Search Results - "Gómara, María J"

Implications of Post-Translational Modifications in Autoimmunity with Emphasis on Citrullination, Homocitrullination and Acetylation for the Pathogenesis, Diagnosis and Prognosis of Rheumatoid Arthritis by Haro, Isabel, Sanmartí, Raimon, Gómara, María J

“…Post-translational modifications (PTMs) influence cellular processes and consequently, their dysregulation is related to the etiologies of numerous diseases…”
Get full text

Peptides Bearing Multiple Post-Translational Modifications as Antigenic Targets for Severe Rheumatoid Arthritis Patients by García-Moreno, Cristina, Gómara, María J, Castellanos-Moreira, Raúl, Sanmartí, Raimon, Haro, Isabel

“…Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies that are of paramount importance for the diagnosis and prognosis of the disease…”
Get full text

Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel by Galindo-Camacho, Ruth M., Haro, Isabel, Gómara, María J., Espina, Marta, Fonseca, Joel, Martins-Gomes, Carlos, Camins, Antoni, Silva, Amélia M., García, María L., Souto, Eliana B.

“…[Display omitted] Licochalcone-A (Lico-A) PLGA NPs functionalized with cell penetrating peptides B6 and Tet-1 are proposed for the treatment of ocular…”
Get full text

Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression by Rodriguez-Martinez, Lorena, García-Moreno, Cristina, Perez-Pampin, Eva, Gómara, María J., Sarmiento-Monroy, Juan C., Lopez-Golán, Yolanda, Gómez-Puerta, José A., Mera-Varela, Antonio, Conde, Carmen, Sanmartí, Raimon, Haro, Isabel, González, Antonio

“…Background Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are…”
Get full text

Conjugation of cell-penetrating peptides with poly(lactic-co-glycolic acid)-polyethylene glycol nanoparticles improves ocular drug delivery by Vasconcelos, Aimee, Vega, Estefania, Pérez, Yolanda, Gómara, María J, García, María Luisa, Haro, Isabel

“…In this work, a peptide for ocular delivery (POD) and human immunodeficiency virus transactivator were conjugated with biodegradable poly(lactic-co-glycolic…”
Get full text

Design, Characterization, and Biopharmaceutical Behavior of Nanoparticles Loaded with an HIV‑1 Fusion Inhibitor Peptide by Ariza-Sáenz, Martha, Espina, Marta, Calpena, Ana, Gómara, María J, Pérez-Pomeda, Ignacio, Haro, Isabel, García, María Luisa

“…New therapeutic alternatives to fight against the spread of HIV-1 are based on peptides designed to inhibit the early steps of HIV-1 fusion in target cells…”
Get full text

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide by Schiroli, Davide, Gómara, María J., Maurizi, Eleonora, Atkinson, Sarah D., Mairs, Laura, Christie, Kathleen A., Cobice, Diego F., McCrudden, Cian M., Nesbit, M. Andrew, Haro, Isabel, Moore, Tara

“…Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA)…”
Get full text

Citrullinated peptides in the diagnosis of rheumatoid arthritis by Gómara, María J, Haro, Isabel

“…Antibodies directed against citrullinated proteins and peptides (ACPAs) are the most specific serological markers available for diagnosing rheumatoid arthritis…”
Get more information

Effect of Synthetic Peptides Belonging to E2 Envelope Protein of GB Virus C on Human Immunodeficiency Virus Type 1 Infection by Herrera, Elena, Tenckhoff, Solveig, Gómara, María J, Galatola, Ramona, Bleda, María J, Gil, Cristina, Ercilla, Guadalupe, Gatell, José M, Tillmann, Hans L, Haro, Isabel

“…The use of synthetic peptides as HIV-1 inhibitors has been subject to research over recent years. Although the initial therapeutic attempts focused on…”
Get full text

Comparative study of the diagnostic and prognostic value of antibodies against chimeric citrullinated synthetic peptides and CCP3/CCP3.1 assays by Gómara, María J, Rodríguez, Javier, Bleda, María J, Salvador, Juan P, Sanmartí, Raimon, Haro, Isabel

“…The objective of the study was to compare the diagnostic yield of home-made ELISA tests based on synthetic chimeric fibrin/filaggrin citrullinated peptides…”
Get more information

Neutrophilic Activity Biomarkers (Plasma Neutrophil Extracellular Traps and Calprotectin) in Established Patients with Rheumatoid Arthritis Receiving Biological or JAK Inhibitors: A Clinical and Ultrasonographic Study by Frade-Sosa, Beatriz, Ponce, Andrés, Ruiz-Ortiz, Estíbaliz, De Moner, Noemí, Gómara, María J., Azuaga, Ana Belén, Sarmiento-Monroy, Juan C., Morlà, Rosa, Ruiz-Esquide, Virginia, Macías, Laura, Sapena, Nuria, Tobalina, Lola, Ramirez, Julio, Cañete, Juan D., Yague, Jordi, Auge, Josep M., Gomez-Puerta, José A., Viñas, Odette, Haro, Isabel, Sanmarti, Raimon

“…Introduction This study assesses the accuracy of neutrophil activation markers, including neutrophil extracellular traps (NETs) and calprotectin, as biomarkers…”
Get full text

The Use of Chimeric Vimentin Citrullinated Peptides for the Diagnosis of Rheumatoid Arthritis by Malakoutikhah, Morteza, Gómara, María J, Gómez-Puerta, José A, Sanmartí, Raimon, Haro, Isabel

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and, in many cases, destruction of the joints. To prevent progressive and…”
Get full text

A cyclic GB virus C derived peptide with anti-HIV-1 activity targets the fusion peptide of HIV-1 by Galatola, Ramona, Vasconcelos, Aimee, Pérez, Yolanda, Cruz, Antonio, Pujol, Montserrat, Alsina, María A., Gómara, María J., Haro, Isabel

“…The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially…”
Get full text

HIV-1 inhibiting capacity of novel forms of presentation of GB virus C peptide domains is enhanced by coordination to gold compounds by Gómara, María J, Galatola, Ramona, Gutiérrez, Alejandro, Gimeno, María C, Gatell, José M, Sánchez-Merino, Víctor, Yuste, Eloísa, Haro, Isabel

“…Following the report of beneficial effects of co-infection by GB virus C (GBV-C) for HIV-infected patients, we have studied synthetic GBV-C peptides and their…”
Get more information

Antibodies to Citrullinated Human Fibrinogen Synthetic Peptides in Diagnosing Rheumatoid Arthritis by Pérez, María L, Gómara, María J, Ercilla, Guadalupe, Sanmartí, Raimon, Haro, Isabel

“…Since aggressive therapy given early in the rheumatoid arthritis (RA) disease course has the greatest therapeutic potential, early diagnostic tests with both…”
Get full text

Structural and Functional Roles of HIV-1 gp41 Pretransmembrane Sequence Segmentation by Sáez-Cirión, Asier, Arrondo, José L.R., Gómara, María J., Lorizate, Maier, Iloro, Ibón, Melikyan, Grigory, Nieva, José L.

“…The membrane-proximal segment connecting the helical core with the transmembrane anchor of human immunodeficiency virus type 1 gp41 is accessible to broadly…”
Get full text

Peptide Amphiphilic-Based Supramolecular Structures with Anti-HIV‑1 Activity by Gómara, Maria J, Pons, Ramon, Herrera, Carolina, Ziprin, Paul, Haro, Isabel

“…In a previous work, we defined a novel HIV-1 fusion inhibitor peptide (E1P47) with a broad spectrum of activity against viruses from different clades,…”
Get full text

Antibodies against β-fibrin synthetic peptides: A study of their association with the immunogenetic background and disease course of rheumatoid arthritis patients by Haro, Isabel, Gómara, María J., Pérez, María L., Viñas, Odette, Ercilla, Guadalupe, Gómez-Puerta, José A., Sanmartí, Raimon

“…Preliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic…”
Get full text

Synthetic peptides derived from an N-terminal domain of the E2 protein of GB virus C in the study of GBV-C/HIV-1 co-infection by Fernández, Leticia, Chan, Weng C., Egido, Meritxell, Gómara, María J., Haro, Isabel

“…Synthetic peptides derived from GB virus C (GBV‐C) have previously been studied in our group for the development of new systems capable of diagnosing diseases…”
Get full text

Membrane-transferring Sequences of the HIV-1 Gp41 Ectodomain Assemble into an Immunogenic Complex by Lorizate, Maier, Gómara, María J., de la Torre, Beatriz G., Andreu, David, Nieva, José L.

“…The membrane-proximal stem region of gp41 has been postulated to host the two conserved membrane-transferring domains that promote HIV-1 fusion: the…”
Get full text