Search Results - "Glass, Ian"

A human cell atlas of fetal gene expression by Cao, Junyue, O'Day, Diana R, Pliner, Hannah A, Kingsley, Paul D, Deng, Mei, Daza, Riza M, Zager, Michael A, Aldinger, Kimberly A, Blecher-Gonen, Ronnie, Zhang, Fan, Spielmann, Malte, Palis, James, Doherty, Dan, Steemers, Frank J, Glass, Ian A, Trapnell, Cole, Shendure, Jay

“…The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and…”
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A human cell atlas of fetal chromatin accessibility by Domcke, Silvia, Hill, Andrew J, Daza, Riza M, Cao, Junyue, O'Day, Diana R, Pliner, Hannah A, Aldinger, Kimberly A, Pokholok, Dmitry, Zhang, Fan, Milbank, Jennifer H, Zager, Michael A, Glass, Ian A, Steemers, Frank J, Doherty, Dan, Trapnell, Cole, Cusanovich, Darren A, Shendure, Jay

“…The chromatin landscape underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of chromatin accessibility…”
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In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution by Miller, Alyssa J., Yu, Qianhui, Czerwinski, Michael, Tsai, Yu-Hwai, Conway, Renee F., Wu, Angeline, Holloway, Emily M., Walker, Taylor, Glass, Ian A., Treutlein, Barbara, Camp, J. Gray, Spence, Jason R.

“…Bud tip progenitor cells give rise to all murine lung epithelial lineages and have been described in the developing human lung; however, the mechanisms…”
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Molecular Anatomy of the Developing Human Retina by Hoshino, Akina, Ratnapriya, Rinki, Brooks, Matthew J., Chaitankar, Vijender, Wilken, Matthew S., Zhang, Chi, Starostik, Margaret R., Gieser, Linn, La Torre, Anna, Nishio, Mario, Bates, Olivia, Walton, Ashley, Bermingham-McDonogh, Olivia, Glass, Ian A., Wong, Rachel O.L., Swaroop, Anand, Reh, Thomas A.

“…Clinical and genetic heterogeneity associated with retinal diseases makes stem-cell-based therapies an attractive strategy for personalized medicine. However,…”
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Spatial and cell type transcriptional landscape of human cerebellar development by Aldinger, Kimberly A., Thomson, Zachary, Phelps, Ian G., Haldipur, Parthiv, Deng, Mei, Timms, Andrew E., Hirano, Matthew, Santpere, Gabriel, Roco, Charles, Rosenberg, Alexander B., Lorente-Galdos, Belen, Gulden, Forrest O., O’Day, Diana, Overman, Lynne M., Lisgo, Steven N., Alexandre, Paula, Sestan, Nenad, Doherty, Dan, Dobyns, William B., Seelig, Georg, Glass, Ian A., Millen, Kathleen J.

“…The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint required to integrate environmental cues with developing motor,…”
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Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum by Haldipur, Parthiv, Aldinger, Kimberly A, Bernardo, Silvia, Deng, Mei, Timms, Andrew E, Overman, Lynne M, Winter, Conrad, Lisgo, Steven N, Razavi, Ferechte, Silvestri, Evelina, Manganaro, Lucia, Adle-Biassette, Homa, Guimiot, Fabien, Russo, Rosa, Kidron, Debora, Hof, Patrick R, Gerrelli, Dianne, Lindsay, Susan J, Dobyns, William B, Glass, Ian A, Alexandre, Paula, Millen, Kathleen J

“…We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in…”
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Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures by Sridhar, Akshayalakshmi, Hoshino, Akina, Finkbeiner, Connor R., Chitsazan, Alex, Dai, Li, Haugan, Alexandra K., Eschenbacher, Kayla M., Jackson, Dana L., Trapnell, Cole, Bermingham-McDonogh, Olivia, Glass, Ian, Reh, Thomas A.

“…To study the development of the human retina, we use single-cell RNA sequencing (RNA-seq) at key fetal stages and follow the development of the major cell…”
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Mutations in CSPP1 Cause Primary Cilia Abnormalities and Joubert Syndrome with or without Jeune Asphyxiating Thoracic Dystrophy by Tuz, Karina, Bachmann-Gagescu, Ruxandra, O’Day, Diana R., Hua, Kiet, Isabella, Christine R., Phelps, Ian G., Stolarski, Allan E., O’Roak, Brian J., Dempsey, Jennifer C., Lourenco, Charles, Alswaid, Abdulrahman, Bönnemann, Carsten G., Medne, Livija, Nampoothiri, Sheela, Stark, Zornitza, Leventer, Richard J., Topçu, Meral, Cansu, Ali, Jagadeesh, Sujatha, Done, Stephen, Ishak, Gisele E., Glass, Ian A., Shendure, Jay, Neuhauss, Stephan C.F., Haldeman-Englert, Chad R., Doherty, Dan, Ferland, Russell J.

“…Joubert syndrome (JBTS) is a recessive ciliopathy in which a subset of affected individuals also have the skeletal dysplasia Jeune asphyxiating thoracic…”
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Recessive mutations in >VPS13D cause childhood onset movement disorders by Gauthier, Julie, Meijer, Inge A., Lessel, Davor, Mencacci, Niccolò E., Krainc, Dimitri, Hempel, Maja, Tsiakas, Konstantinos, Prokisch, Holger, Rossignol, Elsa, Helm, Margaret H., Rodan, Lance H., Karamchandani, Jason, Carecchio, Miryam, Lubbe, Steven J., Telegrafi, Aida, Henderson, Lindsay B., Lorenzo, Kerry, Wallace, Stephanie E., Glass, Ian A., Hamdan, Fadi F., Michaud, Jacques L., Rouleau, Guy A., Campeau, Philippe M.

“…VPS13 protein family members VPS13A through VPS13C have been associated with various recessive movement disorders. We describe the first disease association of…”
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Unified rhombic lip origins of group 3 and group 4 medulloblastoma by Smith, Kyle S., Bihannic, Laure, Gudenas, Brian L., Haldipur, Parthiv, Tao, Ran, Gao, Qingsong, Li, Yiran, Aldinger, Kimberly A., Iskusnykh, Igor Y., Chizhikov, Victor V., Scoggins, Matthew, Zhang, Silu, Edwards, Angela, Deng, Mei, Glass, Ian A., Overman, Lynne M., Millman, Jake, Sjoboen, Alexandria H., Hadley, Jennifer, Golser, Joseph, Mankad, Kshitij, Sheppard, Heather, Onar-Thomas, Arzu, Gajjar, Amar, Robinson, Giles W., Hovestadt, Volker, Orr, Brent A., Patay, Zoltán, Millen, Kathleen J., Northcott, Paul A.

“…Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach…”
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Systematic Localization of Common Disease-Associated Variation in Regulatory DNA by Maurano, Matthew T., Humbert, Richard, Rynes, Eric, Thurman, Robert E., Haugen, Eric, Wang, Hao, Reynolds, Alex P., Sandstrom, Richard, Qu, Hongzhu, Brody, Jennifer, Shafer, Anthony, Neri, Fidencio, Lee, Kristen, Kutyavin, Tanya, Stehling-Sun, Sandra, Johnson, Audra K., Canfield, Theresa K., Giste, Erika, Diegel, Morgan, Bates, Daniel, Hansen, R. Scott, Neph, Shane, Sabo, Peter J., Heimfeld, Shelly, Raubitschek, Antony, Ziegler, Steven, Cotsapas, Chris, Sotoodehnia, Nona, Glass, Ian, Sunyaev, Shamil R., Kaul, Rajinder, Stamatoyannopoulos, John A.

“…Genome-wide association studies have identified many noncoding variants associated with common diseases and traits. We show that these variants are…”
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Charting human development using a multi-endodermal organ atlas and organoid models by Yu, Qianhui, Kilik, Umut, Holloway, Emily M., Tsai, Yu-Hwai, Harmel, Christoph, Wu, Angeline, Wu, Joshua H., Czerwinski, Michael, Childs, Charlie J., He, Zhisong, Capeling, Meghan M., Huang, Sha, Glass, Ian A., Higgins, Peter D.R., Treutlein, Barbara, Spence, Jason R., Camp, J. Gray

“…Organs are composed of diverse cell types that traverse transient states during organogenesis. To interrogate this diversity during human development, we…”
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Mapping Development of the Human Intestinal Niche at Single-Cell Resolution by Holloway, Emily M., Czerwinski, Michael, Tsai, Yu-Hwai, Wu, Joshua H., Wu, Angeline, Childs, Charlie J., Walton, Katherine D., Sweet, Caden W., Yu, Qianhui, Glass, Ian, Treutlein, Barbara, Camp, J. Gray, Spence, Jason R.

“…The human intestinal stem cell niche supports self-renewal and epithelial function, but little is known about its development. We used single-cell mRNA…”
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A near-infrared survey of Miras and the distance to the Galactic Centre by Matsunaga, Noriyuki, Kawadu, Takahiro, Nishiyama, Shogo, Nagayama, Takahiro, Hatano, Hirofumi, Tamura, Motohide, Glass, Ian S., Nagata, Tetsuya

“…We report the results of a near-infrared survey for long-period variables in a field of view of 20× 30 arcmin2 towards the Galactic Centre (GC). We have…”
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The Square Kilometre Array radio telescope: A media darling by Glass, Ian S

“…The stars in our eyes: Representations of the Square Kilometre Array telescope in the South African media, by Michael Gastrow is reviewed…”
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A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development by Yao, Zizhen, Mich, John K., Ku, Sherman, Menon, Vilas, Krostag, Anne-Rachel, Martinez, Refugio A., Furchtgott, Leon, Mulholland, Heather, Bort, Susan, Fuqua, Margaret A., Gregor, Ben W., Hodge, Rebecca D., Jayabalu, Anu, May, Ryan C., Melton, Samuel, Nelson, Angelique M., Ngo, N. Kiet, Shapovalova, Nadiya V., Shehata, Soraya I., Smith, Michael W., Tait, Leah J., Thompson, Carol L., Thomsen, Elliot R., Ye, Chaoyang, Glass, Ian A., Kaykas, Ajamete, Yao, Shuyuan, Phillips, John W., Grimley, Joshua S., Levi, Boaz P., Wang, Yanling, Ramanathan, Sharad

“…During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA…”
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Molecular genetic findings and clinical correlations in 100 patients with Joubert syndrome and related disorders prospectively evaluated at a single center by Vilboux, Thierry, Doherty, Daniel A., Glass, Ian A., Parisi, Melissa A., Phelps, Ian G., Cullinane, Andrew R., Zein, Wadih, Brooks, Brian P., Heller, Theo, Soldatos, Ariane, Oden, Neal L., Yildirimli, Deniz, Vemulapalli, Meghana, Mullikin, James C., NISC Comparative Sequencing Program, Malicdan, May Christine V., Gahl, William A., Gunay-Aygun, Meral

“…Purpose: Joubert syndrome (JS) is a genetically and clinically heterogeneous ciliopathy characterized by distinct cerebellar and brainstem malformations…”
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Differential Regulation of Immune-Related Genes in the Developing Heart by Garand, Mathieu, Huang, Susie S Y, Dineen, Brian, Glass, Ian A, Eghtesady, Pirooz

“…In many congenital heart defects, it can be difficult to ascertain primary pathology from secondary consequences from altered flow through the developing…”
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Joubert Syndrome: Ophthalmological Findings in Correlation with Genotype and Hepatorenal Disease in 99 Patients Prospectively Evaluated at a Single Center by Brooks, Brian P., Zein, Wadih M., Thompson, Amy H., Mokhtarzadeh, Maryam, Doherty, Daniel A., Parisi, Melissa, Glass, Ian A., Malicdan, May C., Vilboux, Thierry, Vemulapalli, Meghana, Mullikin, James C., Gahl, William A., Gunay-Aygun, Meral

“…Joubert syndrome (JS) is caused by mutations in >34 genes that encode proteins involved with primary (nonmotile) cilia and the cilium basal body. This study…”
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Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate by Cox, Liza L., Cox, Timothy C., Moreno Uribe, Lina M., Zhu, Ying, Richter, Chika T., Nidey, Nichole, Standley, Jennifer M., Deng, Mei, Blue, Elizabeth, Chong, Jessica X., Yang, Yueqin, Carstens, Russ P., Anand, Deepti, Lachke, Salil A., Smith, Joshua D., Dorschner, Michael O., Bedell, Bruce, Kirk, Edwin, Hing, Anne V., Venselaar, Hanka, Valencia-Ramirez, Luz C., Bamshad, Michael J., Glass, Ian A., Cooper, Jonathan A., Haan, Eric, Nickerson, Deborah A., van Bokhoven, Hans, Zhou, Huiqing, Krahn, Katy N., Buckley, Michael F., Murray, Jeffrey C., Lidral, Andrew C., Roscioli, Tony

“…Non-syndromic cleft lip with or without cleft palate (NS-CL/P) is one of the most common human birth defects and is generally considered a complex trait…”
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