Search Results - "Goay, Stephanie Shee Min"

Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response by Goggi, Julian L, Khanapur, Shivashankar, Ramasamy, Boominathan, Hartimath, Siddesh V, Rong, Tang Jun, Cheng, Peter, Tan, Yun Xuan, Yeo, Xin Yi, Jung, Sangyong, Goay, Stephanie Shee Min, Ong, Seow Theng, Hwang, You Yi, Chandy, K George, Robins, Edward G

“…Immune checkpoint inhibitors have shown great promise, emerging as a new pillar of treatment for cancer; however, only a relatively small proportion of…”
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Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug by Tyagi, Anu, Ahmed, Tofayel, Jian, Shi, Bajaj, Saumya, Ong, Seow Theng, Goay, Stephanie Shee Min, Zhao, Yue, Vorobyov, Igor, Tian, Changlin, Chandy, K George, Bhushan, Shashi

“…We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called…”
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Repercussions of high extracellular K +on T-cell antitumor responses by WONG, BRANDON HAN SIANG, Ong, Seow Theng, Goay, Stephanie Shee Min, Ho, Ying Swan, Chen, Shuwen, Bi, Xuezhi, Webster, Richard D., Shelat, Vishalkumar G., Verma, Navin Kumar

“…Abstract Tumours create an immunosuppressive microenvironment that limits the antitumor function of infiltrating T-cells. Dying/necrotic tumor cells extrude…”
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A new kCa3.1 channel activator SKA-346 boosts T-cell antitumor response in the immune suppressive microenvironment by Verma, Navin K., Siang Wong, Brandon Han, Theng Ong, Seow, Min Goay, Stephanie Shee, Swan Ho, Ying, Chen, Shuwen, Bi, Xuezhi, Shim, Heesung, Wulff, Heike, Chandy, K. George

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Augmenting the activity of calcium-activated potassium channel KCa3.1 revitalizes T-cell function in the immunosuppressive tumor microenvironment by Verma, Navin K., Siang Wong, Brandon Han, Theng Ong, Seow, Min Goay, Stephanie Shee, Swan Ho, Ying, Chen, Shuwen, Bi, Xuezhi, Shim, Heesung, Wulff, Heike, Webster, Richard D., Shelat, Vishalkumar G., Chandy, K. George

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Augmenting the activity of calcium-activated potassium channel K Ca 3.1 revitalizes T-cell function in the immunosuppressive tumor microenvironment by Verma, Navin K, Siang Wong, Brandon Han, Theng Ong, Seow, Min Goay, Stephanie Shee, Swan Ho, Ying, Chen, Shuwen, Bi, Xuezhi, Shim, Heesung, Wulff, Heike, Webster, Richard D, Shelat, Vishalkumar G, Chandy, K George

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