Search Results - "Glossop, Steven C"

Optimization of a Novel Binding Motif to (E)‑3-(3,5-Difluoro-4-((1R,3R)‑2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro‑1H‑pyrido[3,4‑b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist by De Savi, Chris, Bradbury, Robert H, Rabow, Alfred A, Norman, Richard A, de Almeida, Camila, Andrews, David M, Ballard, Peter, Buttar, David, Callis, Rowena J, Currie, Gordon S, Curwen, Jon O, Davies, Chris D, Donald, Craig S, Feron, Lyman J. L, Gingell, Helen, Glossop, Steven C, Hayter, Barry R, Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G, MacFaul, Philip, Moss, Thomas A, Pearson, Stuart E, Tonge, Michael, Walker, Graeme E, Weir, Hazel M, Wilson, Zena

“…The discovery of an orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the…”
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Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase by Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G

“…A novel series of 3-quinoline carboxamides has been discovered and optimized as selective inhibitors of the ataxia telangiectasia mutated (ATM) kinase. From a…”
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Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase by Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G

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A Novel Series of 4-Piperidinopyridine and 4-Piperidinopyrimidine Inhibitors of 2,3-Oxidosqualene Cyclase−Lanosterol Synthase by Brown, George R, Hollinshead, David M, Stokes, Elaine S. E, Waterson, David, Clarke, David S, Foubister, Alan J, Glossop, Steven C, McTaggart, Fergus, Mirrlees, Donald J, Smith, Graham J, Wood, Robin

“…A novel series of 4-piperidinopyridines and 4-piperidinopyrimidines showed potent and selective inhibition of rat 2,3-oxidosqualene cyclase−lanosterol synthase…”
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Quinuclidine Inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase:  Optimization from Lipid Profiles by Brown, George R, Hollinshead, David M, Stokes, Elaine S. E, Clarke, David S, Eakin, M. Allan, Foubister, Alan J, Glossop, Steven C, Griffiths, David, Johnson, Michael C, McTaggart, Fergus, Mirrlees, Donald J, Smith, Graham J, Wood, Robin

“…Novel 3-substituted quinuclidine inhibitors of cholesterol biosynthesis are reported. Compounds were optimized against oxidosqualene cyclase-lanosterol…”
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Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist by De Savi, Chris, Bradbury, Robert H., Rabow, Alfred A., Norman, Richard A., de Almeida, Camila, Andrews, David M., Ballard, Peter, Buttar, David, Callis, Rowena J., Currie, Gordon S., Curwen, Jon O., Davies, Chris D., Donald, Craig S., Feron, Lyman J. L., Gingell, Helen, Glossop, Steven C., Hayter, Barry R., Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G., MacFaul, Philip, Moss, Thomas A., Pearson, Stuart E., Tonge, Michael, Walker, Graeme E., Weir, Hazel M., Wilson, Zena

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