Search Results - "Glennon, R A"

Abuse-related and abuse-limiting effects of methcathinone and the synthetic “bath salts” cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats by Bonano, J. S., Glennon, R. A., De Felice, L. J., Banks, M. L., Negus, S. S.

“…Rationale Abuse of synthetic cathinones, popularized as “bath salts,” has increased dramatically in the USA since their debut in 2010. Preclinical behavioral…”
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Structural Modification of the Designer Stimulant α‑Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters by Kolanos, R, Sakloth, F, Jain, A. D, Partilla, J. S, Baumann, M. H, Glennon, R. A

“…α-Pyrrolidinovalerophenone (α-PVP, 7) is an illegal synthetic stimulant that is being sold on the clandestine market as “flakka” and “gravel”. The potent…”
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Stereoselective Actions of Methylenedioxypyrovalerone (MDPV) To Inhibit Dopamine and Norepinephrine Transporters and Facilitate Intracranial Self-Stimulation in Rats by Kolanos, R, Partilla, J. S, Baumann, M. H, Hutsell, B. A, Banks, M. L, Negus, S. S, Glennon, R. A

“…The designer stimulant methylenedioxypyrovalerone (MDPV) is a potent reuptake inhibitor at transporters for dopamine (DAT) and norepinephrine (NET) that…”
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Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach by Glennon, R A

“…At least two different types of sigma (sigma1 and sigma2) receptors have been identified. A structural feature common to high-affinity (Ki <10 nM) sigma1…”
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Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice by Damaj, M I, Fei-Yin, M, Dukat, M, Glassco, W, Glennon, R A, Martin, B R

“…The objective of this study was to determine which nicotinic receptor subtypes are involved in antinociception and their site of action. For that, the…”
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Quantitative structure–activity relationship analysis of the pharmacology of para‐substituted methcathinone analogues by Bonano, J S, Banks, M L, Kolanos, R, Sakloth, F, Barnier, M L, Glennon, R A, Cozzi, N V, Partilla, J S, Baumann, M H, Negus, S S

“…Background and Purpose Methcathinone (MCAT) is a potent monoamine releaser and parent compound to emerging drugs of abuse including mephedrone (4‐CH3 MCAT),…”
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Binding of β-carbolines at 5-HT2 serotonin receptors by GRELLA, Brian, TEITLER, Milt, SMITH, Carol, HERRICK-DAVIS, Katharine, GLENNON, R. A

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Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para‐substituted methcathinone analogues by Sakloth, F, Kolanos, R, Mosier, P D, Bonano, J S, Banks, M L, Partilla, J S, Baumann, M H, Negus, S S, Glennon, R A

“…Background and Purpose There is growing concern over the abuse of certain psychostimulant methcathinone (MCAT) analogues. This study extends an initial…”
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Homoazanicotine:  A Structure-Affinity Study for Nicotinic Acetylcholine (nACh) Receptor Binding by Ferretti, G, Dukat, M, Giannella, M, Piergentili, A, Pigini, M, Quaglia, W, Damaj, M. I, Martin, B. R, Glennon, R. A

“…We have recently identified 3-[(1-methyl)-4,5-dihydro-1H-imidazol-2-yl)methyl]pyridine (homoazanicotine, 8) as a novel nicotinic acetylcholinergic (nACh)…”
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Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors by Nelson, D. L., Lucaites, V. L., Wainscott, D. B., Glennon, R. A.

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Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens by TITELER, M, LYON, R. A, GLENNON, R. A

“…Alterations in brain serotonergic function have been implicated in the mechanism of action of LSD, mescaline, and other similarly acting hallucinogenic drugs…”
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Is a nitrogen atom an important pharmacophoric element in sigma ligand binding ? by ABLORDEPPEY, S. Y, FISCHER, J. B, GLENNON, R. A

“…A lingering question in sigma receptor ligand development is whether a nitrogen atom serves as an important pharmacophoric element in binding affinity. To…”
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Central serotonin receptors as targets for drug research by Glennon, Richard A

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Cathinone: An Investigation of Several N-Alkyl and Methylenedioxy-Substituted Analogs by Dal Cason, Terry A, Young, Richard, Glennon, Richard A

“…DAL CASON, T. A., R. YOUNG AND R. A. GLENNON. Cathinone: An investigation of several N -alkyl and methylenedioxy-substituted analogs. PHARMACOL BIOCHEM BEHAV…”
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Lobeline:  Structure−Affinity Investigation of Nicotinic Acetylcholinergic Receptor Binding by Flammia, Dwight, Dukat, Malgorzata, Damaj, M. Imad, Martin, Billy, Glennon, Richard A

“…(−)Lobeline (1) and (−)nicotine (2) bind at neuronal nicotinic cholinergic (nACh) receptors with high affinity (K i = 4 and 2 nM, respectively). Previous…”
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Autoradiographic characterization of (+-)-1-(2,5-dimethoxy-4-[125I] iodophenyl)-2-aminopropane ([125I]DOI) binding to 5-HT2 and 5-HT1c receptors in rat brain by Appel, N M, Mitchell, W M, Garlick, R K, Glennon, R A, Teitler, M, De Souza, E B

“…The 5-HT2 (serotonin) receptor has traditionally been labeled with antagonist radioligands such as [3H]ketanserin and [3H]spiperone, which label both agonist…”
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Behavioral characterization of 2- O-desmethyl and 5- O-desmethyl metabolites of the phenylethylamine hallucinogen DOM by Eckler, J.R., Chang-Fong, J., Rabin, R.A., Smith, C., Teitler, M., Glennon, R.A., Winter, J.C.

“…The present investigation was undertaken to test the hypothesis that known metabolites of the phenylethylamine hallucinogen…”
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Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors by Ferretti, G., Dukat, M., Giannella, M., Piergentili, A., Pigini, M., Quaglia, W., Damaj, M.I., Martin, B.R., Glennon, R.A.

“…A total of 20 substituted analogues of nicotine ( 1a) and homoazanicotine ( 3a) were examined in order to determine whether or not they might bind in a similar…”
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Investigation of hallucinogenic and related β-carbolines by Grella, Brian, Dukat, Malgorzata, Young, Richard, Teitler, Milt, Herrick-Davis, Katharine, Gauthier, Colleen B, Glennon, Richard A

“…Certain β-carbolines are known to be hallucinogenic in humans, and several produce stimulus effects in animals similar to those of the classical hallucinogen…”
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Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding by Choudhary, M S, Sachs, N, Uluer, A, Glennon, R A, Westkaemper, R B, Roth, B L

“…In this paper we show that a highly conserved aromatic residue, phenylalanine at the 340-position, is essential for ergoline binding to 5-hydroxytryptamine2A…”
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