Search Results - "Gledhill, Karl"

Pumpless microfluidic platform for drug testing on human skin equivalents by Abaci, Hasan Erbil, Gledhill, Karl, Guo, Zongyou, Christiano, Angela M, Shuler, Michael L

“…Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic…”
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Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells by Gledhill, Karl, Guo, Zongyou, Umegaki-Arao, Noriko, Higgins, Claire A, Itoh, Munenari, Christiano, Angela M

“…The current utility of 3D skin equivalents is limited by the fact that existing models fail to recapitulate the cellular complexity of human skin. They often…”
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Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model by Chantre, Christophe O., Campbell, Patrick H., Golecki, Holly M., Buganza, Adrian T., Capulli, Andrew K., Deravi, Leila F., Dauth, Stephanie, Sheehy, Sean P., Paten, Jeffrey A., Gledhill, Karl, Doucet, Yanne S., Abaci, Hasan E., Ahn, Seungkuk, Pope, Benjamin D., Ruberti, Jeffrey W., Hoerstrup, Simon P., Christiano, Angela M., Parker, Kevin Kit

“…Wounds in the fetus can heal without scarring. Consequently, biomaterials that attempt to recapitulate the biophysical and biochemical properties of fetal skin…”
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Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4 by Wojciechowicz, Kamila, Gledhill, Karl, Ambler, Carrie A, Manning, Craig B, Jahoda, Colin A B

“…The laboratory mouse is a key animal model for studies of adipose biology, metabolism and disease, yet the developmental changes that occur in tissues and…”
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Generation and characterization of multipotent stem cells from established dermal cultures by Hill, Rebecca P, Gledhill, Karl, Gardner, Aaron, Higgins, Claire A, Crawford, Heather, Lawrence, Clifford, Hutchison, Christopher J, Owens, William A, Kara, Bo, James, S Elizabeth, Jahoda, Colin A B

“…Human multipotent skin derived precursor cells (SKPs) are traditionally sourced from dissociated dermal tissues; therefore, donor availability may become…”
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Building a microphysiological skin model from induced pluripotent stem cells by Guo, Zongyou, Higgins, Claire A, Gillette, Brian M, Itoh, Munenari, Umegaki, Noriko, Gledhill, Karl, Sia, Samuel K, Christiano, Angela M

“…The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs…”
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Prostaglandin-E2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis-independent manner by Gledhill, Karl, Rhodes, Lesley E., Brownrigg, Margaret, Haylett, Ann K., Masoodi, Mojgan, Thody, Anthony J., Nicolaou, Anna, Tobin, Desmond J.

“…Summary Excessive ultraviolet radiation (UVR) exposure induces erythema, mediated in part by prostaglandin‐E2 (PGE2). While keratinocytes are a major PGE2…”
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sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases by Rhodes, Lesley E, Gledhill, Karl, Masoodi, Mojgan, Haylett, Ann K, Brownrigg, Margaret, Thody, Anthony J, Tobin, Desmond J, Nicolaou, Anna

“…Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV)…”
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Prostaglandin‐E 2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis‐independent manner by Gledhill, Karl, Rhodes, Lesley E., Brownrigg, Margaret, Haylett, Ann K., Masoodi, Mojgan, Thody, Anthony J., Nicolaou, Anna, Tobin, Desmond J.

“…Summary Excessive ultraviolet radiation (UVR) exposure induces erythema, mediated in part by prostaglandin‐E 2 (PGE 2 ). While keratinocytes are a major PGE 2…”
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The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn by Nicolaou, Anna, Masoodi, Mojgan, Gledhill, Karl, Haylett, Ann Katarina, Thody, Anthony John, Tobin, Desmond John, Rhodes, Lesley Elizabeth

“…High personal UVR doses can be gained during leisure activities, causing intense self-resolving inflammation (sunburn) of unprotected skin. UVR activates…”
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Correction: Development of the Mouse Dermal Adipose Layer Occurs Independently of Subcutaneous Adipose Tissue and Is Marked by Restricted Early Expression of FABP4 by Wojciechowicz, Kamila, Gledhill, Karl, Ambler, Carrie A., Manning, Craig B., Jahoda, Colin A. B.

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Prostaglandin D 2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production by Masoodi, Mojgan, Nicolaou, Anna, Gledhill, Karl, Rhodes, Lesley E., Tobin, Desmond J., Thody, Anthony J.

“…Please cite this paper as: Prostaglandin D 2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin…”
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Isolation and establishment of hair follicle dermal papilla cell cultures by Gledhill, Karl, Gardner, Aaron, Jahoda, Colin A B

“…The isolation of hair follicle dermal papilla cells has become an important technique in the field of cutaneous stem cell biology. These cells can be used for…”
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Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells: e0136713 by Gledhill, Karl, Guo, Zongyou, Umegaki-Arao, Noriko, Higgins, Claire A, Itoh, Munenari, Christiano, Angela M

“…The current utility of 3D skin equivalents is limited by the fact that existing models fail to recapitulate the cellular complexity of human skin. They often…”
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Dermal stem cells can differentiate down an endothelial lineage by Bell, Emma, Richardson, Gavin D, Jahoda, Colin A, Gledhill, Karl, Phillips, Helen M, Henderson, Deborah, Owens, W Andrew, Hole, Nicholas

“…In this study, we have demonstrated that cells of neural crest origin located in the dermal papilla (DP) exhibit endothelial marker expression and a functional…”
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Prostaglandin D2 production in FM55 melanoma cells is regulated by α-melanocyte-stimulating hormone and is not related to melanin production by Masoodi, Mojgan, Nicolaou, Anna, Gledhill, Karl, Rhodes, Lesley E., Tobin, Desmond J., Thody, Anthony J.

“…Please cite this paper as: Prostaglandin D2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin…”
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Correction: Development of the Mouse Dermal Adipose Layer Occurs Independently of Subcutaneous Adipose Tissue and Is Marked by Restricted Early Expression of FABP4 by Kamila Wojciechowicz, Karl Gledhill, Carrie A. Ambler, Craig B. Manning, Colin A. B. Jahoda

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The role of eicosanoids in the human skin's response to ultraviolet radiation by Gledhill, Karl

“…Erythema is a hallmark skin response to excessive ultraviolet radiation (UVR) and is associated with cutaneous inflammation. Both are mediated by inflammatory…”
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Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production by Masoodi, Mojgan, Nicolaou, Anna, Gledhill, Karl, Rhodes, Lesley E, Tobin, Desmond J, Thody, Anthony J

“…This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma…”
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