SPECIFICITIES OF THE SUBSET PROFILE OF PERIPHERAL BLOOD IN PATIENTS WITH GLIOBLASTOMA: PATHOGENETIC AND CLINICAL ASSESSMENTS

In glioblastoma (GB), it is necessary to take into consideration GB-associated secondary immunodeficiency (SID), so-called syndrome of tumor-associated SID (STASID). Cell subsets having effector and regulatory functions, play an important role in developing STASID, and their proportions in patients...

Full description

Saved in:

Bibliographic Details
Published in:	Medit͡s︡inskai͡a︡ immunologii͡a Vol. 8; no. 1; pp. 37 - 50
Main Authors:	Chumakov, V. A., Pronina, O. A., Kachkov, I. A., Korshounov, A. G., Pineguin, B. V., Anan’eva, I. I., Elbeik, T., Metelitsa, L. S., Dorofeev, A. E., Gnouchev, N. V., Souchkov, S. V.
Format:	Journal Article
Language:	English Russian
Published:	St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 21-07-2014
Subjects:	anti-tumor immunity autoimmune syndrome glioblastoma lympholytes subpopulations secondary immunodeficiency
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In glioblastoma (GB), it is necessary to take into consideration GB-associated secondary immunodeficiency (SID), so-called syndrome of tumor-associated SID (STASID). Cell subsets having effector and regulatory functions, play an important role in developing STASID, and their proportions in patients with different forms of GB can be of pathogenetic importance and have clinical value for treatment and rehabilitation scheduling as well. The most pathogenically and clinically important features of cell subsets profile of peripheral blood were analyzed in patients with different clinical and morphological types of GB. The patients were divided into three groups, i.e., groups I and II were formed by patients with STASID (marked and slightly marked SID, accordingly); group III – patients with SIDTAS (tumor-associated autoimmune syndrome, associated with SID). Marked suppression of cell immunity is typical of group I - imbalance in T-lymphocytes, in a number of specific subsets, and in subsets clusters, as well as disproportions in the immunoregulatory indexes. In group II, the subset profiles of blood were slightly different from the norm. In patients with SIDTAS, activation of cell immunity was evident, forming SID with signs of autoimmune syndrome, affecting effector and regulatory chains of immunity, and influencing the severity and forecast of the disease. Specific features of the immune status in patients with GB identified can be resulted from different clinicalmorphological types of the tumor; the latter are to be considered in differential diagnostics of clinical course of GB and in scheduling of clinical-immunological efficient anti-tumor pharmacotherapy in pre- and postoperative periods.
ISSN:	1563-0625 2313-741X
DOI:	10.15789/1563-0625-2006-1-37-50