Search Results - "Glassner, Brian J"

Molecular Basis for Discriminating between Normal and Damaged Bases by the Human Alkyladenine Glycosylase, AAG by Lau, A Y, Wyatt, M D, Glassner, B J, Samson, L D, Ellenberger, T

“…The human 3-methyladenine DNA glycosylase [alkyladenine DNA glycosylase (AAG)] catalyzes the first step of base excision repair by cleaving damaged bases from…”
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An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence by Dhimolea, Eugen, de Matos Simoes, Ricardo, Kansara, Dhvanir, Al’Khafaji, Aziz, Bouyssou, Juliette, Weng, Xiang, Sharma, Shruti, Raja, Joseline, Awate, Pallavi, Shirasaki, Ryosuke, Tang, Huihui, Glassner, Brian J., Liu, Zhiyi, Gao, Dong, Bryan, Jordan, Bender, Samantha, Roth, Jennifer, Scheffer, Michal, Jeselsohn, Rinath, Gray, Nathanael S., Georgakoudi, Irene, Vazquez, Francisca, Tsherniak, Aviad, Chen, Yu, Welm, Alana, Duy, Cihangir, Melnick, Ari, Bartholdy, Boris, Brown, Myles, Culhane, Aedin C., Mitsiades, Constantine S.

“…Treatment-persistent residual tumors impede curative cancer therapy. To understand this cancer cell state we generated models of treatment persistence that…”
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Generation of a strong mutator phenotype in yeast by imbalanced base excision repair by Glassner, B.J. (Harvard School of Public Health, Boston, MA.), Rasmussen, L.J, Najarian, M.T, Posnick, L.M, Samson, L.D

“…Increased spontaneous mutation is associated with increased cancer risk. Here, by using a model system, we show that spontaneous mutation can be increased…”
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Quantitative imaging of cells with multi-isotope imaging mass spectrometry (MIMS)—Nanoautography with stable isotope tracers by McMahon, Greg, Glassner, Brian J., Lechene, Claude P.

“…We describe some technical aspects of the application of multi-isotope imaging mass spectrometry (MIMS) to biological research, particularly the use of…”
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Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo by MORITZ, T, MACKAY, W, GLASSNER, B. J, WILLIAMS, D. A, SAMSON, L

“…Severe and delayed myelosuppression is a major side effect encountered with the clinical use of nitrosourea-type chemotherapeutic drugs. The DNA repair protein…”
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DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents by Glassner, Brian J., Weeda, Geert, Allan, James M., Broekhof, Jose' L.M., Carls, Nick H.E., Donker, Ingrid, Engelward, Bevin P., Hampson, Richard J., Hersmus, Remko, Hickman, Mark J., Roth, Richard B., Warren, Henry B., Wu, Mavis M., Hoeijmakers, Jan H.J., Samson, Leona D.

“…We have generated mice deficient in O6-methylguanine DNA methyltransferase activity encoded by the murine Mgmt gene using homologous recombination to delete…”
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Increasing DNA Repair Methyltransferase Levels Via Bone Marrow Stem Cell Transduction Rescues Mice from the Toxic Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a Chemotherapeutic Alkylating Agent by Maze, Rodney, Carney, James P., Kelley, Mark R., Glassner, Brian J., Williams, David A., Samson, Leona

“…The chloroethylnitrosourea (CNU) alkylating agents are commonly used for cancer chemotherapy, but their usefulness is limited by severe bone marrow toxicity…”
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Design of an automated multicapillary instrument with fraction collection for DNA mutation discovery by constant denaturant capillary electrophoresis (CDCE) by Li, Qingbo, Deka, Chiranjit, Glassner, Brian J., Arnold, Kevin, Li-Sucholeiki, Xiao-Cheng, Tomita-Mitchell, Aoy, Thilly, William G., Karger, Barry L.

“…A fundamental goal in genomics is the discovery of genetic variation that contributes to disease states or to differential drug responses. Single nucleotide…”
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Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance by Steinbrunn, Torsten, Shirasaki, Ryosuke, Dashevsky, Olga, Tang, Huihui, Yamano, Shizuka, Mizuno, Rin, Sugihara, Takeru, Teoh, Phaik Ju, Leypoldt, Lisa B, Kaji, Mariko, Sorrell, Jeffrey, Glassner, Brian J, De Matos Simoes, Ricardo, Christensen, James, Mitsiades, Constantine S

“…Oncogenic RAS mutations are frequent genomic drivers in hematologic neoplasias such as multiple myeloma (MM) but are traditionally considered non-“druggable”…”
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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins by Shirasaki, Ryosuke, Matthews, Geoffrey M., Gandolfi, Sara, de Matos Simoes, Ricardo, Buckley, Dennis L., Raja Vora, Joseline, Sievers, Quinlan L., Brüggenthies, Johanna B., Dashevsky, Olga, Poarch, Haley, Tang, Huihui, Bariteau, Megan A., Sheffer, Michal, Hu, Yiguo, Downey-Kopyscinski, Sondra L., Hengeveld, Paul J., Glassner, Brian J., Dhimolea, Eugen, Ott, Christopher J., Zhang, Tinghu, Kwiatkowski, Nicholas P., Laubach, Jacob P., Schlossman, Robert L., Richardson, Paul G., Culhane, Aedin C., Groen, Richard W.J., Fischer, Eric S., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Levy, Joan, Auclair, Daniel, Licht, Jonathan D., Keats, Jonathan J., Boise, Lawrence H., Ebert, Benjamin L., Bradner, James E., Gray, Nathanael S., Mitsiades, Constantine S.

“…Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent…”
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Abstract LB-118: Characterization of lineage vs. context-dependent essential genes in multiple myeloma using CRISPR-Cas9 genome editing by Matthews, Geoffrey M., Simoes, Ricardo de Matos, Hu, Yiguo, Sheffer, Michal, Dashevsky, Olga, Dhimolea, Eugen, Hengeveld, Paul J., Glassner, Brian J., Gandolfi, Sara, Bariteau, Megan A., Sievers, Quinlan, Ebert, Benjamin L., Vazquez, Franciska, Culhane, Aedin, Mitsiades, Constantine S.

“…Abstract Multiple Myeloma (MM) remains incurable in part due to an incomplete understanding of the genes critically responsible for MM cell survival and…”
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Gain-of-function studies with CRISPR-based transcriptional activation at endogenous genomic loci reveals genes with critical roles for myeloma cells by Tang, Huihui, Shirasaki, Ryosuke, Gandolfi, Sara, de Matos Simoes, Ricardo, Dashevsky, Olga, Glassner, Brian J., Downey-Kopyscinski, Sondra, Sheffer, Michal, Bariteau, Megan, Doench, John, Mitsiades, Constantine

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Combinatorial CRISPR-knockout identifies interactions between key genes and regulatory pathways in myeloma by Downey-Kopyscinski, Sondra, de Matos Simoes, Ricardo, Shirasaki, Ryosuke, Dashevsky, Olga, Gandolfi, Sara, Glassner, Brian J., Bariteau, Megan, Borah, Minasri, Groen, Richard, Doench, John, Mitsiades, Constantine

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Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias by de Matos Simoes, Ricardo, Shirasaki, Ryosuke, Downey-Kopyscinski, Sondra L, Matthews, Geoffrey M, Barwick, Benjamin G, Gupta, Vikas A, Dupéré-Richer, Daphné, Yamano, Shizuka, Hu, Yiguo, Sheffer, Michal, Dhimolea, Eugen, Dashevsky, Olga, Gandolfi, Sara, Ishiguro, Kazuya, Meyers, Robin M, Bryan, Jordan G, Dharia, Neekesh V, Hengeveld, Paul J, Brüggenthies, Johanna B, Tang, Huihui, Aguirre, Andrew J, Sievers, Quinlan L, Ebert, Benjamin L, Glassner, Brian J, Ott, Christopher J, Bradner, James E, Kwiatkowski, Nicholas P, Auclair, Daniel, Levy, Joan, Keats, Jonathan J, Groen, Richard W J, Gray, Nathanael S, Culhane, Aedin C, McFarland, James M, Dempster, Joshua M, Licht, Jonathan D, Boise, Lawrence H, Hahn, William C, Vazquez, Francisca, Tsherniak, Aviad, Mitsiades, Constantine S

“…Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC…”
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CRISPR-based functional genomics landscape of genes recurrently mutated in MM by de Matos Simoes, Ricardo, Shirasaki, Ryosuke, Tang, Huihui, Sheffer, Michal, Dashevsky, Olga, Downey-Kopyscinski, Sondra, Dhimolea, Eugen, Bariteau, Megan, Licht, Jonathan, Glassner, Brian J., Levy, Joan, Auclair, Daniel, Vazquez, Francisca, Tsherniak, Aviad, Hahn, William, Culhane, Aedin, Mitsiades, Constantine

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Molecular markers of myeloma cell sensitivity vs. resistance to heterobifunctional degraders of oncoproteins: therapeutic implications by Shirasaki, Ryosuke, de Matos Simoes, Ricardo, Gandolfi, Sara, Matthews, Geoffrey, Buckley, Dennis, Raja, Joseline, Sievers, Quinlan, Bruggenthies, Johanna, Dashevsky, Olga, Poarch, Haley, Tang, Huihui, Bariteau, Megan, Sheffer, Michal, Hu, Yiguo, Downey-Kopyscinski, Sondra, Hengeveld, Paul, Glassner, Brian J., Dhimolea, Eugen, Ott, Christopher, Zhang, Tinghu, Kwiatkowski, Nicholas, Laubach, Jacob, Schlossman, Robert, Culhane, Aedin, Richardson, Paul G., Groen, Richard, Fischer, Eric, Vazquez, Francisca, Tsherniak, Aviad, Hahn, William, Levy, Joan, Auclair, Daniel, Licht, Jonathan, Keats, Jonathan, Boise, Lawrence, Ebert, Benjamin, Bradner, James, Gray, Nathanael, Mitsiades, Constantine

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CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM by Shirasaki, Ryosuke, de Matos Simoes, Ricardo, Downey-Kopyscinski, Sondra, Matthews, Geoffrey, Hu, Yiguo, Sheffer, Michal, Dhimolea, Eugen, Dashevsky, Olga, Gandolfi, Sara, Hengeveld, Paul, Dempster, Joshua, Meyers, Robin, Bryan, Jordan, Dharia, Neekesh, McFarland, James, Sarkar, Subhashis, Bruggenthies, Johanna, Tang, Huihui, Bariteau, Megan, Aguirre, Andrew, Borah, Minasri, Sievers, Quinlan, Ebert, Benjamin, Raja, Joseline, Glassner, Brian J., Ott, Christopher, Bradner, James, Kwiatkowski, Nicholas, Auclair, Daniel, Levy, Joan, Poarch, Haley, Zhang, Tinghu, Laubach, Jacob, Buckley, Dennis, Schlossman, Robert, Groen, Richard, Fischer, Eric, Richardson, Paul G., Keats, Jonathan, Boise, Lawrence, Licht, Jonathan, Culhane, Aedin, Gray, Nathanael, Hahn, William, Vazquez, Francisca, Tsherniak, Aviad, Mitsiades, Constantine

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Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry by Li-Sucholeiki, Xiao-Cheng, Tomita-Mitchell, Aoy, Arnold, Kevin, Glassner, Brian J, Thompson, Terri, Murthy, Jaitra V, Berk, Lori, Lange, Craig, Leong-Morgenthaler, Phaik-Mooi, MacDougall, Damien, Munro, John, Cannon, Donald, Mistry, Trupti, Miller, Art, Deka, Chiranjit, Karger, Barry, Gillespie, Kathleen M, Ekstrøm, Per O, Todd, John A, Thilly, William G

“…DNA variants underlying the inheritance of risk for common diseases are expected to have a wide range of population allele frequencies. The detection and…”
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Specific negative effects resulting from elevated levels of the recombinational repair protein Rad54p in Saccharomyces cerevisiae by Clever, Beate, Schmuckli‐Maurer, Jacqueline, Sigrist, Markus, Glassner, Brian J., Heyer, Wolf‐Dietrich

“…RAD54 is an important gene in the RAD52 group that controls recombinational repair of DNA damage in Saccharomyces cerevisiae. Rad54p is a DNA‐dependent ATPase…”
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Specific negative effects resulting from elevated levels of the recombinational repair protein Rad54p inSaccharomyces cerevisiae by Clever, Beate, Schmuckli-Maurer, Jacqueline, Sigrist, Markus, Glassner, Brian J., Heyer, Wolf-Dietrich

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