Search Results - "Glendening, J M"

Advanced Glycation End Products Contribute to Amyloidosis in Alzheimer Disease by Vitek, Michael P., Bhattacharya, Keshab, Glendening, J. Michael, Stopa, Edward, Vlassara, Helen, Bucala, Richard, Manogue, Kirk, Cerami, Anthony

“…Alzheimer disease (AD) is characterized by deposits of an aggregated 42-amino-acid β-amyloid peptide (βAP) in the brain and cerebrovasculature. After a…”
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Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression by REED, J. A, LOGANZO, F. JR, ALBINO, A. P, SHEA, C. R, WALKER, G. J, FLORES, J. F, GLENDENING, J. M, BOGDANY, J. K, SHEIL, M. J, HALUSKA, F. G, FOUNTAIN, J. W

“…Sporadic and familial malignant melanoma susceptibility has been linked to defects in the chromosomal region 9p21. Recently, a putative 9p21 tumor suppressor…”
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Low frequency of p16/CDKN2A methylation in sporadic melanoma: Comparative approaches for methylation analysis of primary tumors by GONZALGO, M. L, BENDER, C. M, YOU, E. H, GLENDENING, J. M, FLORES, J. F, WALKER, G. J, HAYWARD, N. K, JONES, P. A, FOUNTAIN, J. W

“…Methylation of the 5' CpG island of the p16 tumor suppressor gene represents one possible mechanism for inactivation of this cell cycle regulatory gene that is…”
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PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines by Pollock, P M, Walker, G J, Glendening, J M, Que Noy, T, Bloch, N C, Fountain, J W, Hayward, N K

“…Deletions detected in cytogenetic and loss of heterozygosity (LOH) studies indicate that at least one tumour suppressor gene maps to the long arm of chromosome…”
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Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds by FLORES, J. F, POLLOCK, P. M, WALKER, G. J, GLENDENING, J. M, LIN, A. H.-T, PALMER, J. M, WALTERS, M. K, HAYWARD, N. K, FOUNTAIN, J. W

“…Germline mutations within the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and one of its targets, the cyclin dependent kinase 4 (CDK4) gene, have been…”
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Localization of Multiple Melanoma Tumor–Suppressor Genes on Chromosome 11 by Use of Homozygosity Mapping-of-Deletions Analysis by Goldberg, Eleonora K., Glendening, J. Michael, Karanjawala, Zarir, Sridhar, Anjali, Walker, Graeme J., Hayward, Nicholas K., Rice, Andrew J., Kurera, Devinda, Tebha, Yasmine, Fountain, Jane W.

“…Loss-of-heterozygosity (LOH) studies have implicated one or more chromosome 11 tumor-suppressor gene(s) in the development of cutaneous melanoma as well as a…”
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Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets by Walker, Graeme J., Flores, José F., Glendening, J. Michael, Lin, Amy (Hsui-Ti), Markl, Isabel D. C., Fountain, Jane W.

“…The cyclin‐dependent kinase inhibitor 2A (CDKN2A), or p16INK4a, gene on 9p21 is important in the genesis of both familial and sporadic melanoma. Homozygous…”
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Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice by Ali, S.M., Siedlak, S.L., Gonzalez-Dewhitt, P.A., Altman, R.A., Glendening, J.M., Lowery, D.E., Savage, M.J., Polities, H.G., Perry, G., Greenberg, B.D.

“…In an attempt to generate transgenic mice modeling Alzheimer-type amyloidogenesis, the COON-terminal 103 residue human APP segment was expressed in brain…”
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In vitro Loss of Heterozygosity Targets the PTEN/MMAC1 Gene in Melanoma by Robertson, Gavin P., Furnari, Frank B., Miele, Mary E., Glendening, Michael J., Welch, Danny R., Fountain, Jane W., Lugo, Tracy G., H.-J. Su Huang, Cavenee, Webster K.

“…Gross genetic lesions of chromosome 10 occur in 30-50% of sporadic human melanomas. To test the functional significance of this observation, we have developed…”
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Homozygous loss of the p15INK4B gene (and not the p1-INK4 gene) during tumor progression in a sporadic melanoma patient by GLENDENING, J. M, FLORES, J. F, WALKER, G. J, STONE, S, ALBINO, A. P, FOUNTAIN, J. W

“…Homozygous deletions of 9p21, including the cyclin-dependent kinase inhibitor genes p16INK4 and p15INK4B, have been reported frequently in melanoma (as well as…”
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Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds by Walker, G J, Hussussian, C J, Flores, J F, Glendening, J M, Haluska, F G, Dracopoli, N C, Hayward, N K, Fountain, J W

“…The cyclin dependent kinase inhibitor 2 (CDKN2) gene on chromosome 9p21 is potentially involved in the genesis of many cancers and is currently under intense…”
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Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma by FLORES, J. F, WALKER, G. J, BARNHILL, R. L, HAYWARD, N. K, HOUSMAN, D. E, FOUNTAIN, J. W, GLENDENING, J. M, HALUSKA, F. G, CASTRESANA, J. S, RUBIO, M.-P, PASTORFIDE, G. C, BOYER, L. A, KAO, W. H, BULYK, M. L

“…Although homozygous deletions of the cyclin-dependent kinase inhibitor 2 gene p16INK4a on 9p21 have been reported frequently in metastatic melanoma cell lines,…”
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Homozygous loss of the p15 super(INK4B) gene (and not the p16 super(INK4) gene) during tumor progression in a sporadic melanoma patient by Glendening, J M, Flores, J F, Walker, G J, Stone, S, Albino, AP, Fountain, J W

“…Homozygous deletions of 9p21, including the cyclin-dependent kinase inhibitor genes p16 super(INK4) and p15 super(INK4B), have been reported frequently in…”
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Loss of the p16 super(INK4a) and p15 super(INK4b) genes, as well as neighboring 9p21 markers, in sporadic melanoma by Flores, J F, Walker, G J, Glendening, J M, Haluska, F G, Castresana, J S, Rubio, M-P, Pastorfide, G C, Boyer, LA, Kao, W H, Bulyk, M L, Barnhill, R L, Hayward, N K, Housman, DE, Fountain, J W

“…Although homozygous deletions of the cyclin-dependent kinase inhibitor 2 gene p16 super(INK4a) on 9p21 have been reported frequently in metastatic melanoma…”
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Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice: Development of animal models of Alzheimer's disease: status of the field by ALI, S. M, SIEDLAK, S. L, GONZALEZ-DEWHITT, P. A, ALTMAN, R. A, GLENDENING, J. M, LOWERY, D. E, SAVAGE, M. J, POLITES, H. G, PERRY, G, GREENBERG, B. D

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