Search Results - "Gloger, Israel S."

Trust in Science: a novel research partnership model in Latin America by Gloger, Israel S., Felice, Rosana, Madauss, Kevin P.

“…Ten years ago, GlaxoSmithKline established an innovative model for public–private research partnerships in Latin America known as Trust in Science. Here, we…”
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Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease by Smith, Andrew M, Rahman, Farooq Z, Hayee, Bu'Hussain, Graham, Simon J, Marks, Daniel J B, Sewell, Gavin W, Palmer, Christine D, Wilde, Jonathan, Foxwell, Brian M J, Gloger, Israel S, Sweeting, Trevor, Marsh, Mark, Walker, Ann P, Bloom, Stuart L, Segal, Anthony W

“…The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these patients possess an impaired acute inflammatory response, which could…”
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ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation by Dow, David J, Huxley-Jones, Julie, Hall, Jamie M, Francks, Clyde, Maycox, Peter R, Kew, James N.C, Gloger, Israel S, Mehta, Nalini A.L, Kelly, Fiona M, Muglia, Pierandrea, Breen, Gerome, Jugurnauth, Sarah, Pederoso, Inti, St.Clair, David, Rujescu, Dan, Barnes, Michael R

“…Abstract We previously reported an association with a putative functional variant in the ADAMTSL3 gene, just below genome-wide significance in a genome-wide…”
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Purification, Properties, Sequencing, and Cloning of a Lipoprotein-Associated, Serine-Dependent Phospholipase Involved in the Oxidative Modification of Low-Density Lipoproteins by Tew, David G, Southan, Christopher, Rice, Simon Q.J, Li, Haodong, Boyd, Helen F, Moores, Kitty, Gloger, Israel S, Macphee, Colin H

“…A novel LDL-associated phospholipase A2 (LDL-PLA2) has been purified to homogeneity from human LDL obtained from plasma apheresis. This enzyme has activity…”
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Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein by Torres, Nicolas, Regge, María Victoria, Secchiari, Florencia, Friedrich, Adrián David, Spallanzani, Raúl Germán, Raffo Iraolagoitia, Ximena Lucía, Núñez, Sol Yanel, Sierra, Jessica Mariel, Ziblat, Andrea, Santilli, María Cecilia, Gilio, Nicolás, Almada, Evangelina, Lauche, Constanza, Pardo, Romina, Domaica, Carolina Inés, Fuertes, Mercedes Beatriz, Madauss, Kevin Patrick, Hance, Kenneth W, Gloger, Israel S, Zylberman, Vanesa, Goldbaum, Fernando Alberto, Zwirner, Norberto Walter

“…BackgroundNatural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor…”
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Molecular Cloning and Functional Characterization of MCH2, a Novel Human MCH Receptor by Hill, Jeffrey, Duckworth, Malcolm, Murdock, Paul, Rennie, Gillian, Sabido-David, Cibele, Ames, Robert S., Szekeres, Philip, Wilson, Shelagh, Bergsma, Derk J., Gloger, Israel S., Levy, Dana S., Chambers, Jon K., Muir, Alison I.

“…Melanin-concentrating hormone (MCH) is involved in the regulation of feeding and energy homeostasis. Recently, a 353-amino acid splice variant form of the…”
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The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone by Akuffo, Emma L., Davis, John B., Fox, Steven M., Gloger, Israel S., Hosford, David, Kinsey, Emma E., Jones, Neil A., Nock, Christina M., Roses, Allen D., Saunders, Ann M., Mark Skehel, J., Smith, Marjorie A., Cutler, Paul

“…Abstract Recent advances in clinical, pathological and neuroscience studies have identified disease-modifying therapeutic approaches for Alzheimer's disease…”
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Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma by Cutler, Paul, Akuffo, Emma L., Bodnar, Wanda M., Briggs, Deborah M., Davis, John B., Debouck, Christine M., Fox, Steven M., Gibson, Rachel A., Gormley, Darren A., Holbrook, Joanna D., Hunter, A. Jacqueline, Kinsey, Emma E., Prinjha, Rabinder, Richardson, Jill C., Roses, Allen D., Smith, Marjorie A., Tsokanas, Nikos, Willé, David R., Wu, Wen, Yates, John W., Gloger, Israel S.

“…Emerging disease modifying therapeutic strategies for Alzheimer's disease (AD) have generated a critical need for biomarkers of early stage disease. Here, we…”
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Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor by Rice, S Q, Southan, C, Boyd, H F, Terrett, J A, MacPhee, C H, Moores, K, Gloger, I S, Tew, D G

“…Using expressed sequence tag (EST) homology screening, a new human serine dependent phospholipase A2 (HSD-PLA2) was identified that has 40% amino acid identity…”
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Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel by Chapman, Conrad G., Meadows, Helen J., Godden, Rob J., Campbell, David A., Duckworth, Malcolm, Kelsell, Rosemary E., Murdock, Paul R., Randall, Andrew D., Rennie, Gillian I., Gloger, Israel S.

“…We have isolated, by degenerate PCR, a complementary DNA encoding a novel two pore domain potassium channel. This is the 7th functional member of the human…”
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Characterisation of gene expression changes following permanent MCAO in the rat using subtractive hybridisation by Bates, Stewart, Read, Simon J., Harrison, David C., Topp, Simon, Morrow, Rachel, Gale, Davina, Murdock, Paul, Barone, Frank C., Parsons, Andrew A., Gloger, Israel S.

“…Failure of several putative neuroprotectants in large multicentred clinical trials has re-focussed attention on the predictability of pre-clinical animal…”
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Probing the function of novel genes in the nervous system: is antisense the answer? by Jackie Hunter, A., Leslie, Ron A., Gloger, Israel S., Lawrence, Mark

“…At an international symposium, some stimulating discussions took place that resulted in some consensus on how antisense probes should be used as…”
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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase by Hussain, Ishrut, Powell, David, Howlett, David R., Tew, David G., Meek, Thomas D., Chapman, Conrad, Gloger, Israel S., Murphy, Kay E., Southan, Christopher D., Ryan, Dominic M., Smith, Trudi S., Simmons, David L., Walsh, Frank S., Dingwall, Colin, Christie, Gary

“…The Alzheimer's disease β-amyloid peptide (Aβ) is produced by excision from the type 1 integral membrane glycoprotein amyloid precursor protein (APP) by the…”
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Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease by Smith, Andrew M., Rahman, Farooq Z., Hayee, Bu'Hussain, Graham, Simon J., Marks, Daniel J.B., Sewell, Gavin W., Palmer, Christine D., Wilde, Jonathan, Foxwell, Brian M.J., Gloger, Israel S., Sweeting, Trevor, Marsh, Mark, Walker, Ann P., Bloom, Stuart L., Segal, Anthony W.

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Systematic screening of the LDL-PLA2 gene for polymorphic variants and case-control analysis in schizophrenia by Bell, R, Collier, D A, Rice, S Q, Roberts, G W, MacPhee, C H, Kerwin, R W, Price, J, Gloger, I S

“…Systematic scans of the genome using microsatellite markers have identified chromosome 6p21.1 as a putative locus for schizophrenia in multiply affected…”
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Systematic Screening of the LDL-PLA2Gene for Polymorphic Variants and Case-Control Analysis in Schizophrenia by Bell, Rachel, Collier, David A., Rice, Simon Q.J., Roberts, Gareth W., MacPhee, Colin H., Kerwin, Robert W., Price, Jack, Gloger, Israel S.

“…Systematic scans of the genome using microsatellite markers have identified chromosome 6p21.1 as a putative locus for schizophrenia in multiply affected…”
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Expression and functional characterisation of a synthetic version of the human D4 dopamine receptor in a stable human cell line by McHale, Mark, Coldwell, Martin C., Herrity, Nicole, Boyfield, Izzy, Winn, Fiona M., Ball, Stuart, Cook, Ted, Robinson, Jeff H., Gloger, Israel S.

“…A synthetic version of the human D4 (hD4) dopamine receptor was prepared. The G/C content of the natural gene was reduced by 14% without altering the amino…”
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Expression and functional characterisation of a synthetic version of the human D 4 dopamine receptor in a stable human cell line by McHale, Mark, Coldwell, Martin C., Herrity, Nicole, Boyfield, Izzy, Winn, Fiona M., Ball, Stuart, Cook, Ted, Robinson, Jeff H., Gloger, Israel S.

“…A synthetic version of the human D 4 (hD4) dopamine receptor was prepared. The G/C content of the natural gene was reduced by 14% without altering the amino…”
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Cloning and expression of a human ATP‐citrate lyase cDNA by ELSHOURBAGY, Nabil A., NEAR, Joseph C., KMETZ, Peter J., WELLS, Timothy N. C., GROOT, Pieter H. E., SAXTY, Barbara A., HUGHES, Stephen A., FRANKLIN, Michelle, GLOGER, Israel S.

“…A full‐length cDNA clone of 4.3 kb encoding the human ATP‐citrate lyase enzyme has been isolated by screening a human cDNA library with the recently isolated…”
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cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family by Cook, E A, Groenewegen, W A, Gloger, I S, Piggott, J R, Suckling, K E, Wolf, C R

“…Liver mRNA from female adult rats which had been maintained on a cholestyramine diet (4% w/w) was used to construct a cDNA-library in lambda gt11. The library…”
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