Search Results - "Glover, Rebecca A."

MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer by Rokhlin, Oskar W, Scheinker, Vladimir S, Taghiyev, Agshin F, Bumcrot, David, Glover, Rebecca A, Cohen, Michael B.

“…We investigated whether knocking down AR expression effects apoptosis after treatment with different apoptosis-inducing agents. We found that siRNA AR (si-AR)…”
Get full text

TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status by Guseva, Natalya V., Rokhlin, Oskar W., Glover, Rebecca A., Cohen, Michael B.

“…A key player in prostate cancer development and progression is the androgen receptor (AR). Tumor-associated lipogenesis can protect cancer cells from…”
Get full text

Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival by Rokhlin, Oskar, Taghiyev, Agshin F., Bayer, K. Ulrich, Bumcrot, David, Kotelianski, Victor E, Glover, Rebecca A., Cohen, Michael B.

“…It has recently been shown that the androgen receptor (AR) is the main factor that required for prostate cancer cells survival. We show that knocking down AR…”
Get full text

P53 and the proteasome regulate androgen receptor activity by Guseva, Natalya V., Rokhlin, Oskar W., Glover, Rebecca A., Cohen, Michael B.

“…Mutual regulation of expression between p53 and AR has been reported. To further investigate the role of p53 in the regulation of AR expression, an…”
Get full text

KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer by Rokhlin, Oskar, Guseva, Natalya V., Taghiyev, Agshin F., Glover, Rebecca A., Cohen, Michael B.

“…It has been suggested that the down-regulation of AR expression should be considered the principal strategy for the treatment of hormone-refractory prostate…”
Get full text

Bisindolylmaleimide IX Facilitates Tumor Necrosis Factor Receptor Family-mediated Cell Death and Acts as an Inhibitor of Transcription by Rokhlin, Oskar W., Glover, Rebecca A., Taghiyev, Agshin F., Guseva, Natalya V., Seftor, Richard E.B., Shyshynova, Inna, Gudkov, Andrei V., Cohen, Michael B.

“…Bisindolylmaleimides (Bis) were originally described as protein kinase C inhibitors. Several studies have shown that Bis potentiate tumor necrosis factor (TNF)…”
Get full text

Generation and Validation of Monoclonal Antibodies Against the Maltose Binding Protein by Park, Yang-Nim, Glover, Rebecca A, Daniels, Karla J, Soll, David R

“…The maltose binding protein (MBP) is a commonly used protein tag. Two monoclonal antibodies (mAbs) were generated against the MBP by immunizing mice with…”
Get more information

Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP by ROKHLIN, Oskar W, TAGHIYEV, Agshin F, GUSEVA, Natalya V, GLOVER, Rebecca A, CHUMAKOV, Peter M, KRAVCHENKO, Julia E, COHEN, Michael B

“…It has been suggested in many studies that combined treatment with chemotherapeutic agents and apoptosis-inducing ligands belonging to TNFR family is a more…”
Get full text

Fas-mediated apoptosis in human prostatic carcinoma cell lines by ROKHLIN, O. W, BISHOP, G. A, HOSTAGER, B. S, WALDSCHMIDT, T. J, SIDORENKO, S. P, PAVLOFF, N, KIEFER, M. C, UMANSKY, S. R, GLOVER, R. A, COHEN, M. B

“…Of six prostatic carcinoma cell lines examined (ALVA31, DU145, JCA1, LNCaP, ND1, and PC3) by flow cytometric analysis, all were found to be positive for Fas…”
Get full text

TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome by Taghiyev, Agshin F, Guseva, Natalya V, Glover, Rebecca A, Rokhlin, Oskar W, Cohen, Michael B

“…The histone deacetylase inhibitor Trichostatin A (TSA) has previously been found to induce caspase activity in the human prostate cancer cell line DU145 and…”
Get full text

Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7 by ROKHLIN, O. W, GLOVER, R. A, COHEN, M. B

“…We previously demonstrated that treatment with cycloheximide (CHX) converted the phenotype of Fas-resistant human prostatic carcinoma cell lines to…”
Get full text

Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP by Rokhlin, Oskar W., Guseva, Natalya V., Tagiyev, Agshin F., Glover, Rebecca A., Cohen, Michael B.

“…BACKGROUND The differential sensitivity of tumor cells to TRAIL‐induced apoptosis may be mediated by different intracellular inhibitors of apoptosis, and only…”
Get full text

p53 is involved in tumor necrosis factor-α-induced apoptosis in the human prostatic carcinoma cell line LNCaP by ROKHLIN, O. W, GUDKOV, A. V, KWEK, S, GLOVER, R. A, GEWIES, A. S, COHEN, M. B

“…The human prostatic carcinoma cell line LNCaP is sensitive to TNF-alpha treatment and expresses wild-type p53. To analyse the possible role of p53 in…”
Get full text

Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines by Rokhlin, Oskar W, Guseva, Natalya V, Taghiyev, Agshin F, Glover, Rebecca A, Cohen, Michael B

“…TPCK is widely used as an inhibitor of chymotrypsin-like proteases but has recently been identified as an inhibitor of the PDK1/Akt pathway. In this study, we…”
Get full text

TRAIL-DISC Formation Is Androgen-Dependent in the Human Prostatic Carcinoma Cell Line LNCaP by Rokhlin, Oskar W, Taghiyev, Agshin F., Guseva, Nataliya V., Glover, Rebecca A., Syrbu, Sergei I., Cohen, Michael B.

“…We and others have previously described that the androgen-responsive human prostatic carcinoma cell line LNCaP is resistant to TRAIL and that TRAIL-mediated…”
Get full text

Multiple effects of N-a-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines by Rokhlin, Oskar W., Guseva, Natalya V., Taghiyev, Agshin F., Glover, Rebecca A., Cohen, Michael B.

“…TPCK is widely used as an inhibitor of chymotrypsin-like proteases but has recently been identified as an inhibitor of the PDK1/Akt pathway. In this study, we…”
Get full text

Caspase-8 activation is necessary but not sufficient fortumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP by ROKHLIN, Oskar W, GUSEVA, Natalya V, TAGIYEV, Agshin F, GLOVER, Rebecca A, COHEN, Michael B

Get full text

TRAIL-DISC Formation Is Androgen-Dependent in the Human Prostatic Carcinoma Cell Line LNCaP by Michael B. Cohen, Oskar W Rokhlin, Rebecca A. Glover, Nataliya V. Guseva, Agshin F. Taghiyev, Sergei I. Syrbu

“…We and others have previously described that the androgen-responsive human prostatic carcinoma cell line LNCaP is resistant to TRAIL and that TRAIL-mediated…”
Get full text

p53 is involved in tumor necrosis factor-[alpha]-induced apoptosis in the human prostatic carcinoma cell line LNCaP by Rokhlin, Oskar W, Gudkov, Andrei V, Kwek, Serena, Glover, Rebecca A, Gewies, Andreas S, Cohen, Michael B

“…The human prostatic carcinoma cell line LNCaP is sensitive to TNF-alpha treatment and expresses wild-type p53. To analyse the possible role of p53 in…”
Get full text

Dominant nature of the resistance to Fas- and tumor necrosis factor-α-mediated apoptosis in human prostatic carcinoma cell lines by ROKHLIN, O. W, HOSTAGER, B. S, BISHOP, G. A, SIDORENKO, S. P, GLOVER, R. A, GUDKOV, A. V, COHEN, M. B

“…We have recently found (O. W. Rokhlin et al., Cancer Res., 57: 1758-1768, 1997) that, although Fas ligation induced apoptosis in two of six human prostatic…”
Get full text