglekar, Alok V., Pierre, Joseph F., Lee, Sonny T.M., Davar, Diwakar, Zarour, Hassane M., Meisel, Marlies

“…The use of probiotics by cancer patients is increasing, including among those undergoing immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a…”
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Nucleoporin 62 and Ca(2+)/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G, Kuroski, Laura A, Hofmann, Wilma A, Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M, Dai, Shuhang, Hoste, Allen J, Edelman, Arthur M

“…Re-activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen-responsive to…”
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Nucleoporin 62 and Ca2+/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G., Kuroski, Laura A., Hofmann, Wilma A., Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M., Dai, Shuhang, Hoste, Allen J., Edelman, Arthur M.

“…BACKGROUND Re‐activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen‐responsive to…”
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Catch and release: freeing up PD-L1 ameliorates autoimmunity by Grebinoski, Stephanie, Gocher-Demske, Angela M., Vignali, Dario A. A.

“…The binding of PD-L1 to CD80 on antigen-presenting cells prevents PD-1 ligation on T cells. Therapeutic blockade of the cis -PD-L1–CD80 interaction liberates…”
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Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells by Dai, Shuhang, Venturini, Elisa, Yadav, Saveg, Lin, Xiaoxuan, Clapp, Dylan, Steckiewicz, Martin, Gocher-Demske, Angela M, Hardie, D Grahame, Edelman, Arthur M

“…Engagement of epidermal growth factor (EGF) with its receptor (EGFR) produces a broad range of cancer phenotypes. The overriding aim of this study was to…”
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IFNγ-induction of TH1-like regulatory T cells controls antiviral responses by Gocher-Demske, Angela M., Cui, Jian, Szymczak-Workman, Andrea L., Vignali, Kate M., Latini, Julianna N., Pieklo, Gwen P., Kimball, Jesse C., Avery, Lyndsay, Cipolla, Ellyse M., Huckestein, Brydie R., Hedden, Lee, Meisel, Marlies, Alcorn, John F., Kane, Lawrence P., Workman, Creg J., Vignali, Dario A. A.

“…Regulatory T (T reg ) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from…”
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Abstract 1430: CaMKK2 regulates EGF-dependent activation of oncogenic Akt in ovarian cancer cells by Dai, Shuhang, Gocher, Angela M., Edelman, Arthur M.

“…Background-The canonical PI3K/Akt pathway is hyperactive in a variety of cancers including ovarian cancer (OVCa). Using baculovirus-expressed, FPLC-purified…”
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Neuropilin-1 is a T cell memory checkpoint limiting long-term anti-tumor immunity by Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., Wherry, E. John, Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

“…Robust CD8 + T cell memory is essential for long-term protective immunity, but is often compromised in cancer where T cell exhaustion leads to loss of memory…”
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IFNγ guides the suppressive activity of T reg cells during viral infection

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Abstract A12: Regulation of ovarian cancer OVCAR-3 cell proliferation and viability by calcium/calmodulin-dependent protein kinase kinase 2 by Gocher, Angela M., Azabdaftari, Gissou, Edelman, Arthur M.

“…Protein kinases play crucial roles in cancer progression and are considered potential targets for novel anti-cancer therapeutics. Oncogenic kinases mediate a…”
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Abstract B13: Regulation of Akt activity, cell proliferation, and viability in ovarian cancer cells by calcium/calmodulin-dependent protein kinase kinase 2 by Gocher, Angela M., Franke, Thomas F., Azabdaftari, Gissou, Karacosta, Loukia G., Edelman, Arthur M.

“…Calcium/Calmodulin-dependent protein kinase kinase 2 (CaMKK2) has been implicated in the regulation of G1/S phase cell cycle progression in prostate and breast…”
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Nucleoporin 62 and Ca super(2+)/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G, Kuroski, Laura A, Hofmann, Wilma A, Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M, Dai, Shuhang, Hoste, Allen J, Edelman, Arthur M

“…BACKGROUND Re-activation of the transcriptional activity of the androgen receptor (AR) is an important factor mediating progression from androgen-responsive to…”
Get full text

Nucleoporin 62 and Ca 2+ /calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells by Karacosta, Loukia G., Kuroski, Laura A., Hofmann, Wilma A., Azabdaftari, Gissou, Mastri, Michalis, Gocher, Angela M., Dai, Shuhang, Hoste, Allen J., Edelman, Arthur M.

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Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Phosphorylates and Activates Oncogenic Akt in Ovarian Cancer Cells by Gocher, Angela M

“…Hyperactivation of Akt is associated with oncogenic changes in the growth, survival and chemoresistance of cancer cells. The growth factor-dependent…”
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Akt activation by Ca 2+ /calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells by Gocher, Angela M, Azabdaftari, Gissou, Euscher, Lindsey M, Dai, Shuhang, Karacosta, Loukia G, Franke, Thomas F, Edelman, Arthur M

“…Hyperactivation of Akt is associated with oncogenic changes in the growth, survival, and chemoresistance of cancer cells. The PI3K/phosphoinositide-dependent…”
Get full text