Search Results - "Glasnov, Toma N."

The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous-Flow Processes by Glasnov, Toma N., Kappe, C. Oliver

“…The popularity of dedicated microwave reactors in many academic and industrial laboratories has produced a plethora of synthetic protocols that are based on…”
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Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors by Irfan, Muhammad, Glasnov, Toma N., Kappe, C. Oliver

“…Microreactor technology and continuous flow processing in general are key features in making organic synthesis both more economical and environmentally…”
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Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions: A Comparison of Batch/Microwave and Continuous-Flow Processing by Glasnov, Toma N., Findenig, Silvia, Kappe, C. Oliver

“…Mizoroki–Heck couplings of aryl iodides and bromides with butyl acrylate were investigated as model systems to perform transition‐metal‐catalyzed…”
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An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel by Lichtenegger, Michaela, Tiapko, Oleksandra, Svobodova, Barbora, Stockner, Thomas, Glasnov, Toma N., Schreibmayer, Wolfgang, Platzer, Dieter, de la Cruz, Gema Guedes, Krenn, Sarah, Schober, Romana, Shrestha, Niroj, Schindl, Rainer, Romanin, Christoph, Groschner, Klaus

“…Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and…”
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Microwave-Assisted Synthesis under Continuous-Flow Conditions by Glasnov, Toma N., Kappe, C. Oliver

“…Microwave‐assisted chemistry is about to change the art and practice of synthesis performed in many academic and industrial laboratories. One of the major…”
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Continuous Flow Ozonolysis in a Laboratory Scale Reactor by Irfan, Muhammad, Glasnov, Toma N, Kappe, C. Oliver

“…Several important types of ozonolysis reactions have been performed in a continuous flow device that is able to perform both the ozonolysis and quenching steps…”
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Continuous‐Flow Microreactor Chemistry under High‐Temperature/Pressure Conditions by Razzaq, Tahseen, Glasnov, Toma N., Kappe, C. Oliver

“…High‐temperature organic synthesis can be performed under continuous‐flow conditions in a stainless steel microtubular flow reactor capable of achieving…”
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Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes by Damm, Markus, Glasnov, Toma N, Kappe, C. Oliver

“…A comparison between batch microwave and conventionally heated continuous flow scale-up protocols for three selected model reactions is presented. Using…”
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Microwave-Assisted Cross-Coupling and Hydrogenation Chemistry by Using Heterogeneous Transition-Metal Catalysts: An Evaluation of the Role of Selective Catalyst Heating by Irfan, Muhammed, Fuchs, Michael, Glasnov, Toma N., Kappe, C. Oliver

“…The concept of specific microwave effects in solid/liquid catalytic processes resulting from the selective heating of a microwave‐absorbing heterogeneous…”
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A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones by Viviano, Monica, Glasnov, Toma N, Reichart, Benedik, Tekautz, Guenter, Kappe, C. Oliver

“…Three different continuous flow strategies for the generation of important 4-aryl-2-butanone derivatives including the anti-inflammatory drug nabumetone…”
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Continuous Flow Hydrogenation of Functionalized Pyridines by Irfan, Muhammed, Petricci, Elena, Glasnov, Toma N., Taddei, Maurizio, Kappe, C. Oliver

“…The heterogeneous hydrogenation of substituted pyridines has been accomplished by employing a continuous flow hydrogenation device that incorporates in situ…”
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PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes by Poteser, Michael, Schleifer, Hannes, Lichtenegger, Michaela, Schernthaner, Michaela, Stockner, Thomas, Kappe, C. Oliver, Glasnov, Toma N, Romanin, Christoph, Groschner, Klaus

“…Cardiac transient receptor potential canonical (TRPC) channels are crucial upstream components of Ca²⁺/calcineurin/nuclear factor of activated T cells…”
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A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling by Koenig, Sarah, Schernthaner, Michaela, Maechler, Heinrich, Kappe, C Oliver, Glasnov, Toma N, Hoefler, Gerald, Braune, Marlen, Wittchow, Eric, Groschner, Klaus

“…TRPC-mediated Ca(2+) entry has been implicated in the control of smooth muscle proliferation and might represent a pivotal mechanism underlying in-stent…”
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Microwave-assisted continuous flow synthesis on industrial scale by Morschhäuser Roman, Krull Matthias, Kayser Christoph, Boberski Cornelia, Bierbaum Ralf, Püschner Peter A., Glasnov Toma N., Kappe C. Oliver

“…A continuous flow microwave system based on a transmission line short-circuited waveguide reactor concept is described. The continuous flow reactor is capable…”
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Microwave-Assisted Multistep Synthesis of Functionalized 4-Arylquinolin-2(1H)-ones Using Palladium-Catalyzed Cross-Coupling Chemistry by Glasnov, Toma N, Stadlbauer, Wolfgang, Kappe, C. Oliver

“…Biologically active 4-aryl-3-alkenyl-substituted quinolin-2(1H)-ones have been synthesized in a short and concise manner employing readily available…”
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High-Speed Microwave-Assisted Synthesis of the Trifluoromethylpyrazol-Derived Canonical Transient Receptor Potential (TRPC) Channel Inhibitor Pyr3 by Glasnov, Toma N., Groschner, Klaus, Kappe, C. Oliver

“…Process intensification using controlled microwave heating allows an efficient three‐step synthesis of pyrazole‐based inhibitors of TRPC3 and related NFAT…”
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Toward a Continuous-Flow Synthesis of Boscalid by Glasnov, Toma N., Kappe, C. Oliver

“…A two‐step continuous‐flow protocol for the synthesis of 2‐amino‐4′‐chlorobiphenyl, a key intermediate for the industrial preparation of the fungicide…”
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Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor by Gutmann, Bernhard, Glasnov, Toma N, Razzaq, Tahseen, Goessler, Walter, Roberge, Dominique M, Kappe, C Oliver

“…The decomposition of 5-benzhydryl-1H-tetrazole in an N-methyl-2-pyrrolidone/acetic acid/water mixture was investigated under a variety of high-temperature…”
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Photoswitching of model ion channels in lipid bilayers by Pfeffermann, Juergen, Eicher, Barbara, Boytsov, Danila, Hannesschlaeger, Christof, Galimzyanov, Timur R., Glasnov, Toma N., Pabst, Georg, Akimov, Sergey A., Pohl, Peter

“…Membrane proteins can be regulated by alterations in material properties intrinsic to the hosting lipid bilayer. Here, we investigated whether the reversible…”
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Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides by Obermayer, David, Glasnov, Toma N, Kappe, C. Oliver

“…A series of 4-(pyrazol-1-yl)carboxanilides active as inhibitors of canonical transient receptor potential channels were synthesized in an efficient three-step…”
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