Search Results - "Gluzman, Y"

Plasmodium falciparum Ensures Its Amino Acid Supply with Multiple Acquisition Pathways and Redundant Proteolytic Enzyme Systems by Liu, Jun, Istvan, Eva S., Gluzman, Ilya Y., Gross, Julia, Goldberg, Daniel E.

“…Degradation of host hemoglobin by the human malaria parasite Plasmodium falciparum is a massive metabolic process. What role this degradation plays and whether…”
Get full text

The Role of Plasmodium falciparum Food Vacuole Plasmepsins by Liu, Jun, Gluzman, Ilya Y., Drew, Mark E., Goldberg, Daniel E.

“…Plasmepsins (PMs) are thought to have an important function in hemoglobin degradation in the malarial parasite Plasmodium falciparum and have generated…”
Get full text

Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins by Sullivan, David J., Gluzman, Llya Y., Goldberg, Daniel E.

“…The digestive vacuole of Plasmodium falciparum is the site of hemoglobin degradation, heme polymerization into crystalline hemozoin, and antimalarial drug…”
Get full text

On the Molecular Mechanism of Chloroquine's Antimalarial Action by Sullivan, David J., Gluzman, Ilya Y., Russell, David G., Goldberg, Daniel E.

“…Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the…”
Get full text

Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II by Haque, Tasir S, Skillman, A. Geoffrey, Lee, Christina E, Habashita, Hiromu, Gluzman, Ilya Y, Ewing, Todd J. A, Goldberg, Daniel E, Kuntz, Irwin D, Ellman, Jonathan A

“…A number of single-digit nanomolar, low-molecular-weight plasmepsin II aspartyl protease inhibitors have been identified using combinatorial chemistry and…”
Get full text

Changes in the Plasmodial Surface Anion Channel Reduce Leupeptin Uptake and Can Confer Drug Resistance in Plasmodium falciparum-Infected Erythrocytes by Lisk, Godfrey, Pain, Margaret, Gluzman, Ilya Y, Kambhampati, Shivkumar, Furuya, Tetsuya, Su, Xin-Zhuan, Fay, Michael P, Goldberg, Daniel E, Desai, Sanjay A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function by Mohr, I., Gluzman, Y.

“…Novel suppressor variants of conditionally lethal HSV‐1 gamma34.5 deletion mutants have been isolated which exhibit restored ability to grow on neoplastic…”
Get full text

Co‐ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis by Mamoun, Choukri Ben, Gluzman, Ilya Y., Hott, Christian, MacMillan, Sandra K., Amarakone, Aloka S., Anderson, Dustin L., Carlton, Jane M.‐R., Dame, John B., Chakrabarti, Debopam, Martin, Rodger K., Brownstein, Bernard H., Goldberg, Daniel E.

“…Plasmodium falciparum is a protozoan parasite responsible for the most severe forms of human malaria. All the clinical symptoms and pathological changes seen…”
Get full text

A Set of Independent Selectable Markers for Transfection of the Human Malaria Parasite Plasmodium falciparum by Ben Mamoun, Choukri, Gluzman, Ilya Y., Goyard, Sophie, Beverley, Stephen M., Goldberg, Daniel E.

“…Genomic information is rapidly accumulating for the human malaria pathogen, Plasmodium falciparum. Our ability to perform genetic manipulations to understand…”
Get full text

Structure and Inhibition of Plasmepsin II, a Hemoglobin-Degrading Enzyme from Plasmodium falciparum by Silva, A. M., Lee, A. Y., Gulnik, S. V., Majer, P., Collins, J., Bhat, T. N., Collins, P. J., Cachau, R. E., Luker, K. E., Gluzman, I. Y., Francis, S. E., Oksman, A., Goldberg, D. E., Erickson, J. W.

“…Plasmodium falciparum is the major causative agent of malaria, a disease of worldwide importance. Resistance to current drugs such as chloroquine and…”
Get full text

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway by GLUZMAN, I. Y, FRANCIS, S. E, OKSMAN, A, SMITH, C. E, DUFFIN, K. L, GOLDBERG, D. E

“…The human malaria parasite, Plasmodium falciparum, degrades nearly all its host cell hemoglobin during a short segment of its intraerythrocytic development…”
Get full text

Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production by Kolakovich, Kathleen A, Gluzman, Ilya Y, Duffin, Kevin L, Goldberg, Daniel E

“…Intraerythrocytic malaria parasites avidly consume hemoglobin as a source of amino acids for incorporation into parasite proteins. An acidic organelle, the…”
Get full text

Chloroquine resistance not linked to mdr -like genes in a Plasmodium falciparum cross by Wellems, Thomas E, Panton, Lindsey J, Gluzman, Ilya Y, do Rosario, Virgilio E, Gwadz, Robert W, Walker-Jonah, Annie, Krogstad, Donald J

“…Chloroquine is thought to act against falciparum malaria by accumulating in the acid vesicles of the parasite and interfering with their function. Parasites…”
Get full text

Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase by Francis, S.E., Gluzman, I.Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M.L., Sherman, D.R., Russell, D.G., Goldberg, D.E.

“…Intraerythrocytic malaria parasites rapidly degrade virtually all of the host cell hemoglobin. We have cloned the gene for an aspartic hemoglobinase that…”
Get full text

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function by Mohr, I., Gluzman, Y.

Get full text

Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells by STILLMAN, B. W, GLUZMAN, Y

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes by Goldberg, Daniel E., Sharma, Vijay, Oksman, Anna, Gluzman, Ilya Y., Wellems, Thomas E., Piwnica-Worms, David

“…The malaria organism Plasmodium falciparum detoxifies heme released during degradation of host erythrocyte hemoglobin by sequestering it within the parasite…”
Get full text

Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636 by RASMUSSEN, B. A, GLUZMAN, Y, TALLY, F. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D by Carroll, Carolyn DiIanni, Johnson, Theodore O., Tao, Shewei, Lauri, Giorgio, Orlowski, Marc, Gluzman, Ilya Y., Goldberg, Daniel E., Dolle, Roland E.

“…A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P 1′, P 2–P 4…”
Get full text

role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast by Ponpuak, Marisa, Klemba, Michael, Park, Mehea, Gluzman, Ilya Y, Lamppa, Gayle K, Goldberg, Daniel E

“…Falcilysin (FLN) is a zinc metalloprotease thought to degrade globin peptides in the acidic vacuole of the human malaria parasite Plasmodium falciparum. The…”
Get full text