Search Results - "Götz, Mario E."

Myristicin and Elemicin: Potentially Toxic Alkenylbenzenes in Food by Götz, Mario E, Sachse, Benjamin, Schäfer, Bernd, Eisenreich, Andreas

“…Alkenylbenzenes represent a group of naturally occurring substances that are synthesized as secondary metabolites in various plants, including nutmeg and…”
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Alkenylbenzenes in Foods: Aspects Impeding the Evaluation of Adverse Health Effects by Eisenreich, Andreas, Götz, Mario E., Sachse, Benjamin, Monien, Bernhard H., Herrmann, Kristin, Schäfer, Bernd

“…Alkenylbenzenes are naturally occurring secondary plant metabolites, primarily present in different herbs and spices, such as basil or fennel seeds. Thus,…”
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The Relevance of Iron in the Pathogenesis of Parkinson's Disease by GÖTZ, MARIO E., DOUBLE, KAY, GERLACH, MANFRED, YOUDIM, MOUSSA B. H., RIEDERERE, PETER

“…: Investigations that revealed increased levels of iron in postmortem brains from patients with Parkinson's disease (PD) as compared to those from individuals…”
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Occurrence of Alkenylbenzenes in Plants: Flavours and Possibly Toxic Plant Metabolites by Götz, Mario E, Eisenreich, Andreas, Frenzel, Janine, Sachse, Benjamin, Schäfer, Bernd

“…Alkenylbenzenes are naturally occurring secondary plant metabolites. While some of them are proven genotoxic carcinogens, other derivatives need further…”
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Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease by Völkel, Wolfgang, Sicilia, Tina, Pähler, Axel, Gsell, W., Tatschner, Thomas, Jellinger, Kurt, Leblhuber, Friedrich, Riederer, Peter, Lutz, Werner K., Götz, Mario E.

“…In the last decade an important role for the progression of neuronal cell death in Alzheimer's disease (AD) has been ascribed to oxidative stress…”
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3-MCPD as contaminant in processed foods: State of knowledge and remaining challenges by Eisenreich, Andreas, Monien, Bernhard H., Götz, Mario E., Buhrke, Thorsten, Oberemm, Axel, Schultrich, Katharina, Abraham, Klaus, Braeuning, Albert, Schäfer, Bernd

“…•3-Chloro-1,2-propanediol (3-MCPD) is present as contaminants in different foods.•3-MCPD is a non-genotoxic compound exhibiting secondary carcinogenic…”
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Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data by Menz, Jakob, Götz, Mario E., Gündel, Ulrike, Gürtler, Rainer, Herrmann, Kristin, Hessel-Pras, Stefanie, Kneuer, Carsten, Kolrep, Franziska, Nitzsche, Dana, Pabel, Ulrike, Sachse, Benjamin, Schmeisser, Sebastian, Schumacher, David M., Schwerdtle, Tanja, Tralau, Tewes, Zellmer, Sebastian, Schäfer, Bernd

“…Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. For more than a decade,…”
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Nrf2 Induces Interleukin-6 (IL-6) Expression via an Antioxidant Response Element within the IL-6 Promoter by Wruck, Christoph Jan, Streetz, Konrad, Pavic, Goran, Götz, Mario E., Tohidnezhad, Mersedeh, Brandenburg, Lars-Ove, Varoga, Deike, Eickelberg, Oliver, Herdegen, Thomas, Trautwein, Christian, Cha, Kaimin, Kan, Yuet Wai, Pufe, Thomas

“…IL-6 gene expression is controlled by a promoter region containing multiple regulatory elements such as NF-κB, NF-IL6, CRE, GRE, and TRE. In this study, we…”
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Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation by Renner, André, Sagstetter, Martina R, Harms, Harry, Lange, Volkmar, Götz, Mario E, Elert, Olaf

“…Free radicals formed during ischemia and reperfusion can lead to lipid peroxidation (LPO) and the formation of 4-hydroxy-2-nonenal (4-HNE), one of the most…”
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Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation by Wruck, Christoph J, Götz, Mario E, Herdegen, Thomas, Varoga, Deike, Brandenburg, Lars-Ove, Pufe, Thomas

“…One hallmark of Alzheimer's disease is the accumulation of amyloid beta-peptide (AP), which can initiate a cascade of oxidative events that may result in…”
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Risk assessment of nanomaterials in cosmetics: a European union perspective by Henkler, Frank, Tralau, Tewes, Tentschert, Jutta, Kneuer, Carsten, Haase, Andrea, Platzek, Thomas, Luch, Andreas, Götz, Mario E.

“…In Europe, the data requirements for the hazard and exposure characterisation of chemicals are defined according to the REACH regulation and its guidance on…”
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Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics by Yamamoto, Megumi, Pohli, Sabine, Durany, Nuria, Ozawa, Hiroki, Saito, Toshikazu, Boissl, Karl W., Zöchling, Robert, Riederer, Peter, Böning, Jobst, Götz, Mario E.

“…— We examined amounts of cAMP response element binding protein (CREB) and its phosphorylated form in post-mortem frontal and temporal cortices and cerebella…”
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A knowledge-based search engine to navigate the information thicket of nanotoxicology by Sauer, Ursula G., Kneuer, Carsten, Tentschert, Jutta, Wächter, Thomas, Schroeder, Michael, Butzke, Daniel, Luch, Andreas, Liebsch, Manfred, Grune, Barbara, Götz, Mario E.

“…The risk assessment of nano-sized materials (NM) currently suffers from great uncertainties regarding their putative toxicity for humans and the environment…”
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Heterotopic rat heart transplantation: severe loss of glutathione in 8-hour ischemic hearts by Renner, André, Sagstetter, Martina R, Götz, Mario E, Lange, Volkmar, Bengel, Dominik, Harms, Harry, Riederer, Peter, Elert, Olaf

“…Tissue damage caused by reactive oxygen species (ROS) formed during ischemia/reperfusion seems to be an important risk factor in the failure of transplanted…”
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Increased levels of calcium-sensitive adenylyl cyclase subtypes in the limbic system of alcoholics: evidence for a specific role of cAMP signaling in the human addictive brain by Yamamoto, Megumi, Pohli, Sabine, Durany, Nuria, Ozawa, Hiroki, Saito, Toshikazu, Boissl, Karl W., Zöchling, Robert, Riederer, Peter, Böning, Jobst, Götz, Mario E.

“…We examined the amounts of several adenylyl cyclase (AC) isoforms and of cAMP-response element binding protein (CREB) in alcoholic and control brains…”
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Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection by Koutsilieri, Eleni, Scheller, Carsten, Sopper, Sieghart, Götz, Mario E, Gerlach, Manfred, Meulen, Volker ter, Riederer, Peter

“…Human immunodeficiency virus (HIV) infection is associated with a progressive dementia, in addition to motor and behavioural deficits. Cognitive deterioration…”
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Monoamine metabolite levels in CSF of SIV-infected rhesus monkeys (Macaca mulatta) by Koutsilieri, Eleni, Götz, Mario E, Sopper, Sieghart, Stahl-Hennig, Christiane, Czub, Markus, ter Meulen, Volker, Riederer, Peter

“…INCREASING evidence suggests the involvement of the basal ganglia in HIV-1-infected patients. We used SIV-macaques, an animal model of HIV-1 infection, to…”
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Regulation of glutathione and cell toxicity following exposure to neurotropic substances and human immunodeficiency virus-1 in vitro by Koutsilieri, E, Götz, M E, Sopper, S, Sauer, U, Demuth, M, ter Meulen, V, Riederer, P

“…The aim of the present study was to assess the toxic potential of drugs of abuse and other neuropharmacological agents in the pathogenesis of AIDS dementia…”
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Oxidative stress: free radical production in neural degeneration by Götz, M E, Künig, G, Riederer, P, Youdim, M B

“…It is not yet established whether oxidative stress is a major cause of cell death or simply a consequence of an unknown pathogenetic factor. Concerning chronic…”
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Advances in neuroprotection research for neurodegenerative diseases by Götz, Mario E, Riederer, Peter

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