Search Results - "Gocek, Elzbieta"

Cardiovascular risk and metabolic profile of Polish citizens from Lower Silesia. First signs of metabolic crisis? by Kozera, Lukasz, Kuliczkowski, Wiktor, Gocek, Elzbieta

“…Population biobanks are essential for the development of public health screening and improvement of personalized medicine. Since 2012, Biobank of Łukasiewicz…”
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Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells by Gocek, Elzbieta, Moulas, Anargyros N., Studzinski, George P.

“…Abstract Protein tyrosine kinases (PTKs) are enzymes that transfer phosphate groups to tyrosine residues on protein substrates. Phosphorylation of proteins…”
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Differentiation therapy of acute myeloid leukemia by Gocek, Elzbieta, Marcinkowska, Ewa

“…Acute Myeloid Leukemia (AML) is a predominant acute leukemia among adults, characterized by accumulation of malignantly transformed immature myeloid…”
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The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy by Gocek, Elzbieta, Studzinski, George P

“…The current standard regimens for the treatment of acute myeloid leukemia (AML) are curative in less than half of patients; therefore, there is a great need…”
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Genes encoding transcription factors have self-control: How important is this for cell differentiation? by Gocek, Elzbieta, Ph.D, Studzinski, George P., M.D., Ph.D

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MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis by GOCEK, Elzbieta, XUENING WANG, XIUPING LIU, LIU, Chang-Gong, STUDZINSKI, George P

“…1,25-Dihydroxyvitamin D(3) (1,25D) used to treat human acute myeloid leukemia (AML) cells induces features of normal monocytes, but the mechanisms underlying…”
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Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3 by Wang, Xuening, Gocek, Elzbieta, Novik, Victoria, Harrison, Jonathan S., Danilenko, Michael, Studzinski, George P.

“…Acute myelogenous leukemia (AML) is a disease characterized by dysregulated cell proliferation associated with impaired cell differentiation, and current…”
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Regulation of Leukemic Cell Differentiation through the Vitamin D Receptor at the Levels of Intracellular Signal Transduction, Gene Transcription, and Protein Trafficking and Stability by Gocek, Elżbieta, Baurska, Hanna, Marchwicka, Aleksandra, Marcinkowska, Ewa

“…1α,25-Dihydroxyvitamin D3 (1,25(OH)2D) exerts its biological activities through vitamin D receptor (VDR), which is a member of the superfamily of steroid…”
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MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3 by Wang, Xuening, Gocek, Elzbieta, Liu, Chang-Gong, Studzinski, George P.

“…Human myeloid leukemia cells exposed to 1,25-dihydroxyvitamin D3 (1,25D), a major cancer chemopreventive agent, acquire features of normal monocytes and arrest…”
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NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells by Gocek, Elżbieta, Marchwicka, Aleksandra, Bujko, Kamila, Marcinkowska, Ewa

“…Acute myeloid leukemia (AML) cell lines can be driven to differentiate to monocyte-like cells by 1,25- dihydroxyvitamin D3 (1,25D) and to granulocyte-like…”
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DNA Repair in Despair-Vitamin D Is Not Fair by Gocek, Elżbieta, Studzinski, George P.

“…ABSTRACT The role of vitamin D as a treatment option for neoplastic diseases, once considered to have a bright future, remains controversial. The preclinical…”
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Opposite regulation of vitamin D receptor by ATRA in AML cells susceptible and resistant to vitamin D-induced differentiation by Gocek, Elżbieta, Marchwicka, Aleksandra, Baurska, Hanna, Chrobak, Agnieszka, Marcinkowska, Ewa

“…► We study effects of 1,25-dihydroxyvitamin D3 and of ATRA toward AML cell lines. ► KG-1 cells appear resistant to 1,25-dihydroxyvitamin D3, but susceptible to…”
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Activation of intracellular signaling pathways is necessary for an increase in VDR expression and its nuclear translocation by Gocek, Elżbieta, Kiełbiński, Marek, Marcinkowska, Ewa

“…1,25-Dihydroxyvitamin D 3 (1,25D) regulates gene transcription through the nuclear vitamin D receptor (VDR) and initiates rapid cellular responses via an…”
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Heat shock protein 90 interacts with vitamin D receptor in human leukemia cells by Marcinkowska, Ewa, Gocek, Elżbieta

“…The active form of vitamin D, 1α,25-dihydroxyvitamin D 3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR). Many…”
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Different susceptibilities to 1,25-dihydroxyvitamin D3 -induced differentiation of AML cells carrying various mutations by Gocek, Elżbieta, Kiełbiński, Marek, Baurska, Hanna, Haus, Olga, Kutner, Andrzej, Marcinkowska, Ewa

“…Abstract This study was designed to compare the differentiation-inducing potential of 1,25-dihydroxyvitamin D3 (1,25D) with some analogs (VDAs) in a panel of…”
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Different susceptibilities to 1,25-dihydroxyvitamin D 3-induced differentiation of AML cells carrying various mutations by Gocek, Elżbieta, Kiełbiński, Marek, Baurska, Hanna, Haus, Olga, Kutner, Andrzej, Marcinkowska, Ewa

“…This study was designed to compare the differentiation-inducing potential of 1,25-dihydroxyvitamin D 3 (1,25D) with some analogs (VDAs) in a panel of acute…”
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Vitamin D and differentiation in cancer by Gocek, Elzbieta, Studzinski, George P.

“…This paper reviews the current understanding of the vitamin D-induced differentiation of neoplastic cells, which results in the generation of cells that…”
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Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential by Gocek, Elżbieta, Kiełbiński, Marek, Wyłób, Paulina, Kutner, Andrzej, Marcinkowska, Ewa

“…1,25-Dihydroxyvitamin D 3 (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription…”
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ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells by Wang, Xuening, Pesakhov, Stella, Weng, Ashley, Kafka, Michael, Gocek, Elzbieta, Nguyen, Mai, Harrison, Jonathan S., Danilenko, Michael, Studzinski, George P.

“…•ERK5 inhibitors combined with 1,25D arrest proliferation and cell cycle in AML cells.•G1 and G2 cell cycle transitions are facilitated by ERK5…”
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NADPH-Cytochrome P450 Reductase Is Regulated by All-Trans Retinoic Acid and by 1,25-Dihydroxyvitamin D.sub.3 in Human Acute Myeloid Leukemia Cells by Gocek, Elzbieta, Marchwicka, Aleksandra, Bujko, Kamila, Marcinkowska, Ewa

“…Acute myeloid leukemia (AML) cell lines can be driven to differentiate to monocyte-like cells by 1,25- dihydroxyvitamin D.sub.3 (1,25D) and to granulocyte-like…”
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