Search Results - "Gobom, J"

Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease by Alawode, D. O. T., Heslegrave, A. J., Ashton, N. J., Karikari, T. K., Simrén, J., Montoliu‐Gaya, L., Pannee, J., O´Connor, A., Weston, P. S. J., Lantero‐Rodriguez, J., Keshavan, A., Snellman, A., Gobom, J., Paterson, R. W., Schott, J. M., Blennow, K., Fox, N. C., Zetterberg, H.

“…Alzheimer’s disease (AD) is increasingly prevalent worldwide, and disease‐modifying treatments may soon be at hand; hence, now, more than ever, there is a need…”
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Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics by Magdalinou, N.K, Noyce, A.J, Pinto, R, Lindstrom, E, Holmén-Larsson, J, Holtta, M, Blennow, K, Morris, H.R, Skillbäck, T, Warner, T.T, Lees, A.J, Pike, I, Ward, M, Zetterberg, H, Gobom, J

“…Abstract Introduction Neurodegenerative parkinsonian syndromes have significant clinical and pathological overlap, making early diagnosis difficult…”
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α-Cyano-4-hydroxycinnamic Acid Affinity Sample Preparation. A Protocol for MALDI-MS Peptide Analysis in Proteomics by Gobom, Johan, Schuerenberg, Martin, Mueller, Martin, Theiss, Dorothea, Lehrach, Hans, Nordhoff, Eckhard

“…We present a new MALDI sample preparation technique for peptide analysis using the matrix α-cyano-4-hydroxycinnamic acid (CHCA) and prestructured sample…”
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P.2.d.042 Identification and semi-quantification of potential biomarkers for bipolar disorder with a novel mass spectrometric methodology by Larsson, J. Holmén, Gobom, J, Jakobsson, J, Hölttä, M, Blennow, K, Zetterberg, H, Landén, M

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A CE−MALDI Interface Based on the Use of Prestructured Sample Supports by Johnson, Torbjörn, Bergquist, Jonas, Ekman, Rolf, Nordhoff, Eckhard, Schürenberg, Martin, Klöppel, Klaus-Dieter, Müller, Martin, Lehrach, Hans, Gobom, Johan

“…We have developed an off-line coupling of capillary electrophoresis (CE) to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry…”
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Identification of nuclei associated proteins by 2D-gel electrophoresis and mass spectrometry by Bergquist, Jonas, Gobom, Johan, Blomberg, Anders, Roepstorff, Peter, Ekman, Rolf

“…In clinical neuroscience as well as in many other clinical disciplines, the completion of the human genome project offers a new possibility to identify and…”
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Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease by Cicognola, Claudia, Brinkmalm, Gunnar, Wahlgren, Jessica, Portelius, Erik, Gobom, Johan, Cullen, Nicholas C., Hansson, Oskar, Parnetti, Lucilla, Constantinescu, Radu, Wildsmith, Kristin, Chen, Hsu-Hsin, Beach, Thomas G., Lashley, Tammaryn, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina

“…Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of…”
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Genome-scale metabolic network reconstruction of model animals as a platform for translational research by Wang, Hao, Robinson, Jonathan L., Kocabas, Pinar, Gustafsson, Johan, Anton, Mihail, Cholley, Pierre-Etienne, Huang, Shan, Gobom, Johan, Svensson, Thomas, Uhlen, Mattias, Zetterberg, Henrik, Nielsen, Jens

“…Genome-scale metabolic models (GEMs) are used extensively for analysis of mechanisms underlying human diseases and metabolic malfunctions. However, the lack of…”
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Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics by Tijms, Betty M, Gobom, Johan, Reus, Lianne, Jansen, Iris, Hong, Shengjun, Dobricic, Valerija, Kilpert, Fabian, Ten Kate, Mara, Barkhof, Frederik, Tsolaki, Magda, Verhey, Frans R J, Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Bertram, Lars, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie, Bos, Isabelle, Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E, Zetterberg, Henrik, Visser, Pieter Jelle

“…Alzheimer's disease is biologically heterogeneous, and detailed understanding of the processes involved in patients is critical for development of treatments…”
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Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers by Jansen, Iris E., van der Lee, Sven J., Gomez-Fonseca, Duber, de Rojas, Itziar, Zettergren, Anna, Mishra, Aniket, Bellenguez, Céline, Kleineidam, Luca, Küçükali, Fahri, Tesí, Niccolo, Vromen, Ellen M., Alvarez, Ignacio, Amouyel, Philippe, Athanasiu, Lavinia, Belbin, Olivia, Bergh, Sverre, Blennow, Kaj, Blesa, Rafael, Boada, Mercè, Boland, Anne, Buerger, Katharina, Carracedo, Ángel, Chene, Geneviève, Debette, Stephanie, Deleuze, Jean-Francois, Dols-Icardo, Oriol, Dufouil, Carole, Duron, Emmanuelle, Fladby, Tormod, Frölich, Lutz, Garcia-Martinez, Maria, Gobom, Johan, Grimmer, Timo, Haapasalo, Annakaisa, Hampel, Harald, Hanon, Olivier, Hausner, Lucrezia, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Hernández, Isabel, Herukka, Sanna-Kaisa, Holstege, Henne, Jarholm, Jonas, Koivisto, Anne M., Kornhuber, Johannes, Kuulasmaa, Teemu, Lage, Carmen, Laske, Christoph, Leinonen, Ville, Lewczuk, Piotr, Lleó, Alberto, Lopez-Garcia, Sara, Marquié, Marta, Mol, Merel O., Montrreal, Laura, Moreno, Fermin, Moreno-Grau, Sonia, Nicolas, Gael, Orellana, Adelina, Peters, Oliver, Pijnenburg, Yolande A. L., Popp, Julius, Priller, Josef, Puerta, Raquel, Quintela, Inés, Ramakers, Inez, Rodriguez-Rodriguez, Eloy, Saltvedt, Ingvild, Sanchez-Juan, Pascual, Scheltens, Philip, Scherbaum, Norbert, Schmid, Matthias, Selbæk, Geir, Shadrin, Alexey, Skoog, Ingmar, Soininen, Hilkka, Tárraga, Lluís, Tijms, Betty, Tsolaki, Magda, Van Broeckhoven, Christine, Van Dongen, Jasper, van Swieten, John C., Vandenberghe, Rik, Visser, Pieter J., Wagner, Michael, Wiltfang, Jens, Zetterberg, Henrik, Zulaica, Miren, van Duijn, Cornelia M., Engelborghs, Sebastiaan, Pastor, Pau, Hiltunen, Mikko, Ingelsson, Martin, Andreassen, Ole A., Clarimón, Jordi, Sleegers, Kristel, Ruiz, Agustín, Ramirez, Alfredo, Cruchaga, Carlos, Lambert, Jean-Charles

“…Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD)…”
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P.621 Exploring the cerebrospinal fluid proteome in bipolar disorder by Göteson, A., Holmén-Larsson, J., Gobom, J., Zetterberg, H., Blennow, K., Landén, M.

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Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease by Thorsell, Annika, Bjerke, Maria, Gobom, Johan, Brunhage, Eva, Vanmechelen, Eugeen, Andreasen, Niels, Hansson, Oskar, Minthon, Lennart, Zetterberg, Henrik, Blennow, Kaj

“…Abstract Synaptic pathology occurs early in Alzheimer's disease (AD) development, and cerebrospinal fluid biomarkers for synaptic damage may be altered early…”
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Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease by Visser, Pieter Jelle, Reus, Lianne M, Gobom, Johan, Jansen, Iris, Dicks, Ellen, van der Lee, Sven J, Tsolaki, Magda, Verhey, Frans R J, Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Freund-Levi, Yvonne, Froelich, Lutz, Sleegers, Kristel, Dobricic, Valerija, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie J B, Bos, Isabelle, Smit, August B, Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E, Bertram, Lars, Zetterberg, Henrik, Tijms, Betty M

“…Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer's disease (AD) and is considered to result from…”
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PROTEIN QUANTITATIVE TRAIT LOCI (PQTL) MAPPING OF THE CEREBROSPINAL FLUID PROTEOME by Reus, Lianne, Teunissen, Charlotte E., Gobom, Johan, Vos, Stephanie J.B., Blennow, Kaj, Zetterberg, Henrik, Bertram, Lars, Visser, Pieter Jelle, Tijms, Betty M.

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Post‐GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3 by Panyard, Daniel J., Reus, Lianne M., Ali, Muhammad, Liu, Jihua, Deming, Yuetiva K., Lu, Qiongshi, Kollmorgen, Gwendlyn, Carboni, Margherita, Wild, Norbert, Visser, Pieter J., Bertram, Lars, Zetterberg, Henrik, Blennow, Kaj, Gobom, Johan, Western, Dan, Sung, Yun Ju, Carlsson, Cynthia M., Johnson, Sterling C., Asthana, Sanjay, Cruchaga, Carlos, Tijms, Betty M., Engelman, Corinne D., Snyder, Michael P.

“…INTRODUCTION Recent genome‐wide association studies (GWAS) have reported a genetic association with Alzheimer's disease (AD) at the TNIP1/GPX3 locus, but the…”
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CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease by Delvenne, Aurore, Gobom, Johan, Schindler, Suzanne E., Kate, Mara ten, Reus, Lianne M., Dobricic, Valerija, Tijms, Betty M., Benzinger, Tammie L. S., Cruchaga, Carlos, Teunissen, Charlotte E., Ramakers, Inez, Martinez‐Lage, Pablo, Tainta, Mikel, Vandenberghe, Rik, Schaeverbeke, Jolien, Engelborghs, Sebastiaan, Roeck, Ellen De, Popp, Julius, Peyratout, Gwendoline, Tsolaki, Magda, Freund‐Levi, Yvonne, Lovestone, Simon, Streffer, Johannes, Barkhof, Frederik, Bertram, Lars, Blennow, Kaj, Zetterberg, Henrik, Visser, Pieter Jelle, Vos, Stephanie J. B.

“…INTRODUCTION We aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and…”
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Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer's disease biomarkers by Weiner, Sophia, Sauer, Mathias, Visser, Pieter Jelle, Tijms, Betty M, Vorontsov, Egor, Blennow, Kaj, Zetterberg, Henrik, Gobom, Johan

“…Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer's disease (AD). By employing tandem mass tag…”
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Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non‐Alzheimer's disease pathophysiology by Delvenne, Aurore, Gobom, Johan, Tijms, Betty, Bos, Isabelle, Reus, Lianne M., Dobricic, Valerija, Kate, Mara ten, Verhey, Frans, Ramakers, Inez, Scheltens, Philip, Teunissen, Charlotte E., Vandenberghe, Rik, Schaeverbeke, Jolien, Gabel, Silvy, Popp, Julius, Peyratout, Gwendoline, Martinez‐Lage, Pablo, Tainta, Mikel, Tsolaki, Magda, Freund‐Levi, Yvonne, Lovestone, Simon, Streffer, Johannes, Barkhof, Frederik, Bertram, Lars, Blennow, Kaj, Zetterberg, Henrik, Visser, Pieter Jelle, Vos, Stephanie J. B.

“…Background Suspected non‐Alzheimer's disease pathophysiology (SNAP) is a biomarker concept that encompasses individuals with neuronal injury but without…”
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Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology by Wolzak, Kimberly, Vermunt, Lisa, Campo, Marta del, Jorge‐Oliva, Marta, Ziel, Anna Maria, Li, Ka Wan, Smit, August B., Chen‐Ploktkin, Alice, Irwin, David J., Lemstra, Afina W., Pijnenburg, Yolande, Flier, Wiesje, Zetterberg, Henrik, Gobom, Johan, Blennow, Kaj, Visser, Pieter Jelle, Teunissen, Charlotte E., Tijms, Betty M., Scheper, Wiep

“…INTRODUCTION Cerebrospinal fluid (CSF) biomarkers for specific cellular disease processes are lacking for tauopathies. In this translational study we aimed to…”
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Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia by Sogorb-Esteve, Aitana, Nilsson, Johanna, Swift, Imogen J, Heller, Carolin, Bocchetta, Martina, Russell, Lucy L, Peakman, Georgia, Convery, Rhian S, van Swieten, John C, Seelaar, Harro, Borroni, Barbara, Galimberti, Daniela, Sanchez-Valle, Raquel, Laforce, Jr, Robert, Moreno, Fermin, Synofzik, Matthis, Graff, Caroline, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James B, Vandenberghe, Rik, Finger, Elizabeth, Tagliavini, Fabrizio, Santana, Isabel, Butler, Chris R, Ducharme, Simon, Gerhard, Alexander, Danek, Adrian, Levin, Johannes, Otto, Markus, Sorbi, Sandro, Le Ber, Isabelle, Pasquier, Florence, Gobom, Johan, Brinkmalm, Ann, Blennow, Kaj, Zetterberg, Henrik, Rohrer, Jonathan D

“…Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT…”
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