Search Results - "Glazer, Peter"

Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair by Altwerger, Gary, Ghazarian, Maddie, Glazer, Peter M

“…Hypoxia is a hallmark feature of the tumor microenvironment which can promote mutagenesis and instability. This increase in mutational burden occurs as a…”
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The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells by Kim, Hoon, Lin, Qun, Glazer, Peter M, Yun, Zhong

“…Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that hypoxia can potentially maintain or…”
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Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing by Ricciardi, Adele S, Quijano, Elias, Putman, Rachael, Saltzman, W Mark, Glazer, Peter M

“…Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming a triplex structure capable of inducing DNA repair and producing…”
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Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment by Scanlon, Susan E., Glazer, Peter M.

“…Hypoxia, as a pervasive feature in the microenvironment of solid tumors, plays a significant role in cancer progression, metastasis, and ultimately clinical…”
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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway by Lu, Yuhong, Liu, Yanfeng, Oeck, Sebastian, Zhang, Gary J, Schramm, Alexander, Glazer, Peter M

“…Development of resistance remains the key obstacle to the clinical efficacy of EGFR tyrosine kinase inhibitors (TKI). Hypoxia is a key microenvironmental…”
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Impact of hypoxia on DNA repair and genome integrity by Kaplan, Alanna R, Glazer, Peter M

“…Abstract Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour biology, influencing cancer progression, the development of…”
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Oncometabolites suppress DNA repair by disrupting local chromatin signalling by Sulkowski, Parker L., Oeck, Sebastian, Dow, Jonathan, Economos, Nicholas G., Mirfakhraie, Lily, Liu, Yanfeng, Noronha, Katelyn, Bao, Xun, Li, Jing, Shuch, Brian M., King, Megan C., Bindra, Ranjit S., Glazer, Peter M.

“…Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer 1 . Increased levels of the metabolites 2-hydroxyglutarate, succinate and…”
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MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress by CROSBY, Meredith E, KULSHRESHTHA, Ritu, IVAN, Mircea, GLAZER, Peter M

“…Genetic instability is a hallmark of cancer; the hypoxic tumor microenvironment has been implicated as a cause of this phenomenon. MicroRNAs (miR) are small…”
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MicroRNA silencing for cancer therapy targeted to the tumour microenvironment by Cheng, Christopher J., Bahal, Raman, Babar, Imran A., Pincus, Zachary, Barrera, Francisco, Liu, Connie, Svoronos, Alexander, Braddock, Demetrios T., Glazer, Peter M., Engelman, Donald M., Saltzman, W. Mark, Slack, Frank J.

“…A novel anti-microRNA delivery platform that targets the acidic tumour microenvironment, in which a chosen anti-miRNA is coupled to a peptide that can…”
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity by Sulkowski, Parker L, Corso, Christopher D, Robinson, Nathaniel D, Scanlon, Susan E, Purshouse, Karin R, Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K, Hegan, Denise C, Fons, Nathan R, Breuer, Gregory A, Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk M, de Graaf, Robin A, Surovtseva, Yulia V, Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M, Bindra, Ranjit S

“…2-Hydroxyglutarate (2HG) exists as two enantiomers, (R)-2HG and (S)-2HG, and both are implicated in tumor progression via their inhibitory effects on…”
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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair by Sulkowski, Parker L., Sundaram, Ranjini K., Oeck, Sebastian, Corso, Christopher D., Liu, Yanfeng, Noorbakhsh, Seth, Niger, Monica, Boeke, Marta, Ueno, Daiki, Kalathil, Aravind Nambiar, Bao, Xun, Li, Jing, Shuch, Brian, Bindra, Ranjit S., Glazer, Peter M.

“…The hereditary cancer syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and succinate dehydrogenase–related hereditary paraganglioma and…”
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Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1 by Lu, Yuhong, Liu, Yanfeng, Oeck, Sebastian, Glazer, Peter M

“…The development of small-molecule tyrosine kinase inhibitors (TKI) specific for epidermal growth factor receptors (EGFR) with activating mutations has led to a…”
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Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation by Economos, Nicholas G, Quijano, Elias, Carufe, Kelly E W, Perera, J Dinithi R, Glazer, Peter M

“…Abstract Despite the rapid and broad implementation of CRISPR-Cas9-based technologies, convenient tools to modulate dose, timing, and precision remain limited…”
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microRNAs in cancer cell response to ionizing radiation by Czochor, Jennifer R, Glazer, Peter M

“…microRNAs (miRNA) have been characterized as master regulators of the genome. As such, miRNAs are responsible for regulating almost every cellular pathway,…”
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Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery by Hayman, Thomas J, Glazer, Peter M

“…Maintenance of genomic integrity is crucial for cell survival. As such, elegant DNA damage response (DDR) systems have evolved to ensure proper repair of DNA…”
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In utero nanoparticle delivery for site-specific genome editing by Ricciardi, Adele S., Bahal, Raman, Farrelly, James S., Quijano, Elias, Bianchi, Anthony H., Luks, Valerie L., Putman, Rachael, López-Giráldez, Francesc, Coşkun, Süleyman, Song, Eric, Liu, Yanfeng, Hsieh, Wei-Che, Ly, Danith H., Stitelman, David H., Glazer, Peter M., Saltzman, W. Mark

“…Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and…”
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Hypoxic tumor microenvironment and cancer cell differentiation by Kim, Yuri, Lin, Qun, Glazer, Peter M, Yun, Zhong

“…Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often resistant to conventional cancer therapies, and tumor hypoxia…”
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Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities by Quijano, Elias, Bahal, Raman, Ricciardi, Adele, Saltzman, W Mark, Glazer, Peter M

“…Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of chemical and biological assays. More recently, peptide nucleic acids…”
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Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response by Sahraei, Mahnaz, Chaube, Balkrishna, Liu, Yuting, Sun, Jonathan, Kaplan, Alanna, Price, Nathan L, Ding, Wen, Oyaghire, Stanley, García-Milian, Rolando, Mehta, Sameet, Reshetnyak, Yana K, Bahal, Raman, Fiorina, Paolo, Glazer, Peter M, Rimm, David L, Fernández-Hernando, Carlos, Suárez, Yajaira

“…microRNA-21 (miR-21) is the most commonly upregulated miRNA in solid tumors. This cancer-associated microRNA (oncomiR) regulates various downstream effectors…”
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Nanotechnology for delivery of peptide nucleic acids (PNAs) by Gupta, Anisha, Bahal, Raman, Gupta, Meera, Glazer, Peter M., Saltzman, W. Mark

“…Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous…”
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