Search Results - "Gniffke, Edward P"
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A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2
Published in Frontiers in pharmacology (14-06-2021)“…Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments…”
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Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models
Published in Molecular autism (15-09-2018)“…Autism spectrum disorders (ASDs) are a heterogeneous group of behaviorally defined disorders and are associated with hundreds of rare genetic mutations and…”
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Plasma From Recovered COVID-19 Patients Inhibits Spike Protein Binding to ACE2 in a Microsphere-Based Inhibition Assay
Published in The Journal of infectious diseases (15-12-2020)“…Abstract We present a microsphere-based flow cytometry assay that quantifies the ability of plasma to inhibit the binding of spike protein to…”
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Remodeling of the Homer-Shank interactome mediates homeostatic plasticity
Published in Science signaling (04-05-2021)“…Neurons maintain stable levels of excitability using homeostatic synaptic scaling, which adjusts the strength of a neuron's postsynaptic inputs to compensate…”
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Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states
Published in Cell reports (Cambridge) (30-11-2021)“…A core network of widely expressed proteins within the glutamatergic post-synapse mediates activity-dependent synaptic plasticity throughout the brain, but the…”
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Activity-dependent changes in synaptic protein complex composition are consistent in different detergents despite differential solubility
Published in Scientific reports (26-07-2019)“…At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis…”
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