Search Results - "Glass, Hannes"

Cell-Type-Dependent Recruitment Dynamics of FUS Protein at Laser-Induced DNA Damage Sites by Niu, Yu, Pal, Arun, Szewczyk, Barbara, Japtok, Julia, Naumann, Marcel, Glaß, Hannes, Hermann, Andreas

“…Increased signs of DNA damage have been associated to aging and neurodegenerative diseases. DNA damage repair mechanisms are tightly regulated and involve…”
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Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation by Tripathi, Priyanka, Guo, Haihong, Dreser, Alice, Yamoah, Alfred, Sechi, Antonio, Jesse, Christopher Marvin, Katona, Istvan, Doukas, Panagiotis, Nikolin, Stefan, Ernst, Sabrina, Aronica, Eleonora, Glaß, Hannes, Hermann, Andreas, Steinbusch, Harry, Feller, Alfred C., Bergmann, Markus, Jaarsma, Dick, Weis, Joachim, Goswami, Anand

“…Mutations in RNA binding proteins (RBPs) and in genes regulating autophagy are frequent causes of familial amyotrophic lateral sclerosis (fALS). The P56S…”
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Human Spinal Motor Neurons Are Particularly Vulnerable to Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients by Bräuer, Stefan, Günther, René, Sterneckert, Jared, Glaß, Hannes, Hermann, Andreas

“…Amyotrophic lateral sclerosis (ALS) is the most common and devastating motor neuron (MN) disease. Its pathophysiological cascade is still enigmatic. More than…”
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Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons by Grossmann, Dajana, Malburg, Nina, Glaß, Hannes, Weeren, Veronika, Sondermann, Verena, Pfeiffer, Julia F, Petters, Janine, Lukas, Jan, Seibler, Philip, Klein, Christine, Grünewald, Anne, Hermann, Andreas

“…It is generally believed that the pathogenesis of PINK1/parkin-related Parkinson's disease (PD) is due to a disturbance in mitochondrial quality control…”
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Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis by Glaß, Hannes, Neumann, Patrick, Pal, Arun, Reinhardt, Peter, Storch, Alexander, Sterneckert, Jared, Hermann, Andreas

“…Chorea acanthocytosis (ChAc), an ultra-rare devastating neurodegenerative disease, is caused by mutations in the gene, which encodes for the protein chorein…”
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Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling by Glaß, Hannes, Pal, Arun, Reinhardt, Peter, Sterneckert, Jared, Wegner, Florian, Storch, Alexander, Hermann, Andreas

“…Mutations in the VPS13A gene leading to depletion of chorein protein are causative for Chorea Acanthocytosis (ChAc), a rare devastating disease, which is…”
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Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium by Reichel, Felix, Kräter, Martin, Peikert, Kevin, Glaß, Hannes, Rosendahl, Philipp, Herbig, Maik, Rivera Prieto, Alejandro, Kihm, Alexander, Bosman, Giel, Kaestner, Lars, Hermann, Andreas, Guck, Jochen

“…Misshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc),…”
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Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human Motoneurons In Vitro by Glaß, Hannes, Jonitz-Heincke, Anika, Petters, Janine, Lukas, Jan, Bader, Rainer, Hermann, Andreas

“…Due to advances in surgical procedures and the biocompatibility of materials used in total joint replacement, more and younger patients are undergoing these…”
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Applied Bayesian Approaches for Research in Motor Neuron Disease by Temp, Anna G M, Naumann, Marcel, Hermann, Andreas, Glaß, Hannes

“…Statistical evaluation of empirical data is the basis of the modern scientific method. Available tools include various hypothesis tests for specific data…”
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The Erythrocyte Sedimentation Rate and Its Relation to Cell Shape and Rigidity of Red Blood Cells from Chorea-Acanthocytosis Patients in an Off-Label Treatment with Dasatinib by Rabe, Antonia, Kihm, Alexander, Darras, Alexis, Peikert, Kevin, Simionato, Greta, Dasanna, Anil Kumar, Glaß, Hannes, Geisel, Jürgen, Quint, Stephan, Danek, Adrian, Wagner, Christian, Fedosov, Dmitry A., Hermann, Andreas, Kaestner, Lars

“…Background: Chorea-acanthocytosis (ChAc) is a rare hereditary neurodegenerative disease with deformed red blood cells (RBCs), so-called acanthocytes, as a…”
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High content organelle trafficking enables disease state profiling as powerful tool for disease modelling by Pal, Arun, Glaß, Hannes, Naumann, Marcel, Kreiter, Nicole, Japtok, Julia, Sczech, Ronny, Hermann, Andreas

“…Neurodegenerative diseases pose a complex field with various neuronal subtypes and distinct differentially affected intra-neuronal compartments. Modelling of…”
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Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons by Kutschenko, Anna, Staege, Selma, Grütz, Karen, Glaß, Hannes, Kalmbach, Norman, Gschwendtberger, Thomas, Henkel, Lisa M, Heine, Johanne, Grünewald, Anne, Hermann, Andreas, Seibler, Philip, Wegner, Florian

“…Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by…”
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A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis by Freischmidt, Axel, Goswami, Anand, Limm, Katharina, Zimyanin, Vitaly L, Demestre, Maria, Glaß, Hannes, Holzmann, Karlheinz, Helferich, Anika M, Brockmann, Sarah J, Tripathi, Priyanka, Yamoah, Alfred, Poser, Ina, Oefner, Peter J, Böckers, Tobias M, Aronica, Eleonora, Ludolph, Albert C, Andersen, Peter M, Hermann, Andreas, Weis, Joachim, Reinders, Jörg, Danzer, Karin M, Weishaupt, Jochen H

“…Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in…”
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Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins by Abo-Rady, Masin, Kalmbach, Norman, Pal, Arun, Schludi, Carina, Janosch, Antje, Richter, Tanja, Freitag, Petra, Bickle, Marc, Kahlert, Anne-Karin, Petri, Susanne, Stefanov, Stefan, Glass, Hannes, Staege, Selma, Just, Walter, Bhatnagar, Rajat, Edbauer, Dieter, Hermann, Andreas, Wegner, Florian, Sterneckert, Jared L.

“…In amyotrophic lateral sclerosis (ALS) motor neurons (MNs) undergo dying-back, where the distal axon degenerates before the soma. The hexanucleotide repeat…”
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Restoring Axonal Organelle Motility and Regeneration in Cultured FUS-ALS Motoneurons through Magnetic Field Stimulation Suggests an Alternative Therapeutic Approach by Kandhavivorn, Wonphorn, Glaß, Hannes, Herrmannsdörfer, Thomas, Böckers, Tobias M, Uhlarz, Marc, Gronemann, Jonas, Funk, Richard H W, Pietzsch, Jens, Pal, Arun, Hermann, Andreas

“…Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease characterized by sustained loss of neuromuscular junctions, degenerating corticospinal…”
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Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis by Peikert, Kevin, Federti, Enrica, Matte, Alessandro, Constantin, Gabriela, Pietronigro, Enrica Caterina, Fabene, Paolo Francesco, Defilippi, Paola, Turco, Emilia, Del Gallo, Federico, Pucci, Pietro, Amoresano, Angela, Illiano, Anna, Cozzolino, Flora, Monti, Maria, Garello, Francesca, Terreno, Enzo, Alper, Seth Leo, Glaß, Hannes, Pelzl, Lisann, Akgün, Katja, Ziemssen, Tjalf, Ordemann, Rainer, Lang, Florian, Brunati, Anna Maria, Tibaldi, Elena, Andolfo, Immacolata, Iolascon, Achille, Bertini, Giuseppe, Buffelli, Mario, Zancanaro, Carlo, Lorenzetto, Erika, Siciliano, Angela, Bonifacio, Massimiliano, Danek, Adrian, Walker, Ruth Helen, Hermann, Andreas, De Franceschi, Lucia

“…Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our…”
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Differentiation Efficiency of Induced Pluripotent Stem Cells Depends on the Number of Reprogramming Factors by Löhle, Matthias, Hermann, Andreas, Glaß, Hannes, Kempe, Andrea, Schwarz, Sigrid C., Kim, Jeong Beom, Poulet, Claire, Ravens, Ursula, Schwarz, Johannes, Schöler, Hans R., Storch, Alexander

“…Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by retroviral overexpression of the transcription factors Oct4, Sox2, Klf4, and…”
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Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS by Pal, Arun, Grossmann, Dajana, Glaß, Hannes, Zimyanin, Vitaly, Günther, René, Catinozzi, Marica, Boeckers, Tobias M, Sterneckert, Jared, Storkebaum, Erik, Petri, Susanne, Wegner, Florian, Grill, Stephan W, Pan-Montojo, Francisco, Hermann, Andreas

“…Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the…”
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Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons by Zimyanin, Vitaly L, Pielka, Anna-Maria, Glaß, Hannes, Japtok, Julia, Großmann, Dajana, Martin, Melanie, Deussen, Andreas, Szewczyk, Barbara, Deppmann, Chris, Zunder, Eli, Andersen, Peter M, Boeckers, Tobias M, Sterneckert, Jared, Redemann, Stefanie, Storch, Alexander, Hermann, Andreas

“…Motoneurons are one of the most energy-demanding cell types and a primary target in Amyotrophic lateral sclerosis (ALS), a debilitating and lethal…”
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Reduced Expression of GABA A Receptor Alpha2 Subunit Is Associated With Disinhibition of DYT-THAP1 Dystonia Patient-Derived Striatal Medium Spiny Neurons by Staege, Selma, Kutschenko, Anna, Baumann, Hauke, Glaß, Hannes, Henkel, Lisa, Gschwendtberger, Thomas, Kalmbach, Norman, Klietz, Martin, Hermann, Andreas, Lohmann, Katja, Seibler, Philip, Wegner, Florian

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