Search Results - "Gobeil, C."

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity by Gobeil, Sophie M-C, Janowska, Katarzyna, McDowell, Shana, Mansouri, Katayoun, Parks, Robert, Stalls, Victoria, Kopp, Megan F, Manne, Kartik, Li, Dapeng, Wiehe, Kevin, Saunders, Kevin O, Edwards, Robert J, Korber, Bette, Haynes, Barton F, Henderson, Rory, Acharya, Priyamvada

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with multiple spike mutations enable increased transmission and antibody resistance. We…”
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Controlling the SARS-CoV-2 spike glycoprotein conformation by Henderson, Rory, Edwards, Robert J., Mansouri, Katayoun, Janowska, Katarzyna, Stalls, Victoria, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Parks, Rob, Hsu, Allen L., Borgnia, Mario J., Haynes, Barton F., Acharya, Priyamvada

“…The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary immunogenic target for virus neutralization and the current focus…”
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D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction by Gobeil, Sophie M.-C., Janowska, Katarzyna, McDowell, Shana, Mansouri, Katayoun, Parks, Robert, Manne, Kartik, Stalls, Victoria, Kopp, Megan F., Henderson, Rory, Edwards, Robert J., Haynes, Barton F., Acharya, Priyamvada

“…The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of vaccine design efforts to end the coronavirus disease 2019…”
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cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike by Stalls, Victoria, Lindenberger, Jared, Gobeil, Sophie M.-C., Henderson, Rory, Parks, Rob, Barr, Maggie, Deyton, Margaret, Martin, Mitchell, Janowska, Katarzyna, Huang, Xiao, May, Aaron, Speakman, Micah, Beaudoin, Esther, Kraft, Bryan, Lu, Xiaozhi, Edwards, Robert J., Eaton, Amanda, Montefiori, David C., Williams, Wilton, Saunders, Kevin O., Wiehe, Kevin, Haynes, Barton F., Acharya, Priyamvada

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sub-lineage has gained in proportion relative to BA.1. Because spike (S) protein…”
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Structural diversity of the SARS-CoV-2 Omicron spike by Gobeil, Sophie M.-C., Henderson, Rory, Stalls, Victoria, Janowska, Katarzyna, Huang, Xiao, May, Aaron, Speakman, Micah, Beaudoin, Esther, Manne, Kartik, Li, Dapeng, Parks, Rob, Barr, Maggie, Deyton, Margaret, Martin, Mitchell, Mansouri, Katayoun, Edwards, Robert J., Eaton, Amanda, Montefiori, David C., Sempowski, Gregory D., Saunders, Kevin O., Wiehe, Kevin, Williams, Wilton, Korber, Bette, Haynes, Barton F., Acharya, Priyamvada

“…Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential…”
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents by Juvvadi, Praveen R., Fox, David, Bobay, Benjamin G., Hoy, Michael J., Gobeil, Sophie M. C., Venters, Ronald A., Chang, Zanetta, Lin, Jackie J., Averette, Anna Floyd, Cole, D. Christopher, Barrington, Blake C., Wheaton, Joshua D., Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D., Schumacher, Maria A., Heitman, Joseph, Steinbach, William J.

“…Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive…”
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DIGITAL TWIN AND 3D DOCUMENTATION OF A THEBAN TOMB AT DEIR AL-MEDINA (EGYPT) USING A MULTI-LENSES PHOTOGRAMMETRIC APPROACH by Mandelli, A., Gobeil, C., Greco, C., Rossi, C.

“…This paper describes the methodology employed in 2020 to perform the 3D survey of the Tomb TT214 at Deir al-Medina (Egypt). The aim of the archaeological…”
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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs by Gobeil, Sophie M-C, Bobay, Benjamin G, Juvvadi, Praveen R, Cole, D Christopher, Heitman, Joseph, Steinbach, William J, Venters, Ronald A, Spicer, Leonard D

“…Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically…”
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Canadian guidelines on the management of colorectal peritoneal metastases by Brind'Amour, A, Dubé, P, Tremblay, J F, Soucisse, M L, Mack, L, Bouchard-Fortier, A, McCart, J A, Govindarajan, A, Bischof, D, Haase, E, Giacomantonio, C, Hebbard, P, Younan, R, MacNeill, A, Boulanger-Gobeil, C, Sidéris, L

“…Modern management of colorectal cancer (crc) with peritoneal metastasis (pm) is based on a combination of cytoreductive surgery (crs), systemic chemotherapy,…”
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Natural rates of sediment containment of PAH, PCB and metal inventories in Sydney Harbour, Nova Scotia by Smith, J.N., Lee, K., Gobeil, C., Macdonald, R.W.

“…Analyses of metal and organic contaminants were carried out on 41 sediment cores, dated using 210Pb and 137Cs, from the heavily industrialized region of Sydney…”
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Thallium diagenesis in lacustrine sediments by Laforte, Lucie, Tessier, André, Gobeil, Charles, Carignan, Richard

“…Dated sediment cores and porewaters from two Canadian Shield lakes, located 40 km from Québec City (L. Tantaré) and 25 km downwind from an important smelter in…”
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Sources and chronology of atmospheric lead deposition to a Canadian Shield lake: Inferences from Pb isotopes and PAH profiles by Gallon, Céline, Tessier, André, Gobeil, Charles, Beaudin, Luc

“…The depth-distribution of lead and its stable isotope ratios were determined in a dated sediment core from a Canadian Shield lake receiving anthropogenic Pb…”
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Cold sensitivity of the SARS-CoV-2 spike ectodomain by Edwards, Robert J., Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H., Sprenz, Jordan, Williams, Wilton, Saunders, Kevin O., Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Munir Alam, S., Haynes, Barton F., Acharya, Priyamvada

“…The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its receptor binding domain in two conformations, the…”
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Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions by Clouthier, Christopher M, Morin, Sébastien, Gobeil, Sophie M C, Doucet, Nicolas, Blanchet, Jonathan, Nguyen, Elisabeth, Gagné, Stéphane M, Pelletier, Joelle N

“…Enzyme engineering has been facilitated by recombination of close homologues, followed by functional screening. In one such effort, chimeras of two class-A…”
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A sediment and organic carbon budget for the Canadian Beaufort Shelf by Macdonald, R.W., Solomon, S.M., Cranston, R.E., Welch, H.E., Yunker, M.B., Gobeil, C.

“…The Arctic Ocean accounts for 20% of the world's continental shelves. Because the Arctic is sensitive to global change, budgets of organic carbon for its…”
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Mercury Profiles in Sediments of the Arctic Ocean Basins by Gobeil, Charles, Macdonald, Robie W, Smith, John N

“…Total Hg distributions have been measured for seven sediment cores collected from the major basins of the Arctic Ocean during the Arctic Ocean Section in 1994…”
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Sediment redox tracers in Strait of Georgia sediments – Can they inform us of the loadings of organic carbon from municipal wastewater? by Macdonald, R.W., Johannessen, S.C., Gobeil, C., Wright, C., Burd, B., Roodselaar, A. van, Pedersen, T.F.

“…Organic carbon composition and redox element (Mn, Cd, U, Re, Mo, ΣS, AVS) distributions are examined in seven 210Pb-dated box cores collected from the Strait…”
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Recent change in organic carbon flux to Arctic Ocean deep basins: Evidence from acid volatile sulfide, manganese and rhenium discord in sediments by Gobeil, C., Sundby, B., Macdonald, R. W., Smith, J. N.

“…Evidence of recent large‐scale change in redox conditions in Arctic Ocean basin sediments is found in profiles of solid phase acid volatile sulfide (AVS), Mn,…”
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Atlantic Water Flow Pathways Revealed by Lead Contamination in Arctic Basin Sediments by Gobeil, Charles, Macdonald, Robie W., Smith, John N., Beaudin, Luc

“…Contaminant lead in sediments underlying boundary currents in the Arctic Ocean provides an image of current organization and stability during the past 50…”
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Dissolved aluminum in the upper St. Lawrence Estuary by TAKAYANAGI, Kazufumi, GOBEIL, Charles

“…The concentrations of dissolved aluminum (Al) in the upper St. Lawrence Estuary were determined during periods of high and intermediate river-discharge…”
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