Search Results - "Gnosa, Sebastian"

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites by Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina B., Refsgaard, Jan C., Gnosa, Sebastian P., Bekker-Jensen, Dorte B., Secher, Anna, Maurya, Svetlana R., Paul, Indranil, Mendez, Blanca L., Kelstrup, Christian D., Francavilla, Chiara, Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars J., Olsen, Jesper V.

“…Tyrosine phosphorylation regulates multi-layered signaling networks with broad implications in (patho)physiology, but high-throughput methods for functional…”
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ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins by Mygind, Kasper J, Nikodemus, Denise, Gnosa, Sebastian, Kweder, Ramya, Albrechtsen, Nicolai J Wewer, Kveiborg, Marie, Erler, Janine T, Albrechtsen, Reidar

“…Desmoplasia is a common feature of aggressive cancers, driven by a complex interplay of protein production and degradation. Basigin is a type 1 integral…”
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Loss of cancer cell‐derived ADAM15 alters the tumor microenvironment in colorectal tumors by Puig‐Blasco, Laia, Piotrowski, Krzysztof B., Michaelsen, Signe R., Bager, Nicolai S., Areškevičiūtė, Aušrinė, Thorseth, Marie‐Louise, Sun, Xiao‐Feng, Keller, Ulrich auf dem, Kristensen, Bjarne W., Madsen, Daniel H., Gnosa, Sebastian P., Kveiborg, Marie

“…Abstract Tumor progression and response to treatment are highly affected by interactions between cancer cells and the tumor microenvironment (TME). Many of the…”
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Identification of ADAM12 as a Novel Basigin Sheddase by Albrechtsen, Reidar, Albrechtsen, Nicolai J Wewer, Gnosa, Sebastian, Schwarz, Jeanette, Dyrskjøt, Lars, Kveiborg, Marie

“…The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matrix metalloproteinase (MMP)-mediated extracellular matrix…”
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ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion by Gnosa, Sebastian P., Puig Blasco, Laia, Piotrowski, Krzysztof B., Freiberg, Marie L., Savickas, Simonas, Madsen, Daniel H., auf dem Keller, Ulrich, Kronqvist, Pauliina, Kveiborg, Marie

“…Macrophages in the tumor microenvironment have a substantial impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can…”
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Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines by Gnosa, Sebastian, Shen, Yang-Mei, Wang, Chao-Jie, Zhang, Hong, Stratmann, Johannes, Arbman, Gunnar, Sun, Xiao-Feng

“…Astrocyte elevated gene 1 (AEG-1), an important oncogene, has been shown to be overexpressed in several types of cancers. In colorectal cancer (CRC), the…”
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Tafazzin protein expression is associated with tumorigenesis and radiation response in rectal cancer: a study of Swedish clinical trial on preoperative radiotherapy by Pathak, Surajit, Meng, Wen-Jian, Zhang, Hong, Gnosa, Sebastian, Nandy, Suman Kumar, Adell, Gunnar, Holmlund, Birgitta, Sun, Xiao-Feng

“…Tafazzin (TAZ), a transmembrane protein contributes in mitochondrial structural and functional modifications through cardiolipin remodeling. TAZ mutations are…”
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Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients by Stratmann, Johannes, Wang, Chao-Jie, Gnosa, Sebastian, Wallin, Asa, Hinselwood, David, Sun, Xiao-Feng, Zhang, Hong

“…Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression of Dicer mRNA in normal mucosa (n = 162), primary…”
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Variants of the PPARD gene and their clinicopathological significance in colorectal cancer by Ticha, Ivana, Gnosa, Sebastian, Lindblom, Annika, Liu, Tao, Sun, Xiao-Feng

“…Peroxisome proliferator-activated receptor delta (PPARD) is nuclear hormone receptor involved in colorectal cancer (CRC) differentiation and progression. The…”
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Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits by Kruse, Thomas, Gnosa, Sebastian Peter, Nasa, Isha, Garvanska, Dimitriya Hristoforova, Hein, Jamin B, Nguyen, Hieu, Samsøe‐Petersen, Jacob, Lopez‐Mendez, Blanca, Hertz, Emil Peter Thrane, Schwarz, Jeanette, Pena, Hanna Sofia, Nikodemus, Denise, Kveiborg, Marie, Kettenbach, Arminja N, Nilsson, Jakob

“…PP2A is an essential protein phosphatase that regulates most cellular processes through the formation of holoenzymes containing distinct regulatory B‐subunits…”
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Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness by Czaplinska, Dominika, Ialchina, Renata, Andersen, Henriette Berg, Yao, Jiayi, Stigliani, Arnaud, Dannesboe, Johs, Flinck, Mette, Chen, Xiaoming, Mitrega, Jakub, Gnosa, Sebastian Peter, Dmytriyeva, Oksana, Alves, Frauke, Napp, Joanna, Sandelin, Albin, Pedersen, Stine Falsig

“…Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with minimal treatment options and a global rise in prevalence. PDAC is…”
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Abstract 702: Development of a radioresistant PDX prostate cancer model to evaluate potential radiosensitizing compounds by Alfsen, Maria Zeiler, Thaysen, Maria, Nielsen, Nikoline, Wick, Michael, Piggott, Luke, Gnosa, Sebastian, Nielsen, Carsten Haagen

“…Abstract Prostate cancer is the second most common cancer diagnosis worldwide and the fifth leading cause of cancer related death among men. Several treatment…”
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The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer by Liu, Na, Cui, Weiyingqi, Jiang, Xia, Zhang, Zhiyong, Gnosa, Sebastian, Ali, Zaheer, Jensen, Lasse, Jönsson, Jan-Ingvar, Blockhuys, Stéphanie, Lam, Eric W.-F., Zhao, Zengren, Ping, Jie, Xie, Ning, Kopsida, Maria, Wang, Xin, Sun, Xiao-Feng

“…To explore whether the Rho protein is involved in the radioresistance of colorectal cancer and investigate the underlying mechanisms. Rho GTPase expression was…”
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ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy by Piotrowski, Krzysztof Bartłomiej, Blasco, Laia Puig, Samsøe-Petersen, Jacob, Eefsen, Rikke Løvendahl, Illemann, Martin, Oria, Victor Oginga, Campos, Karla Iveth Aguilera, Lopresti, Alexia Mélanie, Albrechtsen, Reidar, Sørensen, Claus Storgaard, Sun, Xiao-Feng, Kveiborg, Marie, Gnosa, Sebastian

“…Radiotherapy is one of the most common cancer treatments, yet, some patients require high doses to respond. Therefore, the development of new strategies leans…”
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MTDH genetic variants in colorectal cancer patients by Gnosa, Sebastian, Ticha, Ivana, Haapaniemi, Staffan, Sun, Xiao-Feng

“…The colorectal carcinogenesis is a complex process encompassing genetic alterations. The oncoprotein AEG-1, encoded by the MTDH gene, was shown previously to…”
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Abstract 5039: Development of a prostate cancer PDX model radioresistant to PSMA targeted radionuclide therapy by Thaysen, Maria, Christensen, Esben, Nielsen, Rikke N., Wick, Michael, Wessel, Mette M., Kristensen, Lotte K., Gnosa, Sebastian, Nielsen, Carsten H.

“…Abstract Prostate cancer is the second most common cancer diagnosis worldwide and the fifth leading cause of cancer related death among men. Lutetium Lu 177…”
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Abstract 6902: Development of a stable luciferase expressing PDX-derived cell line for translational in vitro and in vivo testing by Cold, Sigrid, Bøge, Rikke N., Papin, Emma, Michler, Ida T., Kristensen, Lotte K., Engel, Trine B., Kjaer, Andreas, Nielsen, Carsten H., Gnosa, Sebastian

“…Abstract Despite much effort invested in developing novel cancer therapies, more than 90% of clinical studies fail due to toxicity or lack of efficacy in…”
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AEG-1 knockdown in colon cancer cell lines inhibits radiation-enhanced migration and invasion in vitro and in a novel in vivo zebrafish model by Gnosa, Sebastian, Capodanno, Alessandra, Murthy, Raghavendra Vasudeva, Jensen, Lasse Dahl Ejby, Sun, Xiao-Feng

“…Radiotherapy is a well-established anti-cancer treatment. Although radiotherapy has been shown to significantly decrease the local relapse in rectal cancer…”
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Abstract 4897: Genetic variants and expression of AEG-1 in relation to clinical outcome and radiotherapy response in colorectal cancer patients and cell lines by Gnosa, Sebastian, Brodin, Veronika Patcha, Ticha, Ivana, Adell, Gunnar, Arbman, Gunnar, Zhang, Hong, Sun, Xiao-Feng

“…Abstract Background: Colorectal cancer (CRC) is the third most common cancer in men and the second in woman worldwide. The therapy of CRC has been critically…”
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Genetic variants and expression of AEG-1 in relation to clinical outcome and radiotherapy response in colorectal cancer patients and cell lines by Gnosa, Sebastian, Brodin, Veronika Patcha, Ticha, Ivana, Adell, Gunnar, Arbman, Gunnar, Zhang, Hong, Sun, Xiao-Feng

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