Search Results - "Go, Minnie Y Y"

CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer by Gao, Shanshan, Soares, Fraser, Wang, Shiyan, Wong, Chi Chun, Chen, Huarong, Yang, Zhenjie, Liu, Weixin, Go, Minnie Y. Y., Ahmed, Musaddeque, Zeng, Yong, O’Brien, Catherine Adell, Sung, Joseph J. Y., He, Housheng Hansen, Yu, Jun

“…Cancer stem cells (CSCs) are responsible for tumor progression, recurrence, and drug resistance. To identify genetic vulnerabilities of colon cancer, we…”
Get full text

Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma by Tian, Yuan, Wong, Vincent W S, Wong, Grace L H, Yang, Weiqin, Sun, Hanyong, Shen, Jiayun, Tong, Joanna H M, Go, Minnie Y Y, Cheung, Yue S, Lai, Paul B S, Zhou, Mingyan, Xu, Gang, Huang, Tim H M, Yu, Jun, To, Ka F, Cheng, Alfred S L, Chan, Henry L Y

“…The growing epidemic of obesity, which causes nonalcoholic fatty liver disease (NAFLD) and the more severe phenotype nonalcoholic steatohepatitis (NASH), has…”
Get full text

Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway by Liu, Weili, Li, Xiaoxing, Chu, Eagle S.H., Go, Minnie Y.Y., Xu, Lixia, Zhao, Guijun, Li, Lili, Dai, Ning, Si, Jianmin, Tao, Qian, Sung, Joseph J.Y., Yu, Jun

“…The paired box 5 (PAX5) is a member of PAX transcription factors family involved in the regulation of embryonic development. However, the role of PAX5 in…”
Get full text

Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation by Qian, Yun, Wong, Chi Chun, Xu, Jiaying, Chen, Huarong, Zhang, Yanquan, Kang, Wei, Wang, Hua, Zhang, Li, Li, Weilin, Chu, Eagle S H, Go, Minnie Y Y, Chiu, Philip W Y, Ng, Enders K W, Chan, Francis K L, Sung, Joseph J Y, Si, Jianmin, Yu, Jun

“…There remains a paucity of functional biomarkers in gastric cancer. Here, we report the identification of the sodium channel subunit SCNN1B as a candidate…”
Get full text

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro by Wang, Jia, Zhao, Jingmin, Chu, Eagle SH, Mok, Myth TS, Go, Minnie YY, Man, Kwan, Heuchel, Rainer, Lan, Hui Yao, Chang, Zhijie, Sung, Joseph JY, Yu, Jun

“…Smad7 is a principal inhibitor of the TGFβ–Smad signalling pathway. We have investigated the functional significance of Smad7 in hepatocellular carcinoma…”
Get full text

Zinc finger E‐box binding factor 1 plays a central role in regulating Epstein‐Barr virus (EBV) latent‐lytic switch and acts as a therapeutic target in EBV‐associated gastric cancer by Zhao, Junhong, Jin, Hongchuan, Cheung, Kin Fai, Tong, Joanna H. M., Zhang, Sui, Go, Minnie Y. Y., Tian, Linwei, Kang, Wei, Leung, Patrick P. S., Zeng, Zhirong, Li, Xiaoxing, To, Ka Fai, Sung, Joseph J. Y., Yu, Jun

“…BACKGROUND: The role of Epstein‐Barr virus (EBV) infection in gastric carcinogenesis remains largely unknown. The authors studied the effects of zinc finger…”
Get full text

Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival by Xu, Lixia, Li, Xiaoxing, Chu, Eagle S H, Zhao, Guijun, Go, Minnie Y Y, Tao, Qian, Jin, Hongchuan, Zeng, Zhirong, Sung, Joseph J Y, Yu, Jun

“…Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member B (BCL6B) was found to be preferentially methylated in cancer. A study was…”
Get more information

Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer by Otani, Koji, Dong, Yujuan, Li, Xiaoxing, Lu, Jing, Zhang, Ning, Xu, Lixia, Go, Minnie YY, Ng, Enders KW, Arakawa, Tetsuo, Chan, Francis KL, Sung, Joseph JY, Yu, Jun

“…We report that the odd‐skipped related 1 (OSR1) gene encoding a zinc‐finger transcription factor was preferentially methylated in gastric cancer by genome‐wide…”
Get full text

Cyclooxygenase-2 Expression in Helicobacter pylori-Associated Premalignant and Malignant Gastric Lesions by Sung, Joseph J.Y., Leung, Wai K., Go, Minnie Y.Y., To, Ka F., Cheng, Alfred S.L., Ng, Enders K.W., Chan, Francis K.L.

“…Expression of cyclooxygenase-2 (COX-2) in various stages of the Helicobacter pylori- associated gastric carcinogenesis pathway has not been elucidated. We…”
Get full text

Effects of Helicobacter pylori Eradication on Methylation Status of E-Cadherin Gene in Noncancerous Stomach by Leung, Wai K, Man, Ellen P S, Yu, Jun, Go, Minnie Y Y, To, Ka-fai, Yamaoka, Yoshio, Cheng, Victoria Y Y, Ng, Enders K W, Sung, Joseph J Y

“…Purpose: Promoter hypermethylation of E-cadherin plays an important role on gastric cancer development. Whereas E-cadherin methylation was frequently detected…”
Get full text

Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target by Liu, Dabin, Wong, Chi Chun, Zhou, Yunfei, Li, Chuangen, Chen, Huarong, Ji, Fenfen, Go, Minnie Y.Y., Wang, Feixue, Su, Hao, Wei, Hong, Cai, Zongwei, Wong, Nathalie, Wong, Vincent W.S., Yu, Jun

“…Squalene epoxidase (SQLE) is the rate-limiting enzyme for cholesterol biosynthesis. We elucidated the functional significance, molecular mechanisms, and…”
Get full text

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy by Zhang, Xiang, Han, Juqiang, Man, Kwan, Li, Xiaoxing, Du, Jinghua, Chu, Eagle S.H, Go, Minnie Y.Y, Sung, Joseph J.Y, Yu, Jun

“…Graphical abstract…”
Get full text

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis by Zhang, Xiang, Shen, Jiayun, Man, Kwan, Chu, Eagle S.H, Yau, Tung On, Sung, Joanne C.Y, Go, Minnie Y.Y, Deng, Jun, Lu, Liwei, Wong, Vincent W.S, Sung, Joseph J.Y, Farrell, Geoffrey, Yu, Jun

“…Background & Aims Perpetuate liver inflammation is crucial in the pathogenesis of non-alcoholic steatohepatitis (NASH). Expression of CXCL10, a…”
Get full text

APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target by Chen, Huarong, Wong, Chi-Chun, Liu, Dabin, Go, Minnie Y Y, Wu, Bin, Peng, Sui, Kuang, Ming, Wong, Nathalie, Yu, Jun

“…: The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process contributed by the accumulation of molecular alterations. We identified Apelin…”
Get full text

SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate by Wong, Chi Chun, Qian, Yun, Li, Xiaona, Xu, Jiaying, Kang, Wei, Tong, Joanna H, To, Ka-Fai, Jin, Ye, Li, Weilin, Chen, Huarong, Go, Minnie Y.Y, Wu, Jian-Lin, Cheng, Ka Wing, Ng, Simon S.M, Sung, Joseph J.Y, Cai, Zongwei, Yu, Jun

“…Background & Aims Many colorectal cancer (CRC) cells contain mutations in KRAS. Analyses of CRC cells with mutations in APC or CTNNB1 and KRAS identified…”
Get full text

Glucose-regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus by Ma, Yan, Yu, Jun, Chan, Henry L.Y., Chen, Yang-chao, Wang, Hua, Chen, Ying, Chan, Chu-yan, Go, Minnie Y.Y., Tsai, Sau-na, Ngai, Sai-ming, To, Ka-fai, Tong, Joanna H.M., He, Qing-Yu, Sung, Joseph J.Y., Kung, Hsiang-fu, Cheng, Christopher H.K., He, Ming-liang

“…Hepatitis B virus (HBV) infection is a global public health problem that plays a crucial role in the pathogenesis of chronic hepatitis, cirrhosis, and…”
Get full text

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway by Wang, Jia, Chu, Eagle S H, Chen, Hai-Yong, Man, Kwan, Go, Minnie Y Y, Huang, Xiao Ru, Lan, Hui Yao, Sung, Joseph J Y, Yu, Jun

“…microRNA-29b (miR-29b) is known to be associated with TGF-β-mediated fibrosis, but the mechanistic action of miR-29b in liver fibrosis remains unclear and is…”
Get full text

MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome by Wang, Kunning, Liang, Qiaoyi, Li, Xiaoxing, Tsoi, Ho, Zhang, Jingwan, Wang, Hua, Go, Minnie Y Y, Chiu, Philip W Y, Ng, Enders K W, Sung, Joseph J Y, Yu, Jun

“…Using the promoter methylation assay, we have shown that MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is preferentially methylated in…”
Get more information

Helicobacter pylori Causes Epigenetic Dysregulation of FOXD3 to Promote Gastric Carcinogenesis by Cheng, Alfred S.L, Li, May S, Kang, Wei, Cheng, Victoria Y, Chou, Jian–Liang, Lau, Suki S, Go, Minnie Y, Lee, Ching C, Ling, Thomas K, Ng, Enders K, Yu, Jun, Huang, Tim H, To, Ka F, Chan, Michael W, Sung, Joseph J.Y, Chan, Francis K.L

“…Background & Aims Deregulation of forkhead box (Fox) proteins, an evolutionarily conserved family of transcriptional regulators, leads to tumorigenesis. Little…”
Get full text

Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis by Zhang, Jingwan, Tsoi, Ho, Li, Xiaoxing, Wang, Hua, Gao, Jing, Wang, Kunning, Go, Minnie Yy, Ng, Siew C, Chan, Francis Kl, Sung, Joseph Jy, Yu, Jun

“…We found that carbonic anhydrase IV (CA4), a member of the carbonic anhydrases, is silenced in colorectal cancer (CRC). We analysed its epigenetic…”
Get more information