Search Results - "Gleave, Emma S"

Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis by Zhao, Gengjing, Gleave, Emma S, Lamers, Meindert Hugo

“…High fidelity replicative DNA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive oxygen species or UV light. To…”
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A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein by Gleave, Emma S., Schmidt, Helgo, Carter, Andrew P.

“…Dyneins are large protein complexes that act as microtubule based molecular motors. The dynein heavy chain contains a motor domain which is a member of the…”
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Insights into dynein motor domain function from a 3.3-Å crystal structure by Schmidt, Helgo, Gleave, Emma S, Carter, Andrew P

“…Dynein is a molecular motor involved in many cellular functions. The motor domain of dynein contains six AAA+ domains forming a ring that interacts with the…”
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration by Kettle, Jason G., Bagal, Sharan K., Barratt, Derek, Bodnarchuk, Michael S., Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J., Cosulich, Sabina, Davies, Michael, Davies, Nichola L., Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J., Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Cortés González, Miguel A., Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D., Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M., Lamont, Scott, Lewis, Hilary J., Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J., Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R., Ross, Sarah, Sanders, Matthew G., Schou, Magnus, Simpson, Iain, Steward, Oliver

“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration by Kettle, Jason G, Bagal, Sharan K, Barratt, Derek, Bodnarchuk, Michael S, Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J, Cosulich, Sabina, Davies, Michael, Davies, Nichola L, Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Cortés González, Miguel A, Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D, Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J, Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R, Ross, Sarah, Sanders, Matthew G, Schou, Magnus, Simpson, Iain, Steward, Oliver

“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C by Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J, Liu, Libin, Niedbala, Michael J, Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M, Ross, Sarah, Sanders, Matthew G, Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman

“…KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now…”
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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C by Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Boyd, Scott, Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Davies, Nichola L., Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Hanson, Lyndsey, Harlfinger, Stephanie, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Lamont, Gillian, Lamont, Scott, Lewis, Hilary J., Liu, Libin, Niedbala, Michael J., Phillips, Christopher, Polanski, Radek, Raubo, Piotr, Robb, Graeme, Robinson, David M., Ross, Sarah, Sanders, Matthew G., Tonge, Michael, Whiteley, Rebecca, Wilkinson, Stephen, Yang, Junsheng, Zhang, Wenman

“…KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now…”
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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS G12C by Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Harlfinger, Stephanie, Hanson, Lyndsey, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Kingston, Jennifer K, Lamont, Scott, Lewis, Hilary J, Li, Songlei, Liu, Libin, Ogg, Derek, Phillips, Christopher, Polanski, Radek, Robb, Graeme, Robinson, David, Ross, Sarah, Smith, James M, Tonge, Michael, Whiteley, Rebecca, Yang, Junsheng, Zhang, Longfei, Zhao, Xiliang

“…Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS mutant…”
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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C by Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Harlfinger, Stephanie, Hanson, Lyndsey, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Kingston, Jennifer K, Lamont, Scott, Lewis, Hilary J, Li, Songlei, Liu, Libin, Ogg, Derek, Phillips, Christopher, Polanski, Radek, Robb, Graeme, Robinson, David, Ross, Sarah, Smith, James M, Tonge, Michael, Whiteley, Rebecca, Yang, Junsheng, Zhang, Longfei, Zhao, Xiliang

“…Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRASG12C mutant…”
Get full text