Search Results - "Gleason, Ryan"
-
1
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans
Published in Current opinion in genetics & development (01-02-2023)“…Gametogenesis produces the only cell type within a metazoan that contributes both genetic and epigenetic information to the offspring. Extensive epigenetic…”
Get full text
Journal Article -
2
Protecting and Diversifying the Germline
Published in Genetics (Austin) (01-02-2018)“…Gametogenesis represents the most dramatic cellular differentiation pathways in both female and male flies. At the genome level, meiosis ensures that diploid…”
Get full text
Journal Article -
3
Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGFβ receptor in Caenorhabditis elegans
Published in PloS one (09-05-2019)“…The transforming growth factor-β (TGFβ) family plays an important role in many developmental processes and when mutated often contributes to various diseases…”
Get full text
Journal Article -
4
BMP signaling requires retromer-dependent recycling of the type I receptor
Published in Proceedings of the National Academy of Sciences - PNAS (18-02-2014)“…The transforming growth factor β (TGFβ) superfamily of signaling pathways, including the bone morphogenetic protein (BMP) subfamily of ligands and receptors,…”
Get full text
Journal Article -
5
C. elegans SMA-10 regulates BMP receptor trafficking
Published in PloS one (13-07-2017)“…Signal transduction of the conserved transforming growth factor-β (TGFβ) family signaling pathway functions through two distinct serine/threonine transmembrane…”
Get full text
Journal Article -
6
Symmetry from Asymmetry or Asymmetry from Symmetry?
Published in Cold Spring Harbor Symposia on Quantitative Biology (2017)“…The processes of DNA replication and mitosis allow the genetic information of a cell to be copied and transferred reliably to its daughter cells. However, if…”
Get full text
Journal Article -
7
Mutagenesis and Imaging Studies of BMP Signaling Mechanisms in C. elegans
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…C. elegans has played a central role in the elucidation of the TGFβ pathway over the last two decades. This is due to the high conservation of the pathway…”
Get more information
Journal Article -
8
Developmentally programmed histone H3 expression regulates cellular plasticity at the parental-to-early embryo transition
Published in Science advances (07-04-2023)“…During metazoan development, the marked change in developmental potential from the parental germline to the embryo raises an important question regarding how…”
Get full text
Journal Article -
9
Mechanical stimulation alters tissue differentiation and molecular expression during bone healing
Published in Journal of orthopaedic research (01-09-2009)“…Further understanding of how mechanical cues modulate skeletal tissue differentiation can identify potential means of enhancing repair following injury or…”
Get full text
Journal Article -
10
Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegans
Published in BMC developmental biology (07-06-2010)“…Bone morphogenetic proteins (BMPs) are members of the conserved transforming growth factor beta (TGFbeta superfamily, and play many developmental and…”
Get full text
Journal Article -
11
Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing
Published in Journal of biomechanics (26-08-2010)“…Abstract Defining how mechanical cues regulate tissue differentiation during skeletal healing can benefit treatment of orthopaedic injuries and may also…”
Get full text
Journal Article -
12
Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation
Published in Pigment cell and melanoma research (01-06-2008)“…Summary Previously, we reported a transgenic mouse line, TG‐3, that develops spontaneous melanoma with 100% penetrance. We demonstrated that ectopic expression…”
Get full text
Journal Article -
13
Mechanotransduction and Fracture Repair
Published in Journal of bone and joint surgery. American volume (01-02-2008)“…Fracture-healing is regulated in part by mechanical factors. Study of the processes by which the mechanical environment of a fracture modulates healing can…”
Get full text
Journal Article Conference Proceeding -
14
Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGF[beta] receptor in Caenorhabditis elegans
Published in PloS one (09-05-2019)“…The transforming growth factor-[beta] (TGF[beta]) family plays an important role in many developmental processes and when mutated often contributes to various…”
Get full text
Journal Article -
15
Analysis of TGFβ receptor trafficking and signaling
Published 01-01-2014“…Members of the transforming growth factor β (TGFβ) superfamily function in a compelling array of developmental processes. This family of secreted ligands, as…”
Get full text
Dissertation -
16
Mechanotransduction and Fracture Repair
Published in Journal of bone and joint surgery. American volume (2008)“…Fracture-healing is regulated in part by mechanical factors. Study of the processes by which the mechanical environment of a fracture modulates healing can…”
Get full text
Journal Article