Search Results - "Gnörich, Johannes"

Astroglial glucose uptake determines brain FDG-PET alterations and metabolic connectivity during healthy aging in mice by Bartos, Laura M., Kunte, Sebastian T., Wagner, Stephan, Beumers, Philipp, Schaefer, Rebecca, Zatcepin, Artem, Li, Yunlei, Griessl, Maria, Hoermann, Leonie, Wind-Mark, Karin, Bartenstein, Peter, Tahirovic, Sabina, Ziegler, Sibylle, Brendel, Matthias, Gnörich, Johannes

“…•Cellular sources of FDG-PET signals were evaluated during aging in healthy mice.•Neuronal glucose uptake peaks at 12 months, then declines.•Astroglial glucose…”
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Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy by Ruch, François, Gnörich, Johannes, Wind, Karin, Köhler, Mara, Zatcepin, Artem, Wiedemann, Thomas, Gildehaus, Franz-Joseph, Lindner, Simon, Boening, Guido, von Ungern-Sternberg, Barbara, Beyer, Leonie, Herms, Jochen, Bartenstein, Peter, Brendel, Matthias, Eckenweber, Florian

“…Among functional imaging methods, metabolic connectivity (MC) is increasingly used for investigation of regional network changes to examine the pathophysiology…”
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Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison by Gnörich, Johannes, Koehler, Mara, Wind-Mark, Karin, Klaus, Carolin, Zatcepin, Artem, Palumbo, Giovanna, Lalia, Manvir, Monasor, Laura Sebastian, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Herms, Jochen, Tahirovic, Sabina, Franzmeier, Nicolai, Ziegler, Sibylle, Brendel, Matthias

“…•Three distinct small animal PET scanners show high agreement in Aβ-PET quantification, crucial for multicentric AD research.•Variability in scanner…”
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Depletion and activation of microglia impact metabolic connectivity of the mouse brain by Gnörich, Johannes, Reifschneider, Anika, Wind, Karin, Zatcepin, Artem, Kunte, Sebastian T, Beumers, Philipp, Bartos, Laura M, Wiedemann, Thomas, Grosch, Maximilian, Xiang, Xianyuan, Fard, Maryam K, Ruch, Francois, Werner, Georg, Koehler, Mara, Slemann, Luna, Hummel, Selina, Briel, Nils, Blume, Tanja, Shi, Yuan, Biechele, Gloria, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Bartenstein, Peter, Albert, Nathalie L, Herms, Jochen, Tahirovic, Sabina, Haass, Christian, Capell, Anja, Ziegler, Sibylle, Brendel, Matthias

“…We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine…”
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Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging by Vogler, Letizia, Ballweg, Anna, Bohr, Bernd, Briel, Nils, Wind, Karin, Antons, Melissa, Kunze, Lea H., Gnörich, Johannes, Lindner, Simon, Gildehaus, Franz-Josef, Baumann, Karlheinz, Bartenstein, Peter, Boening, Guido, Ziegler, Sibylle I., Levin, Johannes, Zwergal, Andreas, Höglinger, Günter U., Herms, Jochen, Brendel, Matthias

“…•[18F]UCB-H was evaluated as a preclinical biomarker of synapse density in Alzheimer’s disease (AD) models.•Decreased PET signals reflected synapse loss in…”
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Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice by Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja

“…Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar…”
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A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models by van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I., Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E., Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M., Beumers, Philipp, Capell, Anja, Davis, Sonnet S., de Weerd, Lis, Dugas, Jason C., Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T., Kunze, Lea H., Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O., Nguyen, Hoang N., Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H., Thorne, Robert G., Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y. Joy Yu, Diaz, Dolo, Dennis, Mark S., Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J., Haass, Christian, Lewcock, Joseph W., Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E., Monroe, Kathryn M.

“…Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor…”
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Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency by Reifschneider, Anika, Robinson, Sophie, van Lengerich, Bettina, Gnörich, Johannes, Logan, Todd, Heindl, Steffanie, Vogt, Miriam A, Weidinger, Endy, Riedl, Lina, Wind, Karin, Zatcepin, Artem, Pesämaa, Ida, Haberl, Sophie, Nuscher, Brigitte, Kleinberger, Gernot, Klimmt, Julien, Götzl, Julia K, Liesz, Arthur, Bürger, Katharina, Brendel, Matthias, Levin, Johannes, Diehl‐Schmid, Janine, Suh, Jung, Di Paolo, Gilbert, Lewcock, Joseph W, Monroe, Kathryn M, Paquet, Dominik, Capell, Anja, Haass, Christian

“…Haploinsufficiency of the progranulin (PGRN)‐encoding gene ( GRN ) causes frontotemporal lobar degeneration ( GRN ‐FTLD) and results in microglial…”
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Assessment of 18FPI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function by Meindl, Maria, Zatcepin, Artem, Gnörich, Johannes, Scheifele, Maximilian, Zaganjori, Mirlind, Groß, Mattes, Lindner, Simon, Schaefer, Rebecca, Simmet, Marcel, Roemer, Sebastian, Katzdobler, Sabrina, Levin, Johannes, Höglinger, Günter, Bischof, Ann-Cathrin, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Saller, Thomas, Franzmeier, Nicolai, Ziegler, Sibylle, Brendel, Matthias

“…[18F]PI-2620 positron emission tomography (PET) detects misfolded tau in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). We questioned the…”
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Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function by Meindl, Maria, Zatcepin, Artem, Gnörich, Johannes, Scheifele, Maximilian, Zaganjori, Mirlind, Groß, Mattes, Lindner, Simon, Schaefer, Rebecca, Simmet, Marcel, Roemer, Sebastian, Katzdobler, Sabrina, Levin, Johannes, Höglinger, Günter, Bischof, Ann-Cathrin, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Saller, Thomas, Franzmeier, Nicolai, Ziegler, Sibylle, Brendel, Matthias

“…Purpose [ 18 F]PI-2620 positron emission tomography (PET) detects misfolded tau in progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD). We…”
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Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies by Finze, Anika, Biechele, Gloria, Rauchmann, Boris-Stephan, Franzmeier, Nicolai, Palleis, Carla, Katzdobler, Sabrina, Weidinger, Endy, Guersel, Selim, Schuster, Sebastian, Harris, Stefanie, Schmitt, Julia, Beyer, Leonie, Gnörich, Johannes, Lindner, Simon, Albert, Nathalie L., Wetzel, Christian H., Rupprecht, Rainer, Rominger, Axel, Danek, Adrian, Burow, Lena, Kurz, Carolin, Tato, Maia, Utecht, Julia, Papazov, Boris, Zaganjori, Mirlind, Trappmann, Lena-Katharina, Goldhardt, Oliver, Grimmer, Timo, Haeckert, Jan, Janowitz, Daniel, Buerger, Katharina, Keeser, Daniel, Stoecklein, Sophia, Dietrich, Olaf, Morenas-Rodriguez, Estrella, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Simons, Mikael, Haass, Christian, Höglinger, Günter U., Levin, Johannes, Perneczky, Robert, Brendel, Matthias

“…β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer’s disease (AD), and biomarkers for these…”
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Association of Neurofilament Light Chain, [ 18 F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS by Palleis, Carla, Franzmeier, Nicolai, Weidinger, Endy, Bernhardt, Alexander M, Katzdobler, Sabrina, Wall, Stephan, Ferschmann, Christian, Harris, Stefanie, Schmitt, Julia, Schuster, Sebastian, Gnörich, Johannes, Finze, Anika, Biechele, Gloria, Lindner, Simon, Albert, Nathalie L, Bartenstein, Peter, Sabri, Osama, Barthel, Henryk, Rupprecht, Rainer, Nuscher, Brigitte, Stephens, Andrew W, Rauchmann, Boris-Stephan, Perneczky, Robert, Haass, Christian, Brendel, Matthias, Levin, Johannes, Höglinger, Günter U

“…Corticobasal syndrome (CBS) with underlying 4-repeat tauopathy is a progressive neurodegenerative disease characterized by declining cognitive and motor…”
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Neuroinflammation Parallels 18F‐PI‐2620 Positron Emission Tomography Patterns in Primary 4‐Repeat Tauopathies by Malpetti, Maura, Roemer, Sebastian N., Harris, Stefanie, Gross, Mattes, Gnörich, Johannes, Stephens, Andrew, Dewenter, Anna, Steward, Anna, Biel, Davina, Dehsarvi, Amir, Wagner, Fabian, Müller, Andre, Koglin, Norman, Weidinger, Endy, Palleis, Carla, Katzdobler, Sabrina, Rupprecht, Rainer, Perneczky, Robert, Rauchmann, Boris‐Stephan, Levin, Johannes, Höglinger, Günter U., Brendel, Matthias, Franzmeier, Nicolai

“…Background Preclinical, postmortem, and positron emission tomography (PET) imaging studies have pointed to neuroinflammation as a key pathophysiological…”
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Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice by Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja

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Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies by Roemer, Sebastian N, Brendel, Matthias, Gnoerich, Johannes, Malpetti, Maura, Zaganjori, Mirlind, Quattrone, Andrea, Gross, Mattes, Steward, Anna, Dewenter, Anna, Wagner, Fabian, Dehsarvi, Amir, Ferschmann, Christian, Wall, Stephan, Palleis, Carla, Rauchmann, Boris S, Katzdobler, Sabrina, Jaeck, Alexander, Stockbauer, Anna, Fietzek, Urban M, Bernhardt, Alexander M, Weidinger, Endy, Zwergal, Andreas, Stoecklein, Sophia, Perneczky, Robert, Barthel, Henryk, Sabri, Osama, Levin, Johannes, Hoeglinger, Guenter U, Franzmeier, Nicolai

“…4-repeat (4R) tauopathies are neurodegenerative diseases characterized by cerebral accumulation of 4R tau pathology. The most prominent 4R-tauopathies are…”
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Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies by Ferschmann, Christian, Messerschmidt, Konstantin, Gnörich, Johannes, Barthel, Henryk, Marek, Ken, Palleis, Carla, Katzdobler, Sabrina, Stockbauer, Anna, Fietzek, Urban, Finze, Anika, Biechele, Gloria, Rumpf, Jost-Julian, Saur, Dorothee, Schroeter, Matthias L., Rullmann, Michael, Beyer, Leonie, Eckenweber, Florian, Wall, Stephan, Schildan, Andreas, Patt, Marianne, Stephens, Andrew, Classen, Joseph, Bartenstein, Peter, Seibyl, John, Franzmeier, Nicolai, Levin, Johannes, Höglinger, Günter U., Sabri, Osama, Brendel, Matthias, Scheifele, Maximilian

“…Purpose We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe…”
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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia by Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H, Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E, DeVos, Sarah L, Earr, Timothy K, Lin, Chia-Ching, Davis, Sonnet, Ha, Connie, Leung, Amy Wing-Sze, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Lopez, Isabel, Solanoy, Hilda, Masoud, Shababa T, Liang, Chun-Chi, Lin, Karin, Astarita, Giuseppe, Khoury, Nathalie, Zuchero, Joy Yu, Thorne, Robert G, Shen, Kevin, Miller, Stephanie, Palop, Jorge J, Garceau, Dylan, Sasner, Michael, Whitesell, Jennifer D, Harris, Julie A, Hummel, Selina, Gnörich, Johannes, Wind, Karin, Kunze, Lea, Zatcepin, Artem, Brendel, Matthias, Willem, Michael, Haass, Christian, Barnett, Daniel, Zimmer, Till S, Orr, Anna G, Scearce-Levie, Kimberly, Lewcock, Joseph W, Di Paolo, Gilbert, Sanchez, Pascal E

“…Genetic mutations underlying familial Alzheimer's disease (AD) were identified decades ago, but the field is still in search of transformative therapies for…”
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Combining cerebrospinal fluid and PI‐2620 tau‐PET for biomarker‐based stratification of Alzheimer's disease and 4R‐tauopathies by Dilcher, Roxane, Wall, Stephan, Groß, Mattes, Katzdobler, Sabrina, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Fietzek, Urban, Bernhardt, Alexander, Kurz, Carolin, Ferschmann, Christian, Scheifele, Maximilian, Zaganjori, Mirlind, Gnörich, Johannes, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris‐Stephan, Stöcklein, Sophia, Bartenstein, Peter, Villemagne, Victor, Seibyl, John, Sabri, Osama, Barthel, Henryk, Perneczky, Robert, Schöberl, Florian, Zwergal, Andreas, Höglinger, Günter U., Levin, Johannes, Franzmeier, Nicolai, Brendel, Matthias

“…INTRODUCTION Recent advances in biomarker research have improved the diagnosis and monitoring of Alzheimer's disease (AD), but in vivo biomarker‐based…”
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Biomarker interplay between CSF p‐tau and 18 F‐PI‐2620 PET in Alzheimer’s disease and 4R‐tauopathy by Dilcher, Roxane, Wall, Stephan, Franzmeier, Nicolai, Katzdobler, Sabrina, Barthel, Henryk, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Fietzek, Urban, Kurz, Carolin Isabella, Ferschmann, Chrsitian, Scheifele, Maximilian, Eckenweber, Florian, Zaganjori, Mirlind, Gnörich, Johannes, Danek, Adrian, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris‐Stephan, Stöcklein, Sophia, Perneczky, Robert, Schoeberl, Florian, Zwergal, Andreas, Höglinger, Günter, Bartenstein, Peter, Villemagne, Victor L, Seibyl, John, Sabri, Osama, Levin, Johannes, Brendel, Matthias

“…Abstract Background Reliable biomarkers for detecting different abnormal tau protein isoforms between neurodegenerative diseases are currently missing…”
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Biomarker interplay between CSF p‐tau and 18F‐PI‐2620 PET in Alzheimer’s disease and 4R‐tauopathy by Dilcher, Roxane, Wall, Stephan, Franzmeier, Nicolai, Katzdobler, Sabrina, Barthel, Henryk, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy, Fietzek, Urban, Kurz, Carolin Isabella, Ferschmann, Chrsitian, Scheifele, Maximilian, Eckenweber, Florian, Zaganjori, Mirlind, Gnörich, Johannes, Danek, Adrian, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris‐Stephan, Stöcklein, Sophia, Perneczky, Robert, Schoeberl, Florian, Zwergal, Andreas, Höglinger, Günter, Bartenstein, Peter, Villemagne, Victor L, Seibyl, John, Sabri, Osama, Levin, Johannes, Brendel, Matthias

“…Background Reliable biomarkers for detecting different abnormal tau protein isoforms between neurodegenerative diseases are currently missing. Phosphorylated…”
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