Search Results - "Go, Younghoon"

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes by Rahman, Md Habibur, Bhusal, Anup, Kim, Jae-Hong, Jha, Mithilesh Kumar, Song, Gyun Jee, Go, Younghoon, Jang, Il-Sung, Lee, In-Kyu, Suk, Kyoungho

“…Hypothalamic inflammation plays an important role in disrupting feeding behavior and energy homeostasis as well as in the pathogenesis of obesity and diabetes…”
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Atractylodis Rhizoma Alba Attenuates Neuroinflammation in BV2 Microglia upon LPS Stimulation by Inducing HO-1 Activity and Inhibiting NF-κB and MAPK by Jeong, Yun Hee, Li, Wei, Go, Younghoon, Oh, You-Chang

“…Microglial activation and the resulting neuroinflammation are associated with a variety of brain diseases, such as Alzheimer's disease and Parkinson's disease…”
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Regulation of systemic energy homeostasis by serotonin in adipose tissues by Oh, Chang-Myung, Namkung, Jun, Go, Younghoon, Shong, Ko Eun, Kim, Kyuho, Kim, Hyeongseok, Park, Bo-Yoon, Lee, Ho Won, Jeon, Yong Hyun, Song, Junghan, Shong, Minho, Yadav, Vijay K., Karsenty, Gerard, Kajimura, Shingo, Lee, In-Kyu, Park, Sangkyu, Kim, Hail

“…Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy…”
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Angelicae Gigantis Radix Regulates LPS-Induced Neuroinflammation in BV2 Microglia by Inhibiting NF-κB and MAPK Activity and Inducing Nrf-2 Activity by Oh, You-Chang, Jeong, Yun Hee, Li, Wei, Go, Younghoon

“…Angelicae Gigantis Radix (AGR) has been widely used as a traditional medicine in East Asia. The effects of AGR on neuroinflammation have not previously been…”
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Quercus acuta Thunb. Suppresses LPS-Induced Neuroinflammation in BV2 Microglial Cells via Regulating MAPK/NF-κB and Nrf2/HO-1 Pathway by Kim, Jae Kwang, Yang, Hye Jin, Go, Younghoon

“…Microglial activation-mediated neuroinflammation is associated with the pathogenesis of neurodegenerative disorders. Therefore, the management of microglial…”
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Yuk-Gunja-Tang attenuates neuronal death and memory impairment via ERK/CREB/BDNF signaling in the hippocampi of experimental Alzheimer’s disease model by Pak, Malk Eun, Yang, Hye Jin, Li, Wei, Kim, Jae Kwang, Go, Younghoon

“…Yuk-Gunja-Tang (YG) is the Korean traditional medicine in East Asia for gastrointestinal disorders. In the present study, we determined the protective effects…”
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Samhwangsasim-tang attenuates neuronal apoptosis and cognitive decline through BDNF-mediated activation of tyrosin kinase B and p75-neurotrophin receptors by Pak, Malk Eun, Park, Yeo Jin, Yang, Hye Jin, Hwang, Youn-Hwan, Li, Wei, Go, Younghoon

“…Samhwangsasim-tang (SST) is a traditional medicine used to treat hypertension and arteriosclerosis. Additionally, due to the effects of its constituent herbs,…”
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Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis by Jha, Mithilesh Kumar, Song, Gyun Jee, Lee, Maan Gee, Jeoung, Nam Ho, Go, Younghoon, Harris, Robert A, Park, Dong Ho, Kook, Hyun, Lee, In-Kyu, Suk, Kyoungho

“…Pyruvate dehydrogenase kinases (PDK1-4) are mitochondrial metabolic regulators that serve as decision makers via modulation of pyruvate dehydrogenase (PDH)…”
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Novel insights into regulators and functional modulators of adipogenesis by Kim, Hyun-Yong, Jang, Hyun-Jun, Muthamil, Subramanian, Shin, Ung Cheol, Lyu, Ji-Hyo, Kim, Seon-Wook, Go, Younghoon, Park, Seong-Hoon, Lee, Hee Gu, Park, Jun Hong

“…Adipogenesis is a process that differentiates new adipocytes from precursor cells and is tightly regulated by several factors, including many transcription…”
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PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels by Park, Bo-Yoon, Jeon, Jae-Han, Go, Younghoon, Ham, Hye Jin, Kim, Jeong-Eun, Yoo, Eun Kyung, Kwon, Woong Hee, Jeoung, Nam-Ho, Jeon, Yong Hyun, Koo, Seung-Hoi, Kim, Byung-Gyu, He, Ling, Park, Keun-Gyu, Harris, Robert A, Lee, In-Kyu

“…In fasting or diabetes, gluconeogenic genes are transcriptionally activated by glucagon stimulation of the cAMP-protein kinase A (PKA)-CREB signaling pathway…”
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Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue by Lee, Jae-Ho, Go, Younghoon, Kim, Do-Young, Lee, Sun Hee, Kim, Ok-Hee, Jeon, Yong Hyun, Kwon, Taeg Kyu, Bae, Jae-Hoon, Song, Dae-Kyu, Rhyu, Im Joo, Lee, In-Kyu, Shong, Minho, Oh, Byung-Chul, Petucci, Christopher, Park, Jeen-Woo, Osborne, Timothy F., Im, Seung-Soon

“…Isocitrate dehydrogenase 2 (IDH2) is an NADP + -dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the…”
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Banhasasim-Tang Attenuates Lipopolysaccharide-Induced Cognitive Impairment by Suppressing Neuroinflammation in Mice by Oh, You-Chang, Jeong, Yun Hee, Pak, Malk Eun, Go, Younghoon

“…Banhasasim-tang (BHS) is an herbal medicine that has been widely used in East Asia to treat various symptoms associated with upper abdomen swelling. BHS has…”
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ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes by Lee, Hyein, Cho, Sukhee, Kim, Mi-Jin, Park, Yeo Jin, Cho, Eunji, Jo, Yeon Suk, Kim, Yong-Seok, Lee, Jung Yi, Thoudam, Themis, Woo, Seung-Hwa, Lee, Se-In, Jeon, Juyeong, Lee, Young-Sam, Suh, Byung-Chang, Yoon, Jong Hyuk, Go, Younghoon, Lee, In-Kyu, Seo, Jinsoo

“…Recent developments in genome sequencing have expanded the knowledge of genetic factors associated with late-onset Alzheimer’s disease (AD). Among them,…”
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Understanding the relationship between cancer associated cachexia and hypoxia-inducible factor-1 by Muthamil, Subramanian, Kim, Hyun Yong, Jang, Hyun-Jun, Lyu, Ji-Hyo, Shin, Ung Cheol, Go, Younghoon, Park, Seong-Hoon, Lee, Hee Gu, Park, Jun Hong

“…Cancer-associated cachexia (CAC) is a multifactorial disorder characterized by an unrestricted loss of body weight as a result of muscle and adipose tissue…”
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Unlocking Prognostic Genes and Multi-Targeted Therapeutic Bioactives from Herbal Medicines to Combat Cancer-Associated Cachexia: A Transcriptomics and Network Pharmacology Approach by Muthamil, Subramanian, Muthuramalingam, Pandiyan, Kim, Hyun-Yong, Jang, Hyun-Jun, Lyu, Ji-Hyo, Shin, Ung Cheol, Go, Younghoon, Park, Seong-Hoon, Lee, Hee Gu, Shin, Hyunsuk, Park, Jun Hong

“…Cachexia is a devastating fat tissue and muscle wasting syndrome associated with every major chronic illness, including cancer, chronic obstructive pulmonary…”
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Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis by Go, Younghoon, Jeong, Ji Yun, Jeoung, Nam Ho, Jeon, Jae-Han, Park, Bo-Yoon, Kang, Hyeon-Ji, Ha, Chae-Myeong, Choi, Young-Keun, Lee, Sun Joo, Ham, Hye Jin, Kim, Byung-Gyu, Park, Keun-Gyu, Park, So Young, Lee, Chul-Ho, Choi, Cheol Soo, Park, Tae-Sik, Lee, W N Paul, Harris, Robert A, Lee, In-Kyu

“…Hepatic steatosis is associated with increased insulin resistance and tricarboxylic acid (TCA) cycle flux, but decreased ketogenesis and pyruvate dehydrogenase…”
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Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α by Jung, Hoe-Yune, Lee, Dongyeop, Ryu, Hye Guk, Choi, Bo-Hwa, Go, Younghoon, Lee, Namgyu, Lee, Dohyun, Son, Heehwa G., Jeon, Jongsu, Kim, Seong-Hoon, Yoon, Jong Hyuk, Park, Seon-Min, Lee, Seung-Jae V., Lee, In-Kyu, Choi, Kwan Yong, Ryu, Sung Ho, Nohara, Kazunari, Yoo, Seung-Hee, Chen, Zheng, Kim, Kyong-Tai

“…Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated…”
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Coumarin and Moracin Derivatives from Mulberry Leaves ( Morus alba L.) with Soluble Epoxide Hydrolase Inhibitory Activity by Li, Hong Xu, Heo, Myungsook, Go, Younghoon, Kim, Young Soo, Kim, Young Ho, Yang, Seo Young, Li, Wei

“…This study identified three coumarins ( - ), and six moracin derivatives ( - ). The structures of these natural compounds were determined by the spectroscopic…”
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Ginsenoside Rg5, a potent agonist of Nrf2, inhibits HSV-1 infection-induced neuroinflammation by inhibiting oxidative stress and NF-κB activation by Kim, Buyun, Kim, Young Soo, Li, Wei, Kwon, Eun-Bin, Chung, Hwan-Suck, Go, Younghoon, Choi, Jang-Gi

“…Herpes simplex virus type 1 (HSV-1), known to latently infect the host’s trigeminal ganglion, can lead to severe herpes encephalitis or asymptomatic infection,…”
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Menthae Herba Attenuates Neuroinflammation by Regulating CREB/Nrf2/HO-1 Pathway in BV2 Microglial Cells by Park, Yeo Jin, Yang, Hye Jin, Li, Wei, Oh, You-Chang, Go, Younghoon

“…Chronic inflammation and oxidative stress cause microglia to be abnormally activated in the brain, resulting in neurodegenerative diseases such as Alzheimer's…”
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