Search Results - "Gobbi, Marco De"

Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells by Calabrese, Chiara, Panuzzo, Cristina, Stanga, Serena, Andreani, Giacomo, Ravera, Silvia, Maglione, Alessandro, Pironi, Lucrezia, Petiti, Jessica, Shahzad Ali, Muhammad Shahzad, Scaravaglio, Patrizia, Napoli, Francesca, Fava, Carmen, De Gobbi, Marco De, Frassoni, Francesco, Saglio, Giuseppe, Bracco, Enrico, Pergolizzi, Barbara, Cilloni, Daniela

“…I is crucial to satisfy several mitochondrial functions including energy metabolism and oxidative phosphorylation. Patients affected by Myelodysplastic…”
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Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression by Vernimmen, Douglas, Gobbi, Marco De, Sloane-Stanley, Jacqueline A, Wood, William G, Higgs, Douglas R

“…To understand how mammalian genes are regulated from their natural chromosomal environment, we have analysed the molecular events occurring throughout a 150 kb…”
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Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment by Hughes, Jim R, Roberts, Nigel, McGowan, Simon, Hay, Deborah, Giannoulatou, Eleni, Lynch, Magnus, De Gobbi, Marco, Taylor, Stephen, Gibbons, Richard, Higgs, Douglas R

“…Douglas Higgs and colleagues report a high-throughput approach, called Capture-C, to analyze interactions between cis regulatory elements. Using Capture-C, the…”
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Generation of bivalent chromatin domains during cell fate decisions by De Gobbi, Marco, Garrick, David, Lynch, Magnus, Vernimmen, Douglas, Hughes, Jim R, Goardon, Nicolas, Luc, Sidinh, Lower, Karen M, Sloane-Stanley, Jacqueline A, Pina, Cristina, Soneji, Shamit, Renella, Raffaele, Enver, Tariq, Taylor, Stephen, Jacobsen, Sten Eirik W, Vyas, Paresh, Gibbons, Richard J, Higgs, Douglas R

“…In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for…”
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Bcl‐xL represents a therapeutic target in Philadelphia negative myeloproliferative neoplasms by Petiti, Jessica, Lo Iacono, Marco, Rosso, Valentina, Andreani, Giacomo, Jovanovski, Aleksandar, Podestà, Marina, Lame, Dorela, Gobbi, Marco De, Fava, Carmen, Saglio, Giuseppe, Frassoni, Francesco, Cilloni, Daniela

“…Myeloproliferative neoplasms are divided into essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). Although ruxolitinib was…”
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Shedding Light on the Pathogenesis of Splanchnic Vein Thrombosis by Camerlo, Sofia, Ligato, Jacopo, Rosati, Giorgio, Carrà, Giovanna, Russo, Isabella, De Gobbi, Marco, Morotti, Alessandro

“…Splanchnic vein thrombosis is a rare but potentially life-threatening manifestation of venous thromboembolism, with challenging implications both at the…”
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An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment by Lynch, Magnus D, Smith, Andrew J H, De Gobbi, Marco, Flenley, Maria, Hughes, Jim R, Vernimmen, Douglas, Ayyub, Helena, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Sutherland, Linda, Meek, Stephen, Burdon, Tom, Gibbons, Richard J, Garrick, David, Higgs, Douglas R

“…The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human…”
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Intragenic Enhancers Act as Alternative Promoters by Kowalczyk, Monika S., Hughes, Jim R., Garrick, David, Lynch, Magnus D., Sharpe, Jacqueline A., Sloane-Stanley, Jacqueline A., McGowan, Simon J., De Gobbi, Marco, Hosseini, Mona, Vernimmen, Douglas, Brown, Jill M., Gray, Nicola E., Collavin, Licio, Gibbons, Richard J., Flint, Jonathan, Taylor, Stephen, Buckle, Veronica J., Milne, Thomas A., Wood, William G., Higgs, Douglas R.

“…A substantial amount of organismal complexity is thought to be encoded by enhancers which specify the location, timing, and levels of gene expression. In…”
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Autologous Hematopoietic Stem Cell Transplantation (AHSCT): Standard of Care for Relapsing–Remitting Multiple Sclerosis Patients by Bertolotto, Antonio, Martire, Serena, Mirabile, Luca, Capobianco, Marco, De Gobbi, Marco, Cilloni, Daniela

“…Autologous hematopoietic stem cell transplantation (AHSCT) has been used in the treatment of highly active multiple sclerosis (MS) for over two decades. It has…”
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Acute Promyelocytic Leukemia and Brugada Syndrome: A Report on the Safety of Arsenic Trioxide/All-Trans-Retinoic Acid Therapy by Rosati, Giorgio, Camerlo, Sofia, Dalmazzo, Matteo, Padrini, Melissa, Busana, Tiziano Tommaso, De Gobbi, Marco, Fornari, Alessandro, Morotti, Alessandro

“…Acute promyelocytic leukemia (APL) is a rare and aggressive form of acute myeloid leukemia (AML). Instead of cytotoxic chemotherapy, a combination of…”
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Polycomb eviction as a new distant enhancer function by Vernimmen, Douglas, Lynch, Magnus D, De Gobbi, Marco, Garrick, David, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Smith, Andrew J H, Higgs, Douglas R

“…Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly understood…”
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Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter by De Gobbi, Marco, Viprakasit, Vip, Hughes, Jim R, Fisher, Chris, Buckle, Veronica J, Ayyub, Helena, Gibbons, Richard J, Vernimmen, Douglas, Yoshinaga, Yuko, de Jong, Pieter, Cheng, Jan-Fang, Rubin, Edward M, Wood, William G, Bowden, Don, Higgs, Douglas R

“…We describe a pathogenetic mechanism underlying a variant form of the inherited blood disorder α thalassemia. Association studies of affected individuals from…”
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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 by Gasparini, Paolo, Camaschella, Clara, Roetto, Antonella, Calì, Angelita, De Gobbi, Marco, Garozzo, Giovanni, Carella, Massimo, Majorano, Nunzia, Totaro, Angela

“…Haemochromatosis is a common recessive disorder characterized by progressive iron overload, which may lead to severe clinical complications. Most patients are…”
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Analysis of Mesenchymal Stromal Cell Engraftment After Allogeneic HSCT in Pediatric Patients: A Large Multicenter Study by Castello, Laura M, Leone, Marco, Adamini, Aloe, Castiglia, Sara, Mareschi, Katia, Ferrero, Ivana, Marco, De Gobbi, Carnevale-Schianca, Fabrizio, Fagioli, Franca, Berger, Massimo

“…The mesenchymal stem cell (MSC) role after allogeneic hematopoietic stem cell transplantation (HSCT) is still a matter of debate; in particular, MSC…”
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Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition by Lower, Karen M, Hughes, Jim R, De Gobbi, Marco, Henderson, Shirley, Viprakasit, Vip, Fisher, Chris, Goriely, Anne, Ayyub, Helena, Sloane-Stanley, Jackie, Vernimmen, Douglas, Langford, Cordelia, Garrick, David, Gibbons, Richard J, Higgs, Douglas R

“…It is well established that all of the cis-acting sequences required for fully regulated human α-globin expression are contained within a region of [almost…”
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Rhino-Orbital-Cerebral Mucormycosis after Allogeneic Hematopoietic Stem Cell Transplantation and Isavuconazole Therapeutic Drug Monitoring during Intestinal Graft versus Host Disease by Andreani, Giacomo, Fadda, Gianluca, Gned, Dario, Dragani, Matteo, Cavallo, Giovanni, Monticone, Valentina, Morotti, Alessandro, De Gobbi, Marco, Guerrasio, Angelo, D'Avolio, Antonio, Cilloni, Daniela

“…  A  diagnosis of rhino-orbital-cerebral mucormycosis was made in a 59-year-old man with a secondary acute myeloid leukemia a few days after hematopoietic stem…”
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P372: CMV REACTIVATIONS/INFECTIONS IN PH+ ALL PATIENTS TREATED WITH DASATINIB WITH OR WITHOUT BLINATUMOMAB. A RETROSPECTIVE MULTICENTER CAMPUS ALL STUDY by Annunziata, Mario, Lunghi, Monia, Giglio, Fabio, Leoncin, Matteo, Dargenio, Michelina, Bonifacio, Massimiliano, De Gobbi, Marco, Mazzone, Carla, Agrippino, Roberta, Lazzarotto, Davide, Roncoroni, Elisa, Defina, Marzia, Fracchiolla, Nicola, Guolo, Fabio, Ilaria Del Principe, Maria, Scappini, Barbara, Mulè, Antonino, Ciccone, Maria, Pasciolla, Crescenza, Ferrara, Felicetto, Pizzolo, Giovanni, Foà, Robin, Chiaretti, Sabina

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P1539: INFECTION‐RELATED MORTALITY CLINICAL‐BIOLOGICAL SCORING SYSTEM (IRM‐SCORE) AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: A VALIDATION STUDY IN GITMO CENTRES by Clerici, Daniela, Liberatore, Carmine, Rancoita, Paola Maria, Dellacasa, Chiara Maria, Patriarca, Francesca, Corradini, Paolo, Saccardi, Riccardo, Carella, Angelo Michele, Santarone, Stella, Musso, Maurizio, Iori, Anna Paola, Chiusolo, Patrizia, Onida, Francesco, Mordini, Nicola, Gobbi, Marco De, Galieni, Piero, Luppi, Mario, Aglietta, Massimo, Vallisa, Daniele, Storti, Gabriella, Facchini, Luca, Peccatori, Jacopo, Ruggeri, Annalisa, Greco, Raffaella, Corti, Consuelo, Bonifazi, Francesca, Ciceri, Fabio

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HSCT with Mismatched Unrelated Donors (MMUD): A Comparison of Different Platforms for GvHD Prophylaxis by Berger, Massimo, Barone, Marta, Carnevale-Schianca, Fabrizio, De Gobbi, Marco, Nicoli, Paolo, Caravelli, Daniela, Cilloni, Daniela, Paruzzo, Luca, Spadea, Manuela, Mareschi, Katia, Aglietta, Massimo, Fagioli, Franca

“…HSCT from an unrelated HLA-mismatched donor (MMUD) is one of the alternatives where an HLA-matched donor is not found. The aim of this study was to compare…”
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P686: REAL‐WORLD EFFICACY PROFILE OF ASCIMINIB IN AN ITALIAN, MULTI‐RESISTANT CHRONIC‐PHASE CHRONIC MYELOID LEUKEMIA (CP‐CML) PATIENT POPULATION by Breccia, Massimo, Russo Rossi, Antonella, Giai, Valentina, Martino, Bruno, Fava, Carmen, Annunziata, Mario, Abruzzese, Elisabetta, Binotto, Gianni, Baratè, Claudia, Pio Nardozza, Aurelio, Misto, Alessandra, Coco, Paola, Calafiore, Valeria, Cristina Carraro, Maria, Cattina, Federica, Cavazzini, Francesco, Teresa Corsetti, Maria, Crucitti, Lara, Crugnola, Monica, Ditonno, Paolo, DI Veroli, Ambra, Ermacora, Anna, Ferrara, Felicetto, Genua, Angelo, Gozzini, Antonella, Impera, Stefana, Iurlo, Alessandra, Levato, Luciano, Luciano, Luigiana, Cristina Miggiano, Maria, De Gobbi, Marco, Santoro, Marco, Scappini, Barbara, Rita Scortechini, Anna, Patriarca, Andrea, Rosati, Serena, Russo, Sabina, Sancetta, Rosaria, Sanpaolo, Grazia, Maria Santeramo, Teresa, Sibilla, Silvia, Sorà, Federica, Sportoletti, Paolo, Stagno, Fabio, Trabacchi, Elena, Castagnetti, Fausto

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