Romanian Registry of Hypertrophic Cardiomyopathy - overview of general characteristics and therapeutic choices at a national level

Hypertrophic cardiomyopathy (HCM) is a disease with increased left ventricular (LV) wall thickness not solely explained by abnormal loading conditions, with great heterogeneity regarding clinical expression and prognosis. The aim of the present study was to collect data on HCM patients from differen...

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Published in:	Revue roumaine de médecine interne (1990) Vol. 56; no. 3; pp. 203 - 209
Main Authors:	Ionilă, Paula, Jurcuţ, Ruxandra, Ferariu, Nicoleta, Roşca, Monica, Chivulescu, Monica, Mursă, Adriana, Militaru, Sebastian, Ionescu, Alin A, Căldăraru, Cristina, Fruntelată, Ana G, Goanţă, Silvia F, Crişan, Simina, Ionac, Adina, Avram, Ana-Maria, Frigy, Attila, Sascău, Radu, Arsenescu-Georgescu, Cătălina, Coman, Ioan M, Popescu, Bogdan A, Ginghină, Carmen, Apetrei, Eduard
Format:	Journal Article
Language:	English
Published:	Germany Sciendo 01-09-2018
Subjects:	arrhythmia echocardiography hypertrophic cardiomyopathy registry sudden death Echocardiography Registry Arrhythmia Sudden death Hypertrophic Cardiomyopathy
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Summary:	Hypertrophic cardiomyopathy (HCM) is a disease with increased left ventricular (LV) wall thickness not solely explained by abnormal loading conditions, with great heterogeneity regarding clinical expression and prognosis. The aim of the present study was to collect data on HCM patients from different centres across the country, in order to assess the general characteristics and therapeutic choices in this population. Between December 2014 and April 2017, 210 patients from 11 Romanian Cardiology centres were enrolled in the National Registry of HCM. All patients had to fulfil the diagnosis criteria for HCM according to the European Society of Cardiology guidelines. Clinical, electrocardiographic, imaging and therapeutic characteristics were included in a predesigned online file. Median age at enrolment was 55 ± 15 years with male predominance (60%). 43.6% of the patients had obstructive HCM, 50% non-obstructive HCM, while 6.4% had an apical pattern. Maximal wall thickness was 20.3 ± 4.8 mm (limits 15-37 mm) while LV ejection fraction was 60 ± 8%. Heart failure symptoms dominated the clinical picture, mainly NYHA functional class II (51.4%). Most frequent arrhythmias were atrial fibrillation (28.1%) and non-sustained ventricular tachycardia (19.9%). Mean sudden cardiac death risk score (SCD-RS) was 3.0 ± 2.3%, with 10.4% of the patients with high risk of SCD. However, only 5.7% received an ICD. Patients were mainly treated with beta-blockers (72.9%), diuretics (28.1%) and oral anticoagulants (28.6%). Invasive treatment of LVOT obstruction was performed in a small number of patients: 22 received myomectomy and 13 septal ablation. Cardiac magnetic resonance was reported in only 14 patients (6.6%). The Romanian registry of HCM illustrates patient characteristics at a national level as well as the gaps in management which need improvement - accessibility to high-end diagnostic tests and invasive methods of treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1220-4749 2501-062X
DOI:	10.2478/rjim-2018-0012