Search Results - "Glenn Crater, Glenn"

431-P: Effects of CB1 Antagonist INV-202 in Patients with Metabolic Syndrome—A Randomized, Placebo-Controlled, Double-Blind Phase 1B Study by CRATER, GLENN D., RAVENELLE, FRANCOIS, LALONDE, KARINE, DESPRÉS, JEAN-PIERRE

“…Cannabinoid blockers have been successful for the treatment of obesity. However, due to CNS side effects drug development programs were halted. We present data…”
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A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19 by Singh, Dave, Bogus, Maxim, Moskalenko, Valentyn, Lord, Robert, Moran, Edmund J, Crater, Glenn D, Bourdet, David L, Pfeifer, Nathan D, Woo, Jacky, Kaufman, Elad, Lombardi, David A, Weng, Emily Y, Nguyen, Tuan, Woodcock, Ashley, Haumann, Brett, Saggar, Rajeev

“…Severe coronavirus disease 2019 (COVID-19) is characterised by pneumonia with excessive systemic inflammation, referred to as a “cytokine storm” [1–3]…”
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Once-Daily Umeclidinium/Vilanterol 125/25 μg Therapy in COPD by Celli, Bartolome, MD, FCCP, Crater, Glenn, MD, FCCP, Kilbride, Sally, MSc, Mehta, Rashmi, PhD, Tabberer, Maggie, MSc, Kalberg, Chris J., PhD, Church, Alison, MD

“…Background Combination long-acting bronchodilator therapy may be more effective than long-acting bronchodilator monotherapy in COPD. Our objectives were to…”
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Effects of CB1R inverse agonist, INV‐202, in patients with features of metabolic syndrome. A randomized, placebo‐controlled, double‐blind phase 1b study by Crater, Glenn D., Lalonde, Karine, Ravenelle, François, Harvey, Michael, Després, Jean‐Pierre

“…Aims To evaluate the clinical safety, tolerability, and pharmacokinetic and pharmacodynamic profile of the novel cannabinoid receptor‐1 (CB1R) inverse agonist,…”
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Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trials by Decramer, Marc, Dr Prof, Anzueto, Antonio, Prof, Kerwin, Edward, MD, Kaelin, Thomas, DO, Richard, Nathalie, MSc, Crater, Glenn, MD, Tabberer, Maggie, MSc, Harris, Stephanie, BSc, Church, Alison, MD

“…Summary Background Combination long-acting bronchodilator treatment might be more effective than long-acting bronchodilator monotherapy for the treatment of…”
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Priorities for future research into asthma diagnostic tools: A PAN‐EU consensus exercise from the European asthma research innovation partnership (EARIP) by Garcia‐Marcos, L., Edwards, J., Kennington, E., Aurora, P., Baraldi, E., Carraro, S., Gappa, M., Louis, R., Moreno‐Galdo, A., Peroni, D. G., Pijnenburg, M., Priftis, K. N., Sanchez‐Solis, M., Schuster, A., Walker, S., Blakey, John, Compton, Chris, Fleming, Louise, Fowler, Steve, Gaillard, Erol, Gibson, Frankie, Glenn Crater, Glenn, Niven, Rob, Roberts, Amanda, Ryan, Dermot, Seppala, Ulla, Usmani, Omar, Schee, Marc, Sont, Jacob

“…Summary The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective…”
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Peak Inspiratory Flows: Defining Repeatability Limits and a Predictive Equation for Different Inhalers by Barnes, Chris N, Mahler, Donald A, Ohar, Jill A, Lombardi, David A, Crater, Glenn D

“…Peak inspiratory flow (PIF) has been proposed as a measure to assess a patient's ability to use dry powder inhalers (DPIs). However, robust quality criteria to…”
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Safety, tolerability, pharmacodynamics and pharmacokinetics of umeclidinium and vilanterol alone and in combination: a randomized crossover trial by Kelleher, Dennis L, Mehta, Rashmi S, Jean-Francois, Bernadette M, Preece, Andrew F, Blowers, James, Crater, Glenn D, Thomas, Paul

“…Umeclidinium bromide (GSK573719; UMEC), a new long-acting muscarinic receptor antagonist (LAMA), is in development with vilanterol (GW642444; VI), a selective…”
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Clinical Burden of Chronic Obstructive Pulmonary Disease in Patients with Suboptimal Peak Inspiratory Flow by Ohar, Jill A., Mahler, Donald A., Davis, Gabrielle N., Lombardi, David A., Moran, Edmund J., Crater, Glenn D.

“…Introduction. Many patients with chronic obstructive pulmonary disease (COPD) may derive inadequate benefit from dry powder inhalers (DPIs) because of…”
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Lung deposition of inhaled once-daily long-acting muscarinic antagonists via standard jet nebulizer or dry powder inhaler, measured using functional respiratory imaging, in patients with chronic obstructive pulmonary disease by Crater, Glenn D., Johnson, Karmon, Ward, Jonathan, Backer, Jan De

“…Background: Data for bronchodilator deposition via nebulizers and dry powder inhalers (DPIs) in the respiratory tract of patients with chronic obstructive…”
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Maintained therapeutic effect of revefenacin over 52 weeks in moderate to very severe Chronic Obstructive Pulmonary Disease (COPD) by Donohue, James F, Kerwin, Edward, Sethi, Sanjay, Haumann, Brett, Pendyala, Srikanth, Dean, Lorna, Barnes, Chris N, Moran, Edmund J, Crater, Glenn

“…Revefenacin is a long-acting muscarinic antagonist that was recently approved for the nebulized treatment of chronic obstructive pulmonary disease (COPD)…”
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Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis by Donohue, James F, Kerwin, Edward, Barnes, Chris N, Moran, Edmund J, Haumann, Brett, Crater, Glenn D

“…Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 s (FEV ) in…”
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Longterm Survival Among Patients with Scleroderma-associated Pulmonary Arterial Hypertension Treated with Intravenous Epoprostenol by BADESCH, David B, MCGOON, Michael D, BARST, Robin J, TAPSON, Victor F, RUBIN, Lewis J, WIGLEY, Fredrick M, KRAL, Kenneth M, RAPHIOU, Ibrahim H, CRATER, Glenn D

“…Objective. Pulmonary arterial hypertension (PAH) remains challenging to treat, especially in association with scleroderma. We examined survival rates among…”
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Nebulized Versus Dry Powder Long-Acting Muscarinic Antagonist Bronchodilators in Patients With COPD and Suboptimal Peak Inspiratory Flow Rate by Mahler, Donald A, Ohar, Jill A, Barnes, Chris N, Moran, Edmund J, Pendyala, Srikanth, Crater, Glenn D

“…Patients with chronic obstructive pulmonary disease (COPD) and suboptimal peak inspiratory flow rate (sPIFR) may not benefit optimally from dry powder inhalers…”
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Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD by Hanania, Nicola A, Crater, Glenn D, Morris, Andrea N, Emmett, Amanda H, O’Dell, Dianne M, Niewoehner, Dennis E

“…Summary Background Combining maintenance medications with different mechanisms of action may improve outcomes in COPD. In this study we evaluated the efficacy…”
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Effects of a combination of umeclidinium/vilanterol on exercise endurance in patients with chronic obstructive pulmonary disease: two randomized, double-blind clinical trials by Maltais, François, Singh, Sally, Donald, Alison C, Crater, Glenn, Church, Alison, Goh, Aik H, Riley, John H

“…Exercise intolerance is a hallmark of chronic obstructive pulmonary disease (COPD). Patients with COPD were randomized in two multicentre, double-blind,…”
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Efficacy and safety of revefenacin for nebulization in patients with chronic obstructive pulmonary disease taking concomitant ICS/LABA or LABA: subgroup analysis from phase III trials by Sethi, Sanjay, Donohue, James F., Ferguson, Gary T., Barnes, Chris N., Crater, Glenn D.

“…Background: Combinations of a long-acting muscarinic receptor antagonist (LAMA), long-acting β-agonist (LABA), and inhaled corticosteroid (ICS) are used for…”
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Effect of fluticasone propionate/salmeterol (250/50) on COPD exacerbations and impact on patient outcomes by Anzueto, Antonio, Ferguson, Gary T, Feldman, Greg, Chinsky, Kenneth, Seibert, Allan, Emmett, Amanda, Knobil, Katharine, O'Dell, Dianne, Kalberg, Christopher, Crater, Glenn

“…Prevention and treatment of COPD exacerbations are recognized as key goals in disease management. This randomized, double-blind, parallel-group, multicenter…”
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Safety and Efficacy of Revefenacin and Formoterol in Sequence and Combination via a Standard Jet Nebulizer in Patients with Chronic Obstructive Pulmonary Disease: A Phase 3b, Randomized, 42-Day Study by Siler, Thomas M, Moran, Edmund J, Barnes, Chris N, Crater, Glenn D

“…Although no nebulized, dual mechanism, long-acting bronchodilator is currently marketed, with the approval of once-daily long-acting muscarinic antagonist…”
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Fluticasone propionate/salmeterol 250/50 μg versus salmeterol 50 μg after chronic obstructive pulmonary disease exacerbation by Ohar, Jill A, Crater, Glenn D, Emmett, Amanda, Ferro, Thomas J, Morris, Andrea N, Raphiou, Ibrahim, Sriram, Peruvemba S, Dransfield, Mark T

“…Inhaled long-acting beta2 agonists used alone and in combination with an inhaled corticosteroid reduce the risk of exacerbations in patients with stable COPD…”
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