Search Results - "Go, Rodney C"
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Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity
Published in BMC neuroscience (10-07-2020)“…Parkinson's disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence…”
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The reasons for geographic and racial differences in stroke study: objectives and design
Published in Neuroepidemiology (01-01-2005)“…The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study is a national, population-based, longitudinal study of 30,000 African-American and…”
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Comparison of measures of marker informativeness for ancestry and admixture mapping
Published in BMC genomics (20-12-2011)“…Admixture mapping is a powerful gene mapping approach for an admixed population formed from ancestral populations with different allele frequencies. The power…”
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A comprehensive genetic association study of Alzheimer disease in African Americans
Published in Archives of neurology (Chicago) (01-12-2011)“…To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide…”
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Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
Published in Science (American Association for the Advancement of Science) (22-12-2000)“…Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the…”
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Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure
Published in Schizophrenia bulletin (01-11-2012)“…Genome-wide association studies (GWAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as…”
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Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS): Evidence for Impairment and Heritability of Neurocognitive Functioning in Families of Schizophrenia Patients
Published in The American journal of psychiatry (01-04-2010)“…ObjectiveNeurocognitive impairments in schizophrenia are well replicated and widely regarded as candidate endophenotypes that may facilitate understanding of…”
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Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study
Published in JAMA psychiatry (Chicago, Ill.) (01-05-2016)“…DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. To scan genome-wide…”
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Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (05-11-2005)“…Probands with late onset Alzheimer's disease (LOAD) exhibit positive symptoms of psychosis, 30–60% of the time. Positive symptoms of psychosis have been shown…”
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Genetic Association of Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) With Alzheimer's Disease
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (05-04-2008)“…Brain‐derived neurotrophic factor (BDNF)/tyrosine receptor kinase (TRK) signaling pathway activates a wide range of downstream intracellular cascades,…”
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A genomic scan for age at onset of alzheimer's disease in 437 families from the NIMH genetic initiative
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (05-09-2008)“…We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset…”
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Database mining for selection of SNP markers useful in admixture mapping
Published in BioData mining (14-02-2009)“…New technologies make it possible for the first time to genotype hundreds of thousands of SNPs simultaneously. A wealth of genomic information in the form of…”
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Regional Differences in Diabetes as a Possible Contributor to the Geographic Disparity in Stroke Mortality : The REasons for Geographic And Racial Differences in Stroke Study
Published in Stroke (1970) (01-06-2008)“…Diabetes and hypertension impart approximately the same increased relative risk for stroke, although hypertension has a larger population-attributable risk…”
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Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods
Published in Schizophrenia research (01-10-2006)“…The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic…”
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Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (05-07-2006)“…The chromosome 10q region has recently received a great deal of attention in late‐onset Alzheimer's disease (LOAD), given the growing evidence of linkage to…”
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“Are We There Yet?”: Deciding When One Has Demonstrated Specific Genetic Causation in Complex Diseases and Quantitative Traits
Published in American journal of human genetics (01-10-2003)“…Although mathematical relationships can be proven by deductive logic, biological relationships can only be inferred from empirical observations. This is a…”
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Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS
Published in Fertility and sterility (01-01-2001)“…To determine the rate of clinically evident polycystic ovary syndrome (PCOS) among first-degree female relatives within families with a proband affected by…”
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Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (05-03-2007)“…Other than the APOE peak at 19q13, the 9q22 region was identified in our original genomic scan as the candidate region with the highest multipoint lod score…”
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African-american community attitudes and perceptions toward schizophrenia and medical research : An exploratory study
Published in Journal of the National Medical Association (2006)“…Ensuring adequate representation of all demographic groups in medical research is necessary in order to ensure that the benefits associated with participation…”
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Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)
Published in Clinical Immunology (01-06-2006)“…To test whether MHC alleles associated with common variable immune deficiency (CVID) might also be over-represented in patients with normal serum…”
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