Search Results - "Glen, Katie"

Application of a simple unstructured kinetic and cost of goods models to support T‐cell therapy manufacture by Shariatzadeh, Maryam, Lopes, Adriana G., Glen, Katie E., Sinclair, Andrew, Thomas, Rob J.

“…Manufacturing of cell therapy products requires sufficient understanding of the cell culture variables and associated mechanisms for adequate control and risk…”
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A mechanistic model of erythroblast growth inhibition providing a framework for optimisation of cell therapy manufacturing by Glen, Katie E., Cheeseman, Elizabeth A., Stacey, Adrian J., Thomas, Robert J.

“…•A dynamic mechanistic model of erythroblast bioprocessing is defined.•The model predicts optimally efficient operation for erythroblast production.•The model…”
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Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: case studies by Ratcliffe, Elizabeth, Glen, Katie E, Naing, May Win, Williams, David J

“…Apart from haematopoietic stem cell transplantation for haematological disorders many stem cell-based therapies are experimental. However, with only 12 years…”
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Integrin-substrate interactions underlying shear-induced inhibition of the inflammatory response of endothelial cells by Luu, N Thin, Glen, Katie E, Egginton, Stuart, Rainger, G Ed, Nash, Gerard B

“…Conditioning of endothelial cells by shear stress suppresses their response to inflammatory cytokines. We questioned whether signalling through different…”
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Experimentally integrated dynamic modelling for intuitive optimisation of cell based processes and manufacture by Stacey, Adrian J., Cheeseman, Elizabeth A., Glen, Katie E., Moore, Rebecca L.L., Thomas, Robert J.

“…•Design of an intuitive framework for mechanistic modelling of cell-based processes.•Simplified model manipulation and communication via compatibility with…”
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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo by Ranganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G, Liu, Guang, Tran, Tran T, Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E, Graul, Chris, Griffin, Aliesha, Schairer, Wayne C, Higgins, Carolyn, Reza, Tammi L, Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim, Mandyam, Ramya A, Masferrer, Jaime, Liu, David, Patel, Dinesh V, Fretzen, Angelika, Murphy, Craig A, Milne, G Todd, Smythe, Mark L, Carlson, Kenneth E

“…Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6…”
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Immobilisation of Delta-like 1 ligand for the scalable and controlled manufacture of hematopoietic progenitor cells in a stirred bioreactor by Moore, Rebecca L L, Worrallo, Matthew J, Mitchell, Peter D, Harriman, Jon, Glen, Katie E, Thomas, Robert J

“…Umbilical cord blood provides a source of hematopoietic stem cells for transplantation with immunological and availability advantages over conventional bone…”
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Immobilized hematopoietic growth factors onto magnetic particles offer a scalable strategy for cell therapy manufacturing in suspension cultures by Worrallo, Matthew J., Moore, Rebecca L.L., Glen, Katie E., Thomas, Robert J.

“…Hematopoietic therapies require high cell dosages and precise phenotype control for clinical success; scalable manufacturing processes therefore need to be…”
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A quartz crystal resonator for cellular phenotyping by Granja, Carlos da Silva, Glen, Katie, Sandström, Niklas, Ostanin, Victor P., Thomas, Rob J., Ghosh, Sourav K.

“…Cell therapy manufacturing is limited by lack of online tools capable of realtime in-process monitoring, particularly of simultaneous changes in multiple…”
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Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoietic progenitor cells: process characterization, monitoring and implications for manufacture by Glen, Katie E, Workman, Victoria L, Ahmed, Forhad, Ratcliffe, Elizabeth, Stacey, Adrian J, Thomas, Robert J

“…Abstract Background aims Economic ex vivo manufacture of erythrocytes at 1012 cell doses requires an efficiently controlled bio-process capable of extensive…”
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Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation by Smith, David, Glen, Katie, Thomas, Robert

“…The translation of laboratory processes into scaled production systems suitable for manufacture is a significant challenge for cell based therapies; in…”
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Modeling the selective growth advantage of genetically variant human pluripotent stem cells to identify opportunities for manufacturing process control by Beltran-Rendon, Catherine, Price, Christopher J., Glen, Katie, Stacey, Adrian, Barbaric, Ivana, Thomas, Robert J.

“…The appearance of genetically variant populations in human pluripotent stem cell (hPSC) cultures represents a concern for research and clinical applications…”
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The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors by Bayley, Rachel, Ahmed, Forhad, Glen, Katie, McCall, Mark, Stacey, Adrian, Thomas, Robert

“…Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely…”
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The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors: The productivity limit of manufactured blood cell therapy by Bayley, Rachel, Ahmed, Forhad, Glen, Katie, McCall, Mark, Stacey, Adrian, Thomas, Robert

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Fat grafting versus implant-based treatment of breast asymmetry, a single surgeon experience over 13 years: a paradigm shift? by di Summa, Pietro G, Osinga, Rik, Sapino, Gianluca, Glen, Katie, Higgins, Gillian, Tay, Sherylin, Weiler-Mithoff, Eva

“…Breast asymmetry can result from congenital or traumatic aetiologies. Breast implants, autologous fat grafting, or a combination of both of these techniques…”
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Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: Differential effects of the mechanotransducer CD31 by Glen, Katie, Luu, N. Thin, Ross, Ewan, Buckley, Chris D., Rainger, G. Ed, Egginton, Stuart, Nash, Gerard B.

“…We investigated the roles of the “mechanotransducer” CD31 in the effects of shear stress on endothelial gene expression and functional responses relevant to…”
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Abstract 1589: Low shear stress induces the novel tumor endothelial marker CLEC14A that mediates cell migration and vascular development by Mura, Manuela, Zhuang, Xiadong, Vorschmitt, Henrik, Swain, Rajeeb K., Durant, Sarah, Herbert, John M., Sheldon, Helen, Andre, Maud, Sanderson, Sharon, Reynolds, Gary, Glen, Katie, Luu, Nguyet-Thin, McGettrick, Helen, Antczak, Phillip, Falciani, Francesco, Nash, Gerard, Nagy, Zsuzsanna, Bicknell, Roy

“…Experimental evidence using animal models has proven the efficacy of targeting a tumor endothelial marker (TEM) in eradicating large solid tumours. It follows…”
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