Search Results - "Gmiro, V. E"

Dication Molecules as Tools for Studying Actylcholine and Glutamate Receptors (Review) by Gmiro, V. E.

“…The review covers the pharmacochemical study of two receptor types, the neuronal nicotinate receptor and the glutamate receptor. The structure(activity…”
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Determinants of trapping block of N‐methyl‐d‐aspartate receptor channels by Bolshakov, K. V., Gmiro, V. E., Tikhonov, D. B., Magazanik, L. G.

“…Open channel blockers of NMDA receptors interact with the channel gate in different ways. Compounds like MK‐801 and phencyclidine exhibit pronounced trapping…”
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IEM-1460 and Spermine Potentiate the Analgesic Actions of Fentanyl and Analgin in Rats by Serdyuk, S. E., Gmiro, V. E.

“…Intramuscular administration of the minimum effective doses (MED) of the central analgesics fentanyl and Analgin [translator’s note: metamizole], the NMDA…”
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Search for Selective Glua1 Ampa Receptor Antagonists in a Series of Dicationic Compounds by Gmiro, V. E., Zhigulin, A. S.

“…Homologous series of dicationic derivatives based on adamantyl and phenylcyclohexyl fragments in which the cationic groups and the distance between them were…”
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Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives by Magazanik, L. G., Buldakova, S. L., Samoilova, M. V., Gmiro, V. E., Mellor, I. R., Usherwood, P. N. R.

“…1. The effects of two adamantane derivatives, 1-trimethylammonio-5-(1-adamantane-methyl-ammoniopentane dibromide) (IEM-1460) and…”
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Comparison of the Pharmacological Activity and Safety of 1-Adamantylguanidine and 3,5-Dimethyl-1-Adamantylguanidine to those of Memantine by Gmiro, V. E., Serdyuk, S. E.

“…Guanidine-containing analogs of amantadine and memantine, including 1-adamantylguanidine hydrochloride (IEM-2151) and 3,5-dimethyl-1-adamantylguanidine…”
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Design of antagonists for NMDA and AMPA receptors by Bolshakov, K.V., Kim, K.H., Potapjeva, N.N., Gmiro, V.E., Tikhonov, D.B., Usherwood, P.N.R., Mellor, I.R., Magazanik, L.G.

“…Determinants of antagonism of NMDA and calcium permeable AMPA receptor channels by organic cations were studied using several homologous series of mono- and…”
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Different arrangement of hydrophobic and nucleophilic components of channel binding sites in N-methyl- d-aspartate and AMPA receptors of rat brain is revealed by channel blockade by Bolshakov, K.V, Tikhonov, D.B, Gmiro, V.E, Magazanik, L.G

“…In order to investigate the topography of the channel binding site in (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and N-methyl- d-aspartate…”
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Synthesis and Anxiolytic Activity of 9-(4-Ethylpiperazino-1-Carbonyl)Fluoren-9-OL Hydrochloride, A Structural Analog of the M-Choline Blocker Amizil by Khnychenko, L. K., Yakovleva, E. E., Gmiro, V. E., Shabanov, P. D.

“…Experiments on rats in a depressive-like state model caused by reserpine employed the elevated plus-maze and open-field tests and showed that…”
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Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice by Gmiro, V. E, Serdyuk, S. E, Efremov, O. M

“…Peripheral administration of nicotinic receptor antagonists with a quaternary ammonium group (hexamethonium and chlorisondamine) did not prevent the…”
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Comparison of the Antiparkinson Activity of Levodopa, Memantine, and Guanidine-Containing Analogs of Amantadine and Memantine (IEM-2151 and IEM-2163) in Rats with Rotenone-Induced Parkinsonism by Gmiro, V. E., Serdyuk, S. E., Veselkina, O. S.

“…Rotenone-induced parkinsonism in rats is a widely used animal model of parkinsonism for studies of the antiparkinsonism activity of new substances. The…”
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Comparison of the Chronic Anticonvulsant Activity and Safety of IEM-1913, Sodium Valproate, IEM-1676, and Memantine in Experiments on Rats by Gmiro, V. E., Serdyuk, S. E., Veselkina, O. S.

“…Chronic oral administration of the selective AMPA receptor blocker IEM-1676 and the combined NMDA and AMPA receptor blocker IEM-1913 decreased the severity of…”
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Synthesis and Pharmacological Properties of Adamantane-Containing Bis-Cationic Compounds by Gmiro, V. E., Serdyuk, S. E., Veselkina, O. S.

“…The bis-cationic compound 1-amino-4-(1-adamantanamino)butane dihydrochloride (IEM-1913) has important advantages over clinically employed monocationic…”
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Comparison of the Chronic Anticonvulsant Activity and Safety of IEM-2062, Sodium Valproate, and Memantine in a Corasol Kindling Model in Rats by Gmiro, V. E., Serdyuk, S. E., Veselkina, O. S.

“…Chronic oral administration of IEM-2062 [1-(6-aminohexylamino)-1-phenylcyclohexyl dihydrochloride], which produces combined blockade of NMDA and AMPA…”
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Epinephrine potentiates the analgesic and antidepressant effects of polyvinylpyrrolidone and cholecystokinin due to stimulation of afferents in the gastric mucosa by Serdyuk, S E, Gmiro, V E

“…Treatment with epinephrine, polyvinylpyrrolidone, and cholecystokinin in the minimum effective doses produced maximum analgesic and antidepressant effects and…”
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Mesaton (phenylephrine) Potentiates the Antidepressant and Eliminates the Sedative Action of Amitriptyline in Rats by Serdyuk, S. E., Gmiro, V. E.

“…Single i.m. doses of amitriptyline (10–30 mg/kg) induced a mild antidepressant effect in rats, decreasing immobility in the Porsolt test by factors of no more…”
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Ion channels of glutamate receptors of nerve-muscle junction of larva of the fly Calliphora vicina demonstrate a high structural homology with vertebrate AMPA-channels by Fedorova, I. M, Gmiro, V. E, Magazanik, L. G, Tikhonov, D. B

“…In experiments on the nerve-muscle junction of larvae of the fly Calliphora vicina, regularities of the blocking action of organic cations on ion channels of…”
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Phenylephrine Potentiates the Anticonvulsant Effect and Neutralizes the Sedative Effect of Diazepam in Rats upon Combined Intragastric Administration by Serdyuk, S. E., Gmiro, V. E.

“…High doses of phenylephrine and diazepam (1 and 10 mg/kg, respectively) suppressed the development of generalized tonic-clonic pentylenetetrazole-induced…”
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Voltage‐dependent block of native AMPA receptor channels by dicationic compounds by Tikhonov, D B, Samoilova, M V, Buldakova, S L, Gmiro, V E, Magazanik, L G

“…The kinetics of open channel block of GluR2‐containing and GluR2‐lacking AMPA receptors (AMPAR) by dicationic compounds (IEM‐1460, IEM‐1754, and IEM‐1925) have…”
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Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine by Gmiro, V. E., Serdyuk, S. E., Veselkina, O. S.

“…Adamantane-containing glutamate blocker IEM-1913 (1-amino-4-(1-adamantane-amino)-butane dihydrochloride) equals to memantine in antiparkinsonian potency, but…”
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