Search Results - "Glass, Christopher"

Molecular control of activation and priming in macrophages by Glass, Christopher K, Natoli, Gioacchino

“…Glass and Natoli review recent advances in the understanding of mechanisms underlying priming and signal-dependent activation of macrophages, and discuss the…”
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Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities by Tabas, Ira, Glass, Christopher K.

“…A number of widespread and devastating chronic diseases, including atherosclerosis, type 2 diabetes, and Alzheimer's disease, have a pathophysiologically…”
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Microglial cell origin and phenotypes in health and disease by Glass, Christopher K, Saijo, Kaoru

“…Key Points In the central nervous system, microglia have important roles in maintaining tissue homeostasis and responding to infection and injury. Microglia in…”
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The choreography of neuroinflammation in Huntington's disease by Crotti, Andrea, Glass, Christopher K

“…Highlights • The etiology and role of inflammation in neurodegenerative diseases is unclear. • In HD, mutant Huntingtin in microglia promotes proinflammatory…”
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The selection and function of cell type-specific enhancers by Heinz, Sven, Romanoski, Casey E., Benner, Christopher, Glass, Christopher K.

“…Key Points Enhancers are genetic elements that have major roles in determining cell type-specific gene expression patterns and responses to internal and…”
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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells by Glass, Christopher K, Saijo, Kaoru

“…Key Points Members of the nuclear receptor superfamily of transcription factors have important roles in modulating the responses of macrophages, microglia and…”
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Microbiome-microglia connections via the gut-brain axis by Abdel-Haq, Reem, Schlachetzki, Johannes C M, Glass, Christopher K, Mazmanian, Sarkis K

“…Microglia, the resident immune cells in the brain, are essential for modulating neurogenesis, influencing synaptic remodeling, and regulating neuroinflammation…”
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Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription by Kaikkonen, Minna U., Spann, Nathanael J., Heinz, Sven, Romanoski, Casey E., Allison, Karmel A., Stender, Joshua D., Chun, Hyun B., Tough, David F., Prinjha, Rab K., Benner, Christopher, Glass, Christopher K.

“…Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers,…”
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Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities by Gosselin, David, Link, Verena M., Romanoski, Casey E., Fonseca, Gregory J., Eichenfield, Dawn Z., Spann, Nathanael J., Stender, Joshua D., Chun, Hyun B., Garner, Hannah, Geissmann, Frederic, Glass, Christopher K.

“…Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue…”
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Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity by Phan, Anthony T., Goldrath, Ananda W., Glass, Christopher K.

“…Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to promote effective resolution of infection. To…”
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Transcriptional control of microglia phenotypes in health and disease by Holtman, Inge R, Skola, Dylan, Glass, Christopher K

“…Microglia are the main resident macrophage population of the CNS and perform numerous functions required for CNS development, homeostasis, immunity, and…”
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Macrophages, inflammation, and insulin resistance by Olefsky, Jerrold M, Glass, Christopher K

“…Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong risk factor for the development of type 2 diabetes mellitus…”
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Sterols and oxysterols in immune cell function by Spann, Nathanael J, Glass, Christopher K

“…Sterols and oxysterol derivatives of cholesterol regulate diverse cellular processes. Nathanael Spann and Christopher Glass review the emerging data indicating…”
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Mechanisms Underlying Inflammation in Neurodegeneration by Glass, Christopher K., Saijo, Kaoru, Winner, Beate, Marchetto, Maria Carolina, Gage, Fred H.

“…Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and…”
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Monocyte Regulation in Homeostasis and Malignancy by Robinson, Amy, Han, Claudia Z., Glass, Christopher K., Pollard, Jeffrey W.

“…Monocytes are progenitors to macrophages and a subclass of dendritic cells (monocyte-derived dendritic cells, MoDCs), but they also act as circulating sensors…”
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PPARs and molecular mechanisms of transrepression by Ricote, Mercedes, Glass, Christopher K.

“…In the last few years, PPARs have emerged as key regulators of inflammatory and immune responses. However, the mechanistic basis of the anti-inflammatory…”
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Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20 by Stender, Joshua D., Pascual, Gabriel, Liu, Wen, Kaikkonen, Minna U., Do, Kevin, Spann, Nathanael J., Boutros, Michael, Perrimon, Norbert, Rosenfeld, Michael G., Glass, Christopher K.

“…Regulation of genes that initiate and amplify inflammatory programs of gene expression is achieved by signal-dependent exchange of coregulator complexes that…”
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An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation by Saijo, Kaoru, Collier, Jana G., Li, Andrew C., Katzenellenbogen, John A., Glass, Christopher K.

“…Microglia and astrocytes play essential roles in the maintenance of homeostasis within the central nervous system, but mechanisms that control the magnitude…”
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Enhancer RNAs and regulated transcriptional programs by Lam, Michael T.Y., Li, Wenbo, Rosenfeld, Michael G., Glass, Christopher K.

“…•Active enhancers generate enhancer-derived RNAs (eRNAs).•At least some eRNAs contribute to enhancer function.•eRNAs may play roles in enhancer–promoter…”
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The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response by Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter

“…Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN…”
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