Search Results - "Gnanapragassam, Vinayaga S"

Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets by Chugh, Seema, Gnanapragassam, Vinayaga S., Jain, Maneesh, Rachagani, Satyanarayana, Ponnusamy, Moorthy P., Batra, Surinder K.

“…Mucins are large glycoproteins expressed on the epithelia that provide a protective barrier against harsh insults from toxins and pathogenic microbes. These…”
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Neuroprotective and neuroregenerative effects of nimodipine in a model system of neuronal differentiation and neurite outgrowth by Bork, Kaya, Wurm, Franziska, Haller, Hannes, Strauss, Christian, Scheller, Christian, Gnanapragassam, Vinayaga S, Horstkorte, Rüdiger

“…Nimodipine is a Ca2+-channel antagonist mainly used for the management of aneurysmal subarachnoid hemorrhage (aSAH) to prevent cerebral vasospasms. However, it…”
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Novel insights in the dysfunction of human blood-brain barrier after glycation by Hussain, Maryam, Bork, Kaya, Gnanapragassam, Vinayaga S., Bennmann, Dorit, Jacobs, Kathleen, Navarette-Santos, Alexander, Hofmann, Britt, Simm, Andreas, Danker, Kerstin, Horstkorte, Rüdiger

“…•We established blood brain barrier model.•Glycation leads to impaired function of the barrier.•Glycation induces a pro-inflammatory response. The blood-brain…”
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Sialic acid metabolic engineering: a potential strategy for the neuroblastoma therapy by Gnanapragassam, Vinayaga S, Bork, Kaya, Galuska, Christina E, Galuska, Sebastian P, Glanz, Dagobert, Nagasundaram, Manimozhi, Bache, Matthias, Vordermark, Dirk, Kohla, Guido, Kannicht, Christoph, Schauer, Roland, Horstkorte, Rüdiger

“…Sialic acids (Sia) represent negative-charged terminal sugars on most glycoproteins and glycolipids on the cell surface of vertebrates. Aberrant expression of…”
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Advanced glycation endproducts interfere with adhesion and neurite outgrowth by Bennmann, Dorit, Horstkorte, Rüdiger, Hofmann, Britt, Jacobs, Kathleen, Navarrete-Santos, Alexander, Simm, Andreas, Bork, Kaya, Gnanapragassam, Vinayaga S

“…Advanced glycation endproducts (AGEs) represent a non-enzymatic posttranslational protein modification. AGEs are generated by a series of chemical reactions of…”
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Mutation of a putative MAP kinase consensus site regulates NCAM endocytosis and NCAM-dependent neurite outgrowth by Goschzik, Tobias, Cremer, Harold, Gnanapragassam, Vinayaga S., Horstkorte, Rüdiger, Bork, Kaya, Diestel, Simone

“…•NCAM140 is phosphorylated by ERK2.•Endocytosis of NCAM140 is regulated by MAP kinase activity.•T803D mutation regulates endocytosis and NCAM-dependent neurite…”
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Correction: Sialic Acid Metabolic Engineering: A Potential Strategy for the Neuroblastoma Therapy by Gnanapragassam, Vinayaga S, Bork, Kaya, Galuska, Christina E, Galuska, Sebastian P, Glanz, Dagobert, Nagasundaram, Manimozhi, Bache, Matthias, Vordermark, Dirk, Kohla, Guido, Kannicht, Christoph, Schauer, Roland, Horstkorte, Rüdiger

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Ascorbic acid leads to glycation and interferes with neurite outgrowth by Scheffler, Jonas, Bork, Kaya, Bezold, Veronika, Rosenstock, Philip, Gnanapragassam, Vinayaga S., Horstkorte, Rüdiger

“…Ascorbic acid better known as vitamin C, is a reducing carbohydrate needed for a variety of functions in the human body. The most important characteristic of…”
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Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice by Klaus, Christine, Hansen, Jan N., Ginolhac, Aurélien, Gérard, Deborah, Gnanapragassam, Vinayaga S., Horstkorte, Rüdiger, Rossdam, Charlotte, Buettner, Falk F.R., Sauter, Thomas, Sinkkonen, Lasse, Neumann, Harald, Linnartz-Gerlach, Bettina

“…Sialic acid-binding Ig-like lectin (Siglec) receptors are linked to neurodegenerative processes, but the role of sialic acids in physiological aging is still…”
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Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains by Simon, Frieder, Bork, Kaya, Gnanapragassam, Vinayaga S, Baldensperger, Tim, Glomb, Marcus A, Di Sanzo, Simone, Ori, Alessandro, Horstkorte, Rüdiger

“…Aging represents the accumulation of changes in an individual over time, encompassing physical, psychological, and social changes. Posttranslational…”
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The expression of sialyltransferases is regulated by the bioavailability and biosynthesis of sialic acids by Bork, Kaya, Weidemann, Wenke, Berneck, Beatrice, Kuchta, Magdalena, Bennmann, Dorit, Thate, Annett, Huber, Otmar, Gnanapragassam, Vinayaga S., Horstkorte, Rüdiger

“…Glycosylation is the most frequent and important post-translational modification of proteins. It occurs on specific consensus sequences but the final structure…”
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Novel Interaction of MUC4 and Galectin: Potential Pathobiological Implications for Metastasis in Lethal Pancreatic Cancer by SENAPATI, Shantibhusan, CHATURVEDI, Pallavi, CHANEY, William G, CHAKRABORTY, Subhankar, GNANAPRAGASSAM, Vinayaga S, SASSON, Aaron R, BATRA, Surinder K

“…Several studies have reported aberrant expression of MUC4 in pancreatic cancer (PC), which is associated with tumorigenicity and metastasis. Mechanisms through…”
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Fluorescent Mimetics of CMP-Neu5Ac Are Highly Potent, Cell-Permeable Polarization Probes of Eukaryotic and Bacterial Sialyltransferases and Inhibit Cellular Sialylation by Preidl, Johannes J., Gnanapragassam, Vinayaga S., Lisurek, Michael, Saupe, Jörn, Horstkorte, Rüdiger, Rademann, Jörg

“…Oligosaccharides of the glycolipids and glycoproteins at the outer membranes of human cells carry terminal neuraminic acids, which are responsible for…”
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Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family by Volkers, Gesa, Lizak, Christian, Niesser, Jürgen, Rosell, Frederico I, Preidl, Johannes, Gnanapragassam, Vinayaga S, Horstkorte, Ruediger, Rademann, Jörg, Strynadka, Natalie C. J

“…Polysialyltransferases synthesize polysialic acid on cell surface-expressed glycoconjugates, which is crucial for developing processes and signaling pathways…”
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Analysis of tumor-associated mucin glycotopes by Western transfer methods by Gnanapragassam, Vinayaga S, Jain, Maneesh, Batra, Surinder K

“…In mucins, glycosylation is complex and the most predominant posttranslational modification. Since mucins exhibit differential glycosylation pattern under…”
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Corrigendum: Fluorescent Mimetics of CMP-Neu5Ac Are Highly Potent, Cell-Permeable Polarization Probes of Eukaryotic and Bacterial Sialyltransferases and Inhibit Cellular Sialylation by Preidl, Johannes J., Gnanapragassam, Vinayaga S., Lisurek, Michael, Saupe, Jörn, Horstkorte, Rüdiger, Rademann, Jörg

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Berichtigung: Fluoreszente Mimetika von CMP-Neu5Ac sind hochaffine, zellgängige Polarisationssonden eukaryotischer und bakterieller Sialyltransferasen und inhibieren die zelluläre Sialylierung by Preidl, Johannes J., Gnanapragassam, Vinayaga S., Lisurek, Michael, Saupe, Jörn, Horstkorte, Rüdiger, Rademann, Jörg

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Fluoreszente Mimetika von CMP-Neu5Ac sind hochaffine, zellgängige Polarisationssonden eukaryotischer und bakterieller Sialyltransferasen und inhibieren die zelluläre Sialylierung by Preidl, Johannes J., Gnanapragassam, Vinayaga S., Lisurek, Michael, Saupe, Jörn, Horstkorte, Rüdiger, Rademann, Jörg

“…Oligosaccharide der Glycolipide und Glycoproteine auf der äußeren Membran humaner Zellen tragen terminale Neuraminsäuren, die für die Zell‐Zell‐Erkennung und…”
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Berichtigung: Fluoreszente Mimetika von CMP‐Neu5Ac sind hochaffine, zellgängige Polarisationssonden eukaryotischer und bakterieller Sialyltransferasen und inhibieren die zelluläre Sialylierung by Preidl, Johannes J., Gnanapragassam, Vinayaga S., Lisurek, Michael, Saupe, Jörn, Horstkorte, Rüdiger, Rademann, Jörg

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Fluoreszente Mimetika von CMP‐Neu5Ac sind hochaffine, zellgängige Polarisationssonden eukaryotischer und bakterieller Sialyltransferasen und inhibieren die zelluläre Sialylierung by Preidl, Johannes J., Gnanapragassam, Vinayaga S., Lisurek, Michael, Saupe, Jörn, Horstkorte, Rüdiger, Rademann, Jörg

“…Oligosaccharide der Glycolipide und Glycoproteine auf der äußeren Membran humaner Zellen tragen terminale Neuraminsäuren, die für die Zell‐Zell‐Erkennung und…”
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