Search Results - "Go, Eden"

Enabling Lipidomic Biomarker Studies for Protected Populations by Combining Noninvasive Fingerprint Sampling with MS Analysis and Machine Learning by Isom, Madeline, Go, Eden P., Desaire, Heather

“…Triacylglycerols and wax esters are two lipid classes that have been linked to diseases, including autism, Alzheimer’s disease, dementia, cardiovascular…”
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Glycosylation and Disulfide Bond Analysis of Transiently and Stably Expressed Clade C HIV‑1 gp140 Trimers in 293T Cells Identifies Disulfide Heterogeneity Present in Both Proteins and Differences in O‑Linked Glycosylation by Go, Eden P, Hua, David, Desaire, Heather

“…The HIV-1 envelope protein (Env) mediates viral entry into host cells to initiate infection and is the sole target of antibody-based vaccine development…”
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The Aristotle Classifier: Using the Whole Glycomic Profile To Indicate a Disease State by Hua, David, Patabandige, Milani Wijeweera, Go, Eden P, Desaire, Heather

“…“The totality is not, as it were, a mere heap, but the whole is something besides the parts.”Aristotle. We built a classifier that uses the totality of the…”
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Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein by Zhang, Shijian, Go, Eden P, Ding, Haitao, Anang, Saumya, Kappes, John C, Desaire, Heather, Sodroski, Joseph G

“…The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells. The S…”
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Advances, obstacles, and opportunities for machine learning in proteomics by Desaire, Heather, Go, Eden P., Hua, David

“…The fields of proteomics and machine learning are both large disciplines, each producing well over 5,000 publications per year. However, studies combining both…”
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Clinically Viable Assay for Monitoring Uromodulin Glycosylation by Patabandige, Milani Wijeweera, Go, Eden P, Desaire, Heather

“…Uromodulin, also known as the Tamm–Horsfall protein or THP, is the most abundant protein excreted in human urine. It is associated with the progression of…”
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Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers by Go, Eden P, Ding, Haitao, Zhang, Shijian, Ringe, Rajesh P, Nicely, Nathan, Hua, David, Steinbock, Robert T, Golabek, Michael, Alin, James, Alam, S Munir, Cupo, Albert, Haynes, Barton F, Kappes, John C, Moore, John P, Sodroski, Joseph G, Desaire, Heather

“…HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes,…”
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Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140 by Go, Eden P, Herschhorn, Alon, Gu, Christopher, Castillo-Menendez, Luis, Zhang, Shijian, Mao, Youdong, Chen, Haiyan, Ding, Haitao, Wakefield, John K, Hua, David, Liao, Hua-Xin, Kappes, John C, Sodroski, Joseph, Desaire, Heather

“…The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, which consists of the gp120 and gp41 subunits, is the focus of multiple…”
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Mass Spectrometry-Based Disulfide Mapping of Lysyl Oxidase-like 2 by Meier, Alex A, Go, Eden P, Moon, Hee-Jung, Desaire, Heather, Mure, Minae

“…Lysyl oxidase-like 2 (LOXL2) catalyzes the oxidative deamination of peptidyl lysines and hydroxylysines to promote extracellular matrix remodeling. Aberrant…”
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New Glycoproteomics Software, GlycoPep Evaluator, Generates Decoy Glycopeptides de Novo and Enables Accurate False Discovery Rate Analysis for Small Data Sets by Zhu, Zhikai, Su, Xiaomeng, Go, Eden P, Desaire, Heather

“…Glycoproteins are biologically significant large molecules that participate in numerous cellular activities. In order to obtain site-specific protein…”
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Absolute Quantitation of Glycosylation Site Occupancy Using Isotopically Labeled Standards and LC-MS by Zhu, Zhikai, Go, Eden P., Desaire, Heather

“…N-linked glycans are required to maintain appropriate biological functions on proteins. Underglycosylation leads to many diseases in plants and animals;…”
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The opportunity cost of automated glycopeptide analysis: case study profiling the SARS-CoV-2 S glycoprotein by Go, Eden P., Zhang, Shijian, Ding, Haitao, Kappes, John C., Sodroski, Joseph, Desaire, Heather

“…Glycosylation analysis of viral glycoproteins contributes significantly to vaccine design and development. Among other benefits, glycosylation analysis allows…”
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Recombinant Human Lysyl Oxidase-like 2 Secreted from Human Embryonic Kidney Cells Displays Complex and Acidic Glycans at All Three N-Linked Glycosylation Sites by Go, Eden P, Moon, Hee-Jung, Mure, Minae, Desaire, Heather

“…Human lysyl oxidase-like 2 (hLOXL2), a glycoprotein implicated in tumor progression and organ fibrosis, is a molecular target for anticancer and antifibrosis…”
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How to Apply Supervised Machine Learning Tools to MS Imaging Files: Case Study with Cancer Spheroids Undergoing Treatment with the Monoclonal Antibody Cetuximab by Hua, David, Liu, Xin, Go, Eden P, Wang, Yijia, Hummon, Amanda B, Desaire, Heather

“…As the field of mass spectrometry imaging continues to grow, so too do its needs for optimal methods of data analysis. One general need in image analysis is…”
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Method for Quantifying Oxidized Methionines and Application to HIV-1 Env by Shipman, Joshua T., Go, Eden P., Desaire, Heather

“…Recombinantly expressed proteins are susceptible to oxidation during expression, purification, storage, and analysis; the residue most susceptible to oxidation…”
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Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer by Zhang, Peng, Gorman, Jason, Geng, Hui, Liu, Qingbo, Lin, Yin, Tsybovsky, Yaroslav, Go, Eden P., Dey, Barna, Andine, Tsion, Kwon, Alice, Patel, Mit, Gururani, Deepali, Uddin, Ferzan, Guzzo, Christina, Cimbro, Raffaello, Miao, Huiyi, McKee, Krisha, Chuang, Gwo-Yu, Martin, Loïc, Sironi, Francesca, Malnati, Mauro S., Desaire, Heather, Berger, Edward A., Mascola, John R., Dolan, Michael A., Kwong, Peter D., Lusso, Paolo

“…The HIV-1 envelope (Env) spike is a trimer of gp120/gp41 heterodimers that mediates viral entry. Binding to CD4 on the host cell membrane is the first…”
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Database Resources in Metabolomics: An Overview by Go, Eden P.

“…Metabolomics is the characterization, identification, and quantitation of metabolites resulting from a wide range of biochemical processes in living systems…”
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Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV‑1 gp120 Envelope Proteins by Go, Eden P, Liao, Hua-Xin, Alam, S. Munir, Hua, David, Haynes, Barton F, Desaire, Heather

“…Glycosylation plays an essential role in regulating protein function by modulating biological, structural, and therapeutic properties. However, due to its…”
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cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate by Dey, Antu K., Cupo, Albert, Ozorowski, Gabriel, Sharma, Vaneet K., Behrens, Anna‐Janina, Go, Eden P., Ketas, Thomas J., Yasmeen, Anila, Klasse, Per J., Sayeed, Eddy, Desaire, Heather, Crispin, Max, Wilson, Ian A., Sanders, Rogier W., Hassell, Thomas, Ward, Andrew B., Moore, John P.

“…We describe the properties of BG505 SOSIP.664 HIV‐1 envelope glycoprotein trimers produced under current Good Manufacturing Practice (cGMP) conditions. These…”
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Native Conformation and Canonical Disulfide Bond Formation Are Interlinked Properties of HIV-1 Env Glycoproteins by Go, Eden P, Cupo, Albert, Ringe, Rajesh, Pugach, Pavel, Moore, John P, Desaire, Heather

“…We investigated whether there is any association between a native-like conformation and the presence of only the canonical (i.e., native) disulfide bonds in…”
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