Search Results - "Gnecco, Dino"

β -Secretase-1: In Silico Drug Reposition for Alzheimer's Disease by Galeana-Ascencio, Roberto A, Mendieta, Liliana, Limon, Daniel I, Gnecco, Dino, Terán, Joel L, Orea, María L, Carrasco-Carballo, Alan

“…The -secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with the development of Alzheimer's…”
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Chiral Indolizinium Salts Derived from 2-Pyridinecarbaldehyde-First Diastereoselective Syntheses of (-)-1- epi- lentiginosine by Rodriguez-Matsui, Hisami, Aparicio, David M, Orea, María L, Juárez, Jorge R, Gómez-Calvario, Victor, Gnecco, Dino, Carrasco-Carballo, Alan, Terán, Joel L

“…The first diastereoselective synthesis of (-)-1- -lentiginosine from a common chiral -epoxyamide derived from 2-pyridincarbaldehyde is reported. This…”
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L-Aspartic acid pyridinium salts: In silico, synthesis and adjuvant vs antibiotic antibacterial evaluation by Gutiérrez Cano, Jessica R., Paulina Morales-Sandoval, I., Gnecco, Dino, Carrasco-Carballo, Alan, Terán, Joel L.

“…[Display omitted] •L-Aspartic pyr salts can cross membranes and affect CATIII, DNA GyrB and TryRS.•L-Aspartic pyr salts are effective as antibiotics with MIC…”
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Efficient Synthesis of Chiral 5-Methoxycarbonylpyridin-2(1H)-ones and 3-Bromo-5-methoxycarbonylpyridin-2(1H)-ones by Gnecco, Dino, L. Orea, María, Pilotzi, Hugo, M. Aparicio, David, R. Juárez, Jorge, L. Terán, Joel

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1H and 13C NMR characterization of new cycloartane triterpenes from Mangifera indica by Escobedo-Martínez, Carolina, Concepción Lozada, M., Hernández-Ortega, Simón, Villarreal, María Luisa, Gnecco, Dino, Enríquez, Raúl G., Reynolds, William

“…From the stem bark of Mangifera indica, seven cycloartane‐type secondary metabolites were isolated. Compound 1 has been isolated for the first time from M…”
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Retro-Curcuminoids as Mimics of Dehydrozingerone and Curcumin: Synthesis, NMR, X-ray, and Cytotoxic Activity by Obregón-Mendoza, Marco A, Estévez-Carmona, María Mirian, Hernández-Ortega, Simón, Soriano-García, Manuel, Ramírez-Apan, María Teresa, Orea, Laura, Pilotzi, Hugo, Gnecco, Dino, Cassani, Julia, Enríquez, Raúl G

“…Curcumin and its derivatives have been extensively studied for their remarkable medicinal properties, and their chemical synthesis has been an important step…”
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Diastereospecific Intramolecular Cyclopropanation of Enantiopure 8-Bromo-3-phenylhexahydrooxazolo[3,2-a]pyridin-5-ones by L. Orea, María, Gnecco, Dino, Vargas, Anna, M. Aparicio, David, L. Terán, Joel, R. Juárez, Jorge

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Diastereoselective Approach to cis-4-Methyl/thiol-Pipecolic Esters Based on RCM Reaction and Conjugate Michael Addition by Zárate, Araceli, Orea, Laura, Juárez, Jorge R., Castro, Alejandro, Mendoza, Angel, Gnecco, Dino, Terán, Joel L.

“…A synthetic route for the access to enantiopure cis-4-methyl/thiol-pipecolic esters is presented. It is based on the ring-closing metathesis reaction to build…”
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Application of amide-stabilized sulfur ylide reactivity to the stereodivergent synthesis of ( R, S)- and ( S, R)-reboxetine by Aparicio, David M., Terán, Joel L., Gnecco, Dino, Galindo, Alberto, Juárez, Jorge R., Orea, María L., Mendoza, Angel

“…A simple access to ( R, S)- and ( S, R)-reboxetine from a single chiral sulfonium salt 4 is reported. This approach, based on a stabilized sulfur…”
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4-Hydroxy-1,1′-bis[( S )-1-phenylethyl]-5,5′,6,6′-tetrahydro-3,4′-bipyridine-2,2′(1 H ,1′ H )-dione by Romero, Nancy, Gnecco, Dino, Terán, Joel, Bernès, Sylvain

“…The title bis-piperidine, C26H28N2O3, was unexpectedly obtained via a dimerization mechanism promoted by acetic acid when performing the Dieckmann cyclization…”
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Crystal structures of two chiral piperidine derivatives: 1-[(1 R )-2-hydroxy-1-phenylethyl]piperidin-4-one and 8-[(1 S )-1-phenylethyl]-1,4-dioxa-8-azaspiro[4.5]decane-7-thione by Romero, Nancy, Bernès, Sylvain, Roa, Luis F., Terán, Joel L., Gnecco, Dino

“…The crystal structures of the two title piperidine derivatives show different conformations for the six-membered heterocycle. The N -substituted 4-piperidinone…”
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An Enantioselective Access to 1-Alkyl-1,2,3,4-tetrahydroisoquinolines. Application to a New Synthesis of (−)-Argemonine by Youte, Jean-Jacques, Barbier, Denis, Al-Mourabit, Ali, Gnecco, Dino, Marazano, Christian

“…Potassium ferricyanide oxidation of salt 1 gave isoquinolinone 7 whose treatment with Grignard reagents resulted in a high-yield formation of substituted…”
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(1′ S ,2 R ,3 R )-(−)-2-Hydroxy-3-morpholino-3-phenyl- N -(1′-phenylethyl)propionamide by Mendoza, Angel, Aparicio, David M., Terán, Joel L., Gnecco, Dino, Juárez, Jorge R.

“…In the title compound, C21H26N2O3, the morpholine ring has a chair conformation and the dihedral angle between the two phenyl rings is 59.0 (3)°…”
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Synthesis of an aspidosperma alkaloid precursor: synthesis of (+)-aspidospermidine by Gnecco, Dino, Vázquez, Edna, Galindo, Alberto, Terán, Joel L., Orea, Laura, Bernès, Sylvain, Enríquez, R.G.

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Preparation of (R)-(+)-3-Phenyl-2,3,5,6,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ylium Bromide: Synthesis of (S)-(+)-Coniine, (R)-(-)-Coniceine and (R)-(+)-Anabasine by L. Terán, Joel, R. Juárez, Jorge, Castro, Alejandro, Orea, Laura, Galindo, Alberto, Gnecco, Dino, Ramírez, Johana

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Iβ/I-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease by Galeana-Ascencio, Roberto A, Mendieta, Liliana, Limon, Daniel I, Gnecco, Dino, Terán, Joel L, Orea, María L, Carrasco-Carballo, Alan

“…The β-secretase-1 enzyme (BACE-1) performs a key role in the production of beta-Amyloid protein (Aβ), which is associated with the development of Alzheimer's…”
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Diastereoselective Functionalization of Chiral N‐Acyl‐1,3‐oxazolidines and Their Applications in the Synthesis of Bioactive Molecules by Morales‐Monarca, Gerardo H., Gnecco, Dino, Terán, Joel L.

“…1,3‐Oxazolidines, derived from widely available enantiomerically pure 1,2‐aminoalcohols, are versatile chiral auxiliaries for several key transformations,…”
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Chiral Indolizinium Salts Derived from 2-Pyridinecarbaldehyde—First Diastereoselective Syntheses of -1-Iepi-/Ilentiginosine by Rodriguez-Matsui, Hisami, Aparicio, David M, Orea, María L, Juárez, Jorge R, Gómez-Calvario, Victor, Gnecco, Dino, Carrasco-Carballo, Alan, Terán, Joel L

“…The first diastereoselective synthesis of (−)-1-epi-lentiginosine from a common chiral trans-epoxyamide derived from 2-pyridincarbaldehyde is reported. This…”
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Crystal Structure of an Unexpected Derivative of Curcumin: 2-[2-(4-Acetoxy-3-methoxyphenyl)ethyl]benzothiazole by LOZADA, M. CONCEPCIÓN, ENRÍQUEZ, Raúl G., ORTÍZ, Benjamin, GNECCO, Dino, SORIANO-GARCÍA, Manuel

“…C18H15NO3S is orthorhombic, P212121. The unit-cell dimensions at 293 K are a = 7.182(1), b = 11.100(1), c = 20.644(2)Å, V = 1645.7(3)Å3, Dx = 1.313 g/cm3, and…”
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Boron trifluoride etherate for regioselective rearrangement or opening of secondary aryl glycidic amides by Aparicio, David M., Tépox-Luna, Dulce, Bedolla-Medrano, Mercedes, Gnecco, Dino, Juárez, Jorge R., Mendoza, Ángel, Orea, María L., Terán, Joel L.

“…A regioselective 1,2-acyl, 1,2-hydrogen migration, and intermolecular opening of secondary aryl glycidic amides catalyzed by BF3·OEt2 were investigated…”
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