Search Results - "Gołębiowski, Filip"
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Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
Published in Pharmaceuticals (Basel, Switzerland) (21-07-2021)“…TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight…”
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Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair
Published in Molecular cell (17-09-2015)“…Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision repair (NER). DNA lesions are initially detected by NER factors…”
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Lesion recognition by XPC, TFIIH and XPA in DNA excision repair
Published in Nature (London) (04-05-2023)“…Nucleotide excision repair removes DNA lesions caused by ultraviolet light, cisplatin-like compounds and bulky adducts 1 . After initial recognition by XPC in…”
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Application of PCR-HRM method for microsatellite polymorphism genotyping in the LDHA gene of pigeons (Columba livia)
Published in PloS one (19-08-2021)“…High-resolution melting (HRM) is a post-PCR method that allows to discriminate genotypes based on fluorescence changes during the melting phase. HRM is used to…”
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An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Published in Nature (London) (23-09-2021)“…Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients 1 . Both the…”
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An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity
Published in Proceedings of the National Academy of Sciences - PNAS (27-08-2019)“…Dynamic small ubiquitin-like modifier (SUMO) linkages to diverse cellular protein groups are critical to orchestrate resolution of stresses such as genome…”
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SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
Published in Genes & development (01-06-2012)“…Here we demonstrate that RNF4, a highly conserved small ubiquitin-like modifier (SUMO)-targeted ubiquitin E3 ligase, plays a critical role in the response of…”
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Durability and Corrosion Resistance Test of Adhesive Joints Using Two Adherence Promoters for the Connection of Aerospace Aluminum Alloys
Published in Materials (07-12-2022)“…This article presents the technology of making an adhesive joint using two primers: Corrosion Inhibiting Primer BR127 (previously used, containing chromium…”
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Global Reprogramming of Host SUMOylation during Influenza Virus Infection
Published in Cell reports (Cambridge) (17-11-2015)“…Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damage, and DNA virus infection. Here,…”
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An investigation of the affinities, specificity and kinetics involved in the interaction between the Yin Yang 1 transcription factor and DNA
Published in The FEBS journal (01-09-2012)“…Human transcription factor Yin Yang 1 (YY1) is a four zinc‐finger protein that regulates a large number of genes with various biological functions in processes…”
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Efficient overexpression and purification of active full-length human transcription factor Yin Yang 1 in Escherichia coli
Published in Protein expression and purification (01-06-2011)“…The Yin Yang 1 protein is a zinc finger transcription factor involved in the regulation of diverse cellular processes through DNA and protein–protein…”
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System-wide changes to SUMO modifications in response to heat shock
Published in Science signaling (26-05-2009)“…Covalent conjugation of the small ubiquitin-like modifier (SUMO) proteins to target proteins regulates many important eukaryotic cellular mechanisms. Although…”
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Lesion recognition by XPC, TFIIH and XPA in DNA excision repair
Published in Acta crystallographica. Section A, Foundations and advances (07-07-2023)“…Abstract only…”
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An engineered IL-2 partial agonist promotes CD8.sup.+ T cell stemness
Published in Nature (London) (23-09-2021)“…Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients.sup.1. Both…”
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Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri
Published in EMBO reports (01-09-2014)“…Shigella flexneri , the etiological agent of bacillary dysentery, invades the human colonic epithelium and causes its massive inflammatory destruction. Little…”
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Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer
Published in Acta biochimica polonica (01-01-2002)“…Searching for ways to improve the characterization of breast cancer we examined the relationship between the status of the FHIT gene transcript and…”
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Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair
Published in The FASEB journal (01-04-2016)“…Abstract only Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision repair (NER). DNA lesions are initially detected by…”
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An engineered IL-2 partial agonist promotes CD8+ T cell stemness and anti-tumor efficacy
Published in The Journal of immunology (1950) (01-05-2020)“…Adoptive cell transfer of antigen specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in a subset of patients…”
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Inhibition of core histones acetylation by carcinogenic nickel(II)
Published in Molecular and cellular biochemistry (01-11-2005)“…Nickel, a well-established human carcinogen, was shown to decrease acetylation of histones H4 and H3 in cultured cells. Such a decrease is expected to suppress…”
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Ni(II) affects ubiquitination of core histones H2B and H2A
Published in Experimental cell research (15-10-2006)“…The molecular mechanisms of nickel-induced malignant cell transformation include effects altering the structure and covalent modifications of core histones…”
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