Search Results - "Glushkov, Andrei I."

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff

“…We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the…”
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Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Zilbershtein, Timur M., Migulin, Vasily A., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., McGregor, Malcolm J., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the…”
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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA β-lactams by Pohlmann, Jens, Vasilevich, Natalya I., Glushkov, Andrei I., Kellenberger, Laurenz, Shapiro, Stuart, Caspers, Patrick, Page, Malcolm G.P., Danel, Franck

“…Novel C(3) propenylamide and propenylsulfonamide cephalosporins have been synthesized and tested for their ability to inhibit the penicillin-binding protein 2′…”
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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA b-lactams by Pohlmann, Jens, Vasilevich, Natalya I, Glushkov, Andrei I, Kellenberger, Laurenz, Shapiro, Stuart, Caspers, Patrick, Page, Malcolm GP, Danel, Franck

“…Novel C(3) propenylamide and propenylsulfonamide cephalosporins have been synthesized and tested for their ability to inhibit the penicillin-binding protein 2'…”
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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA β-lactams by POHLMANN, Jens, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, KELLENBERGER, Laurenz, SHAPIRO, Stuart, CASPERS, Patrick, PAGE, Malcolm G. P, DANEL, Franck

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Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, ZILBERSHTEIN, Timur M, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, MIGULIN, Vasily A, VASILEVICH, Natalya I, PARKHILL, Eric Q, GLUSHKOV, Andrei I, MCGREGOR, Malcolm J, BRUNN, Sandra A, CHU, Nancy, JIA HAO

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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, PARKHILL, Eric Q, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, IVANOV, Alexei V, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A, BRUNN, Sandra A

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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, VASILEVICH, Natalya I, BRUNN, Sandra A, CHU, Nancy, JIA HAO, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, PARKHILL, Eric Q, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, MAYBORODA, Elena I, BOZE, Melanie A, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A

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