Search Results - "Glick, GD"

Characterization of the metabolic phenotype of chronically activated lymphocytes by Wahl, DR, Petersen, B., Warner, R., Richardson, BC, Glick, GD, Opipari, AW

“…Activated lymphocytes proliferate, secrete cytokines, and can make antibodies. Normally activated B and T cells meet the bioenergetic demand for these…”
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Targeting the NLRP3 inflammasome in inflammatory diseases by Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke

“…The inflammasome is a key integration point for innate immunity. As such, targeting this signalling hub has the potential to be useful in numerous autoimmune…”
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Dissecting the Behavior of a Promiscuous Solvate Former by Price, Christopher P., Glick, Gary D., Matzger, Adam J.

“…Take any partner: Benzodiazepine derivative Bz‐423 (see picture) can be described as an indiscriminate solvate former as it cocrystallizes with a diverse array…”
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Signaling pathways and effector mechanisms pre-programmed cell death by Blatt, Neal B., Glick, Gary D.

“…Apoptosis is a complex biochemical process that involves all aspects of the cell from the plasma membrane to the nucleus. Apoptosis stimuli are mediated by…”
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The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation by SUNDBERG, Thomas B, NEY, Gina M, SUBRAMANIAN, Chitra, OPIPARI, Anthony W, GLICK, Gary D

“…Myc proteins regulate cell growth and are oncogenic in many cancers. Although these proteins are validated molecular anticancer targets, new therapies aimed at…”
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The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells by BOITANO, Anthony, ELLMAN, Jonathan A, GLICK, Gary D, OPIPARI, Anthony W

“…Bz-423 is a novel proapoptotic 1,4-benzodiazepine that induces cell death via a superoxide signal. Previous work has shown that Bz-423 ameliorates disease in…”
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Anti-DNA autoantibodies and systemic lupus erythematosus by Blatt, Neal B, Glick, Gary D

“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects most of the organs and tissues of the body, causing glomerulonephritis,…”
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Mutational Analysis of a Sequence-Specific ssDNA Binding Lupus Autoantibody by Cleary, Joanne, Glick, Gary D

“…11F8 is a murine anti-ssDNA monoclonal autoantibody isolated from a lupus prone autoimmune mouse. This mAb binds sequence specifically, and prior studies have…”
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Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and x-ray crystallography by Sauter, Nicholas K, Hanson, John E, Glick, Gary D, Brown, Jerry H, Crowther, Robert L, Park, Seong Joon, Skehel, John J, Wiley, Don C

“…The interaction between influenza virus hemagglutinin and its cell-surface receptor, 5-N-acetylneuraminic acid (sialic acid), was probed by the synthesis of 12…”
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Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones by Francis, Tasha M., Sundberg, Thomas B., Cleary, Joanne, Groendyke, Todd, Opipari, Anthony W., Glick, Gary D.

“…A 1,4-benzodiazepine-2,5-dione (BZD) library was evaluated for lymphotoxic members. When the C3 substituent contains an electron-rich heterocycle, the…”
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Thermodynamic Basis for Sequence-Specific Recognition of ssDNA by an Autoantibody by Ackroyd, P. Christine, Cleary, Joanne, Glick, Gary D

“…11F8 is a sequence-specific DNA binding monoclonal autoantibody previously isolated from an autoimmune lupus-prone mouse [Stevens, S. Y., and Glick, G. D…”
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A Novel Benzodiazepine Increases the Sensitivity of B Cells to Receptor Stimulation with Synergistic Effects on Calcium Signaling and Apoptosis by Bednarski, Jeffrey J, Lyssiotis, Costas A, Roush, Rebecca, Boitano, Anthony E, Glick, Gary D, Opipari, Jr, Anthony W

“…Bz-423 is a 1,4-benzodiazepine with selective lymphotoxic properties and potent therapeutic activity against lupus-like disease in autoimmune mice. In NZB/W…”
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Kinetic Analysis of Sequence-Specific Recognition of ssDNA by an Autoantibody by Beckingham, Jennifer A, Cleary, Joanne, Bobeck, Melissa, Glick, Gary D

“…11F8 is a pathogenic monoclonal anti-ssDNA autoantibody isolated from a lupus prone mouse. Previous studies established that 11F8 is sequence-specific and…”
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Conformational Transitions of an Unmodified tRNA:  Implications for RNA Folding by Maglott, Emily J, Deo, Sanmitra S, Przykorska, Anna, Glick, Gary D

“…Unmodified tRNAs are powerful systems to study the effects of posttranscriptional modifications and site-directed mutations on both the structure and function…”
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Design, synthesis, and analysis of conformationally constrained nucleic acids by Glick, Gary D.

“…In this review I discuss straightforward and general methods to modify nucleic acid structure with disulfide cross‐links. A motivating factor in developing…”
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A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin by Varani, James, Bhagavathula, Narasimharao, Nerusu, Kamalakar C, Sherzer, Hilary, Fay, Kevin, Boitano, Anthony E, Glick, Gary D, Johnson, Kent, Kang, Sewon, Opipari, Jr, Anthony W

“…Bz-423 is a new benzodiazepine that has cytotoxic and cytostatic effects against a number of cell types in culture, and recent studies have shown efficacy in…”
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Evidence for Sequence-Specific Recognition of DNA by Anti-Single-Stranded DNA Autoantibodies by Stevens, Shawn Y, Glick, Gary D

“…Anti-DNA autoantibodies are a serological hallmark of the autoimmune disorder systemic lupus erythematosus. In a process involving antigen recognition, these…”
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Structure activity studies of a novel cytotoxic benzodiazepine by Boitano, Anthony, Emal, Cory D, Leonetti, Francesco, Blatt, Neal B, Dineen, Thomas A, Ellman, Jonathan A, Roush, William R, Opipari, Anthony W, Glick, Gary D

“…Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have…”
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Design, Synthesis, and Analysis of Disulfide Cross-Linked DNA Duplexes by Osborne, Scott E, Völker, Jens, Stevens, Shawn Y, Breslauer, Kenneth J, Glick, Gary D

“…The design, synthesis, and analysis of analogs of d(CGCGAATTCGCG)2 possessing one or two intrahelical disulfide cross-links is reported. The cross-linked…”
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Sequence specific recognition of ssDNA by a lupus autoantibody: kinetics and mechanism of binding by Beckingham, Jennifer A., Glick, Gary D.

“…11F8 is a pathogenic anti-ssDNA monoclonal autoantibody isolated from a lupus-prone mouse. Previous studies have established that 11F8 is sequence specific. To…”
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