Search Results - "Glennon, Elizabeth K.K."

Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi by Drexler, Anna L, Pietri, Jose E, Pakpour, Nazzy, Hauck, Eric, Wang, Bo, Glennon, Elizabeth K K, Georgis, Martha, Riehle, Michael A, Luckhart, Shirley

“…Insulin and insulin-like growth factor signaling (IIS) regulates cell death, repair, autophagy, and renewal in response to stress, damage, and pathogen…”
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Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection by Glennon, Elizabeth K.K., Austin, Laura S., Arang, Nadia, Kain, Heather S., Mast, Fred D., Vijayan, Kamalakannan, Aitchison, John D., Kappe, Stefan H.I., Kaushansky, Alexis

“…Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell…”
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Protocol for assembling and implementing a partially automated system for rearing and handling Anopheles stephensi mosquitoes by Pitre, Zephyr, Seltzer, Tess, Kalthoff, Cecilia, Benitez-Cortez, Maria, Yee, Conrad, Glennon, Elizabeth K.K., Primavera, Veronica I., Kaushansky, Alexis

“…Live mosquitoes are required to comprehensively study vector-borne diseases, including transmission. Traditional mosquito-rearing protocols are laborious and…”
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Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry by Vijayan, Kamalakannan, Cestari, Igor, Mast, Fred D., Glennon, Elizabeth K.K., McDermott, Suzanne M., Kain, Heather S., Brokaw, Alyssa M., Aitchison, John D., Stuart, Kenneth, Kaushansky, Alexis

“…The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes,…”
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Abscisic acid: new perspectives on an ancient universal stress signaling molecule by Olds, Cassandra L., Glennon, Elizabeth K.K., Luckhart, Shirley

“…Few biological molecules have as far reaching and dynamic effects as abscisic acid (ABA). In this review, we draw together the often segregated fields of…”
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Opportunities for Host-targeted Therapies for Malaria by Glennon, Elizabeth K.K., Dankwa, Selasi, Smith, Joseph D., Kaushansky, Alexis

“…Despite the recent successes of artemisinin-based antimalarial drugs, many still die from severe malaria, and eradication efforts are hindered by the limited…”
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Host-targeted Interventions as an Exciting Opportunity to Combat Malaria by Vijayan, Kamalakannan, Wei, Ling, Glennon, Elizabeth K. K, Mattocks, Christa, Bourgeois, Natasha, Staker, Bart, Kaushansky, Alexis

“…Terminal and benign diseases alike in adults, children, pregnant women, and others are successfully treated by pharmacological inhibitors that target human…”
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Liver stage malaria infection is controlled by host regulators of lipid peroxidation by Kain, Heather S., Glennon, Elizabeth K. K., Vijayan, Kamalakannan, Arang, Nadia, Douglass, Alyse N., Fortin, Chelsea L., Zuck, Meghan, Lewis, Adam J., Whiteside, Samantha L., Dudgeon, Denali R., Johnson, Jarrod S., Aderem, Alan, Stevens, Kelly R., Kaushansky, Alexis

“…The facets of host control during Plasmodium liver infection remain largely unknown. We find that the SLC7a11-GPX4 pathway, which has been associated with the…”
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Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity by Dankwa, Selasi, Dols, Mary-Margaret, Wei, Ling, Glennon, Elizabeth K K, Kain, Heather S, Kaushansky, Alexis, Smith, Joseph D

“…Kinase inhibitors are promising drugs to stabilize the endothelial barrier following inflammatory damage. However, our limited knowledge of how kinase…”
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Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts by Rodríguez-Hernández, Diego, Vijayan, Kamalakannan, Zigweid, Rachael, Fenwick, Michael K., Sankaran, Banumathi, Roobsoong, Wanlapa, Sattabongkot, Jetsumon, Glennon, Elizabeth K. K., Myler, Peter J., Sunnerhagen, Per, Staker, Bart L., Kaushansky, Alexis, Grøtli, Morten

“…Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N…”
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Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage by Vijayan, Kamalakannan, Visweswaran, Ganesh Ram R., Chandrasekaran, Ramyavardhanee, Trakhimets, Olesya, Brown, Samantha L., Watson, Alexander, Zuck, Meghan, Dambrauskas, Nicholas, Raappana, Andrew, Carbonetti, Sara, Kelnhofer-Millevolte, Laurel, Glennon, Elizabeth K.K., Postiglione, Rachel, Sather, D. Noah, Kaushansky, Alexis

“…Both subunit and attenuated whole-sporozoite vaccination strategies against Plasmodium infection have shown promising initial results in malaria-naive…”
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Supplementation with Abscisic Acid Reduces Malaria Disease Severity and Parasite Transmission by Glennon, Elizabeth K K, Adams, L Garry, Hicks, Derrick R, Dehesh, Katayoon, Luckhart, Shirley

“…Nearly half of the world's population is at risk for malaria. Increasing drug resistance has intensified the need for novel therapeutics, including treatments…”
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Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/caspase-1-dependent immunity in Plasmodium yoelii-infected mice by Glennon, Elizabeth K. K., Megawati, Dewi, Torrevillas, Brandi K., Ssewanyana, Isaac, Huang, Liusheng, Aweeka, Fran, Greenhouse, Bryan, Adams, L. Garry, Luckhart, Shirley

“…Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation…”
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Elucidating Spatially-Resolved Changes in Host Signaling During Plasmodium Liver-Stage Infection by Glennon, Elizabeth K K, Tongogara, Tinotenda, Primavera, Veronica I, Reeder, Sophia M, Wei, Ling, Kaushansky, Alexis

“…Upon transmission to the human host, sporozoites exit the skin, are taken up by the blood stream, and then travel to the liver where they infect and…”
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Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity by Glennon, Elizabeth K K, Torrevillas, Brandi K, Morrissey, Shannon F, Ejercito, Jadrian M, Luckhart, Shirley

“…Abscisic acid (ABA) is naturally present in mammalian blood and circulating levels can be increased by oral supplementation. We showed previously that oral ABA…”
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Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection by Wang, Bo, Pakpour, Nazzy, Napoli, Eleonora, Drexler, Anna, Glennon, Elizabeth K K, Surachetpong, Win, Cheung, Kong, Aguirre, Alejandro, Klyver, John M, Lewis, Edwin E, Eigenheer, Richard, Phinney, Brett S, Giulivi, Cecilia, Luckhart, Shirley

“…Fruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of…”
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