Search Results - "Gleichman, Amy J"

Glia in neurodegeneration: Drivers of disease or along for the ride? by Gleichman, Amy J., Carmichael, S. Thomas

“…While much of the research on neurodegenerative diseases has focused on neurons, non-neuronal cells are also affected. The extent to which glia and other…”
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Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study by Gresa-Arribas, Nuria, PhD, Titulaer, Maarten J, MD, Torrents, Abiguei, BS, Aguilar, Esther, McCracken, Lindsey, MPH, Leypoldt, Frank, MD, Gleichman, Amy J, PhD, Balice-Gordon, Rita, Prof, Rosenfeld, Myrna R, Prof, Lynch, David, Prof, Graus, Francesc, Prof, Dalmau, Josep, Prof

“…Summary Background Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a severe but treatable autoimmune disorder which diagnosis depends on sensitive…”
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Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain by Gleichman, Amy J, Spruce, Lynn A, Dalmau, Josep, Seeholzer, Steven H, Lynch, David R

“…Anti-NMDA receptor (NMDAR) encephalitis is a newly identified autoimmune disorder that targets NMDARs, causing severe neurological symptoms including…”
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Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies by Dalmau, Josep, MD, Gleichman, Amy J, BS, Hughes, Ethan G, BS, Rossi, Jeffrey E, BA, Peng, Xiaoyu, BS, Lai, Meizan, MD, Dessain, Scott K, MD, Rosenfeld, Myrna R, MD, Balice-Gordon, Rita, PhD, Lynch, David R, MD

“…Summary Background A severe form of encephalitis associated with antibodies against NR1–NR2 heteromers of the NMDA receptor was recently identified. We aimed…”
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Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis by Hughes, Ethan G, Peng, Xiaoyu, Gleichman, Amy J, Lai, Meizan, Zhou, Lei, Tsou, Ryan, Parsons, Thomas D, Lynch, David R, Dalmau, Josep, Balice-Gordon, Rita J

“…We recently described a severe, potentially lethal, but treatment-responsive encephalitis that associates with autoantibodies to the NMDA receptor (NMDAR) and…”
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A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences by Gleichman, Amy J., Kawaguchi, Riki, Sofroniew, Michael V., Carmichael, S. Thomas

“…Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function. Genetically manipulating…”
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Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents by Florance, Nicole R., Davis, Rebecca L., Lam, Christopher, Szperka, Christina, Zhou, Lei, Ahmad, Saba, Campen, Cynthia J., Moss, Heather, Peter, Nadja, Gleichman, Amy J., Glaser, Carol A., Lynch, David R., Rosenfeld, Myrna R., Dalmau, Josep

“…Objective To report the clinical features of anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in patients ≤ 18 years old. Methods Information was…”
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AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location by Lai, Meizan, Hughes, Ethan G., Peng, Xiaoyu, Zhou, Lei, Gleichman, Amy J., Shu, Huidy, Matà, Sabrina, Kremens, Daniel, Vitaliani, Roberta, Geschwind, Michael D., Bataller, Luis, Kalb, Robert G., Davis, Rebecca, Graus, Francesc, Lynch, David R., Balice-Gordon, Rita, Dalmau, Josep

“…Objective To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies…”
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NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury by Cook, Denise R., Gleichman, Amy J., Cross, Stephanie A., Doshi, Shachee, Ho, Wenzhe, Jordan‐Sciutto, Kelly L., Lynch, David R., Kolson, Dennis L.

“…J. Neurochem. (2011) 118, 1113–1123. Excitotoxic neuronal damage via over‐activation of the NMDA receptor has been implicated in many neurodegenerative…”
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Fyn-mediated Phosphorylation of NR2B Tyr-1336 Controls Calpain-mediated NR2B Cleavage in Neurons and Heterologous Systems by Wu, Hai-Yan, Hsu, Fu-Chun, Gleichman, Amy J., Baconguis, Isabelle, Coulter, Douglas A., Lynch, David R.

“…Cleavage of the intracellular carboxyl terminus of the N-methyl-d-aspartate (NMDA) receptor 2 subunit (NR2) by calpain regulates NMDA receptor function and…”
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Astrocytic therapies for neuronal repair in stroke by Gleichman, Amy J., Carmichael, S. Thomas

“…•Astrocytes are an under-investigated area of therapeutics for stroke recovery.•Changes in astrocytes may help or hurt neurons acutely after stroke.•Astrocytic…”
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Global and Local Processing in Adult Humans (Homo sapiens), 5-Year-Old Children (Homo sapiens), and Adult Cotton-Top Tamarins (Saguinus oedipus) by Neiworth, Julie J, Gleichman, Amy J, Olinick, Anne S, Lamp, Kristen E

“…This study compared adults ( Homo sapiens ), young children ( Homo sapiens ), and adult tamarins ( Saguinus oedipus ) while they discriminated global and local…”
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Motor Activity-Induced White Matter Repair in White Matter Stroke by Marin, Miguel A, Gleichman, Amy J, Wei, Xiaofei, Whittaker, Daniel S, Mody, Istvan, Colwell, Christopher S, Carmichael, S Thomas

“…Subcortical white matter stroke (WMS) is a progressive disorder which is demarcated by the formation of small ischemic lesions along white matter tracts in the…”
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Glutamatergic autoencephalitides: an emerging field by Panzer, Jessica A., Gleichman, Amy J., Lynch, David R.

“…Autoimmune responses targeting synaptic proteins are associated with a wide range of neurologic symptoms. Among these disorders are those associated with…”
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Subcortical White Matter Stroke in the Mouse: Inducing Injury and Tracking Cellular Proliferation by Marin, Miguel Alejandro, Gleichman, Amy J, Brumm, Andrew J, Carmichael, S Thomas

“…Here, we describe a method for inducing subcortical white matter stroke in mice, as well as tracking cellular proliferation through drinking water…”
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Antigenic and mechanistic characterization of anti‐AMPA receptor encephalitis by Gleichman, Amy J., Panzer, Jessica A., Baumann, Bailey H., Dalmau, Josep, Lynch, David R.

“…Objective Anti‐AMPAR encephalitis is a recently discovered disorder characterized by the presence of antibodies in serum or cerebrospinal fluid against the…”
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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology by Nunez, Stefanie, Doroudchi, M Mehdi, Gleichman, Amy J, Ng, Kwan L, Llorente, Irene L, Sozmen, Elif G, Carmichael, S Thomas, Hinman, Jason D

“…Stroke affecting white matter accounts for up to 25% of clinical stroke presentations, occurs silently at rates that may be 5-10 fold greater, and contributes…”
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Picking Up the Pieces: The Roles of Functional Remnants of Calpain-Mediated Proteolysis by Lynch, David R., Gleichman, Amy J.

“…Calpain-mediated cleavage of neuronal targets has long been associated with excitotoxicity and synaptic plasticity. In this issue of Neuron, two papers by Xu…”
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Diagnosis and significance of antibody titers in anti-NMDA receptor encephalitis, a retrospective study by Gresa-Arribas, Nuria, Titulaer, Maarten J., Torrents, Abiguei, Aguilar, Esther, McCracken, Lindsey, Leypoldt, Frank, Gleichman, Amy J., Balice-Gordon, Rita, Rosenfeld, Myrna R., Lynch, David, Graus, Francesc, Dalmau, Josep

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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology by Nunez, Stefanie, Doroudchi, M. Mehdi, Gleichman, Amy J., Ng, Kwan L., Llorente, Irene L., Sozmen, Elif G., Carmichael, S. Thomas, Hinman, Jason D.

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