Search Results - "Gloss, Brian S."

The specificity of long noncoding RNA expression by Gloss, Brian S., Dinger, Marcel E.

“…Over the last decade, long noncoding RNAs (lncRNAs) have emerged as a fundamental molecular class whose members play pivotal roles in the regulation of the…”
Get full text

lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs by Quek, Xiu Cheng, Thomson, Daniel W, Maag, Jesper L V, Bartonicek, Nenad, Signal, Bethany, Clark, Michael B, Gloss, Brian S, Dinger, Marcel E

“…Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been examined for biological function…”
Get full text

Realizing the significance of noncoding functionality in clinical genomics by Gloss, Brian S., Dinger, Marcel E.

“…Clinical genomics promises unprecedented precision in understanding the genetic basis of disease. Understanding the impact of variation across the genome is…”
Get full text

Unexpected features of the dark proteome by Perdigão, Nelson, Heinrich, Julian, Stolte, Christian, Sabir, Kenneth S., Buckley, Michael J., Tabor, Bruce, Signal, Beth, Gloss, Brian S., Hammang, Christopher J., Rost, Burkhard, Schafferhans, Andrea, O’Donoghue, Seán I.

“…We surveyed the “dark” proteome–that is, regions of proteins never observed by experimental structure determination and inaccessible to homology modeling. For…”
Get full text

Machine learning annotation of human branchpoints by Signal, Bethany, Gloss, Brian S, Dinger, Marcel E, Mercer, Tim R

“…Abstract Motivation The branchpoint element is required for the first lariat-forming reaction in splicing. However current catalogues of human branchpoints…”
Get full text

A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes by Alharthi, Jawaher, Bayoumi, Ali, Thabet, Khaled, Pan, Ziyan, Gloss, Brian S., Latchoumanin, Olivier, Lundberg, Mischa, Twine, Natalie A., McLeod, Duncan, Alenizi, Shafi, Adams, Leon A., Weltman, Martin, Berg, Thomas, Liddle, Christopher, George, Jacob, Eslam, Mohammed

“…The breakdown of toll-like receptor (TLR) tolerance results in tissue damage, and hyperactivation of the TLRs and subsequent inflammatory consequences have…”
Get full text

WGCNA Identifies Translational and Proteasome-Ubiquitin Dysfunction in Rett Syndrome by Haase, Florencia, Gloss, Brian S., Tam, Patrick P. L., Gold, Wendy A.

“…Rett Syndrome (RTT) is an X linked neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, resulting in severe…”
Get full text

Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage by Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropée, Romain, Patch, Ann-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen, Shu W., Day, Bryan, Möller, Andreas, Cloonan, Nicole, Pearson, John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E., Edwards, Stacey L., French, Juliet D.

“…Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a…”
Get full text

PEMT Mediates Hepatitis C Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication by Abomughaid, Mosleh, Tay, Enoch S E, Pickford, Russell, Malladi, Chandra, Read, Scott A, Coorssen, Jens R, Gloss, Brian S, George, Jacob, Douglas, Mark W

“…The hepatitis C virus (HCV) relies on cellular lipid pathways for virus replication and also induces liver steatosis, but the mechanisms involved are not…”
Get full text

Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome by Alshammery, Sarah, Patel, Shrujna, Jones, Hannah F, Han, Velda X, Gloss, Brian S, Gold, Wendy A, Dale, Russell C

“…Neurodevelopmental disorders (NDDs), including autism-spectrum disorders (ASD) and Tourette syndrome (TS) are common brain conditions which often co-exist, and…”
Get full text

Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer by Montavon, Céline, Gloss, Brian S, Warton, Kristina, Barton, Caroline A, Statham, Aaron L, Scurry, James P, Tabor, Bruce, Nguyen, Tuan V, Qu, Wenja, Samimi, Goli, Hacker, Neville F, Sutherland, Robert L, Clark, Susan J, O'Brien, Philippa M

“…Abstract Objective Altered DNA methylation patterns hold promise as cancer biomarkers. In this study we selected a panel of genes which are commonly methylated…”
Get full text

High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci by Gloss, Brian S., Signal, Bethany, Cheetham, Seth W., Gruhl, Franziska, Kaczorowski, Dominik C., Perkins, Andrew C., Dinger, Marcel E.

“…Cellular responses to stimuli are rapid and continuous and yet the vast majority of investigations of transcriptional responses during developmental…”
Get full text

Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis by Read, Scott A, Gloss, Brian S, Liddle, Christopher, George, Jacob, Ahlenstiel, Golo

“…Interferon lambdas (IFN-λs) are antiviral cytokines that restrict pathogen infection and dissemination at barrier surfaces. Controlled expression of IFN-λs…”
Get full text

Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer by Moran-Jones, Kim, Gloss, Brian S, Murali, Rajmohan, Chang, David K, Colvin, Emily K, Jones, Marc D, Yuen, Samuel, Howell, Viive M, Brown, Laura M, Wong, Carol W, Spong, Suzanne M, Scarlett, Christopher J, Hacker, Neville F, Ghosh, Sue, Mok, Samuel C, Birrer, Michael J, Samimi, Goli

“…Ovarian cancer is the most common cause of death among women with gynecologic cancer. We examined molecular profiles of fibroblasts from normal ovary and…”
Get full text

Computational Approaches for Functional Prediction and Characterisation of Long Noncoding RNAs by Signal, Bethany, Gloss, Brian S, Dinger, Marcel E

“…Although a considerable portion of eukaryotic genomes is transcribed as long noncoding RNAs (lncRNAs), the vast majority are functionally uncharacterised. The…”
Get full text

Epigenetic biomarkers in epithelial ovarian cancer by Gloss, Brian S, Samimi, Goli

“…Abstract Ovarian cancer is the most lethal gynecological malignancy and the 5th leading cause of cancer death in women. Women with ovarian cancer are typically…”
Get full text

MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome by Byrne, Jennifer A, Maleki, Sanaz, Hardy, Jayne R, Gloss, Brian S, Murali, Rajmohan, Scurry, James P, Fanayan, Susan, Emmanuel, Catherine, Hacker, Neville F, Sutherland, Robert L, Defazio, Anna, O'Brien, Philippa M

“…The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus…”
Get full text

Loss of metabolic adaptation in lean MAFLD is driven by endotoxemia leading to epigenetic reprogramming by Alharthi, Jawaher, Pan, Ziyan, Gloss, Brian S., McLeod, Duncan, Weltman, Martin, George, Jacob, Eslam, Mohammed

“…Lean patients with MAFLD have an initial adaptive metabolic response characterised by increased serum bile acids and Farnesoid X Receptor (FXR) activity. How…”
Get full text

Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells by Micklethwaite, Kenneth P., Gowrishankar, Kavitha, Gloss, Brian S., Li, Ziduo, Street, Janine A., Moezzi, Leili, Mach, Melanie A., Sutrave, Gaurav, Clancy, Leighton E., Bishop, David C., Louie, Raymond H.Y., Cai, Curtis, Foox, Jonathan, MacKay, Matthew, Sedlazeck, Fritz J., Blombery, Piers, Mason, Christopher E., Luciani, Fabio, Gottlieb, David J., Blyth, Emily

“…We performed a phase 1 clinical trial to evaluate outcomes in patients receiving donor-derived CD19-specific chimeric antigen receptor (CAR) T cells for B-cell…”
Get full text

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells by Bishop, David C., Clancy, Leighton E., Simms, Renee, Burgess, Jane, Mathew, Geetha, Moezzi, Leili, Street, Janine A., Sutrave, Gaurav, Atkins, Elissa, McGuire, Helen M., Gloss, Brian S., Lee, Koon, Jiang, Wei, Maddock, Karen, McCaughan, Georgia, Avdic, Selmir, Antonenas, Vicki, O'Brien, Tracey A., Shaw, Peter J., Irving, David O., Gottlieb, David J., Blyth, Emily, Micklethwaite, Kenneth P.

Get full text