Search Results - "Glassman, R"

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation by Glassman, Caleb R, Tsutsumi, Naotaka, Saxton, Robert A, Lupardus, Patrick J, Jude, Kevin M, Garcia, K Christopher

“…Cytokines signal through cell surface receptor dimers to initiate activation of intracellular Janus kinases (JAKs). We report the 3.6-angstrom-resolution…”
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Five-Year Outcomes after Initial Aflibercept, Bevacizumab, or Ranibizumab Treatment for Diabetic Macular Edema (Protocol T Extension Study) by Glassman, Adam R., Wells, John A., Josic, Kristin, Maguire, Maureen G., Antoszyk, Andrew N., Baker, Carl, Beaulieu, Wesley T., Elman, Michael J., Jampol, Lee M., Sun, Jennifer K.

“…Assess follow-up treatment and clinical outcomes at 5 years in eyes initially treated with anti-VEGF therapy for center-involved diabetic macular edema…”
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Expanded 2-Year Follow-up of Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema by Elman, Michael J., MD, Bressler, Neil M., MD, Qin, Haijing, MS, Beck, Roy W., MD, PhD, Ferris, Frederick L., MD, Friedman, Scott M., MD, Glassman, Adam R., MS, Scott, Ingrid U., MD, MPH, Stockdale, Cynthia R., MSPH, Sun, Jennifer K., MD, MPH

“…Objective To report expanded 2-year follow-up of a previously reported randomized trial evaluating intravitreal 0.5 mg ranibizumab or 4 mg triamcinolone…”
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Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema by Elman, Michael J., MD, Aiello, Lloyd Paul, MD, PhD, Beck, Roy W., MD, PhD, Bressler, Neil M., MD, Bressler, Susan B., MD, Edwards, Allison R., MS, Ferris, Frederick L., MD, Friedman, Scott M., MD, Glassman, Adam R., MS, Miller, Kellee M., MPH, Scott, Ingrid U., MD, MPH, Stockdale, Cynthia R., MSPH, Sun, Jennifer K., MD, MPH

“…Objective Evaluate intravitreal 0.5 mg ranibizumab or 4 mg triamcinolone combined with focal/grid laser compared with focal/grid laser alone for treatment of…”
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Collaborative Retrospective Macula Society Study of Photodynamic Therapy for Chronic Central Serous Chorioretinopathy by Lim, Jennifer I., MD, Glassman, Adam R., MS, Aiello, Lloyd Paul, MD, PhD, Chakravarthy, Usha, MD, Flaxel, Christina J., MD, Spaide, Richard F., MD

“…Purpose To assess the visual and anatomic outcomes of central serous chorioretinopathy (CSC) after verteporfin photodynamic therapy (PDT). Design Retrospective…”
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Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt versus Deferred Laser Treatment: 5-Year Randomized Trial Results by Elman, Michael J., MD, Ayala, Allison, MS, Bressler, Neil M., MD, Browning, David, MD, Flaxel, Christina J., MD, Glassman, Adam R., MS, Jampol, Lee M., MD, Stone, Thomas W., MD

“…Objective To report 5-year results from a previously reported trial evaluating intravitreal 0.5 mg ranibizumab with prompt versus deferred (for ≥24 weeks)…”
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Facile discovery of surrogate cytokine agonists by Yen, Michelle, Ren, Junming, Liu, Qingxiang, Glassman, Caleb R., Sheahan, Timothy P., Picton, Lora K., Moreira, Fernando R., Rustagi, Arjun, Jude, Kevin M., Zhao, Xiang, Blish, Catherine A., Baric, Ralph S., Su, Leon L., Garcia, K. Christopher

“…Cytokines are powerful immune modulators that initiate signaling through receptor dimerization, but natural cytokines have structural limitations as…”
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Automatic detection of hand hygiene using computer vision technology by Singh, Amit, Haque, Albert, Alahi, Alexandre, Yeung, Serena, Guo, Michelle, Glassman, Jill R, Beninati, William, Platchek, Terry, Fei-Fei, Li, Milstein, Arnold

“…Abstract Objective Hand hygiene is essential for preventing hospital-acquired infections but is difficult to accurately track. The gold-standard (human…”
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Structural basis of Janus kinase trans-activation by Caveney, Nathanael A., Saxton, Robert A., Waghray, Deepa, Glassman, Caleb R., Tsutsumi, Naotaka, Hubbard, Stevan R., Garcia, K. Christopher

“…Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to…”
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Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch by De Paula, Viviane S., Jude, Kevin M., Nerlie, Santrupti, Glassman, Caleb R., Garcia, K. Christopher, Sgourakis, Nikolaos G.

“…Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor…”
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Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination by Tsutsumi, Naotaka, Hwang, Sunhee, Waghray, Deepa, Hansen, Simon, Jude, Kevin M, Wang, Nan, Miao, Yi, Glassman, Caleb R, Caveney, Nathanael A, Janda, Claudia Y, Hannoush, Rami N, Garcia, K Christopher

“…Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific…”
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Repeated intravitreous ranibizumab injections for diabetic macular edema and the risk of sustained elevation of intraocular pressure or the need for ocular hypotensive treatment by Bressler, Susan B, Almukhtar, Talat, Bhorade, Anjali, Bressler, Neil M, Glassman, Adam R, Huang, Suber S, Jampol, Lee M, Kim, Judy E, Melia, Michele

“…For the management of retinal disease, the use of intravitreous injections of anti-vascular endothelial growth factor has increased. Recent reports have…”
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Structure of the IL-27 quaternary receptor signaling complex by Caveney, Nathanael A, Glassman, Caleb R, Jude, Kevin M, Tsutsumi, Naotaka, Garcia, K Christopher

“…Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis…”
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Investigating SARS-CoV-2 Test Positivity Calculations Across US Jurisdictions by Rivera, J., Schechtman, K., Glassman, R., Mart, M., Nguyen, Q.

“…Throughout the COVID-19 pandemic, many US epidemiologists and policymakers turned to an indicator called test positivity, or the percent of tests coming back…”
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Evaluating the Quality of Federal SARS-CoV-2 Diagnostic Testing Data by Schechtman, K., Rivera, J., Nguyen, Q., Glassman, R., Mart, M.

“…In April 2020, the US Department of Health and Human Services (HHS) and the US Centers for Disease Control and Prevention established the COVID-19 Electronic…”
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Methods for Counting COVID-19 Deaths in US States and Territories by Nguyen, Q., Rivera, J., Schechtman, K., Glassman, R., Mart, M.

“…The US Centers for Disease Control and Prevention (CDC) never issued guidelines on how states should publicly report COVID-19 deaths, and as a result, states…”
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A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ by Lee, Mark S., Glassman, Caleb R., Deshpande, Neha R., Badgandi, Hemant B., Parrish, Heather L., Uttamapinant, Chayasith, Stawski, Philipp S., Ting, Alice Y., Kuhns, Michael S.

“…The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell fate decisions. Yet how it relays ligand-specific information across…”
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Reproducibility of spectral-domain optical coherence tomography retinal thickness measurements and conversion to equivalent time-domain metrics in diabetic macular edema by Bressler, Susan B, Edwards, Allison R, Chalam, Kakarla V, Bressler, Neil M, Glassman, Adam R, Jaffe, Glenn J, Melia, Michele, Saggau, David D, Plous, Oren Z

“…Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for…”
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Factors Associated with Worsening Proliferative Diabetic Retinopathy in Eyes Treated with Panretinal Photocoagulation or Ranibizumab by Bressler, Susan B., MD, Beaulieu, Wesley T., PhD, Glassman, Adam R., MS, Gross, Jeffrey G., MD, Jampol, Lee M., MD, Melia, Michele, ScM, Peters, Mark A., MD, Rauser, Michael E., MD

“…Purpose To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with…”
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Panretinal Photocoagulation versus Ranibizumab for Proliferative Diabetic Retinopathy: Patient-Centered Outcomes from a Randomized Clinical Trial by Beaulieu, Wesley T, Bressler, Neil M, Melia, Michele, Owsley, Cynthia, Mein, Calvin E, Gross, Jeffrey G, Jampol, Lee M, Glassman, Adam R

“…Abstract Purpose Compare patient-centered outcomes in patients with proliferative diabetic retinopathy (PDR) treated with ranibizumab versus panretinal…”
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