The pharmacokinetics of ibuprofen suspension, chewable tablets, and tablets in children with cystic fibrosis

Objectives: The objectives of this study were to compare the pharmacokinetic parameters of ibuprofen administered as a suspension, chewable tablet, or tablet in children with cystic fibrosis and to determine the optimal blood sampling times for measuring ibuprofen peak concentrations. Study design:...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 134; no. 1; pp. 58 - 63
Main Authors:	Scott, Christy S., Retsch-Bogart, George Z., Kustra, Robert P., Graham, Katie M., Glasscock, Bradley J., Smith, Philip C.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 1999 Elsevier Mosby-Year Book, Inc
Subjects:	Administration, Oral Adolescent Analysis of Variance Area Under Curve Biological and medical sciences Child Child, Preschool Chromatography, High Pressure Liquid Cystic Fibrosis - metabolism Digestive system Female Half-Life Humans Ibuprofen - administration & dosage Ibuprofen - blood Ibuprofen - pharmacokinetics Male Medical sciences Pharmacology. Drug treatments Respiratory Function Tests Suspensions Tablets ANCOVA CF FEV 1 ANOVA GER C max T max Human Prostaglandin-endoperoxide synthase Respiratory disease Enzyme Enzyme inhibitor Metabolic diseases Cystic fibrosis Suspension Genetic disease Non steroidal antiinflammatory agent Chemotherapy Treatment Ibuprofen Digestive diseases Arylpropionic acid derivatives Tablet Oxidoreductases Pharmacokinetics Child Pancreatic disease
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Summary:	Objectives: The objectives of this study were to compare the pharmacokinetic parameters of ibuprofen administered as a suspension, chewable tablet, or tablet in children with cystic fibrosis and to determine the optimal blood sampling times for measuring ibuprofen peak concentrations. Study design: A single oral 20 mg/kg dose of ibuprofen was administered, and blood samples were obtained at 15, 30, 45, 60, 120, 240, and 360 minutes after the dose was administered. Peak plasma concentration (C max ), time to peak concentration (T max ), and other pharmacokinetic parameters were determined and compared (analysis of variance and analysis of covariance). Results: Thirty-eight children were included (22, 4, and 12 in the suspension, chewable tablet, and tablet groups, respectively). T max was the only parameter for which statistical differences were noted (suspension vs tablet, P ≤ .02). After age and sex were removed as potential confounding variables, T max remained statistically different ( P ≤ .001). Conclusions: A 20 mg/kg dose of ibuprofen suspension is recommended, with blood samples for pharmacokinetic analysis obtained 30, 45, and 60 minutes after the dose is administered. Obtaining the first blood sample 1 hour after dose administration will miss ~90% of peak concentrations, increasing the likelihood of overdosing. (J Pediatr 1999;134:58-63)
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(99)70387-2