Search Results - "Glaser, K B"

Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway by Zhou, J, Pan, M, Xie, Z, Loh, S-L, Bi, C, Tai, Y-C, Lilly, M, Lim, Y-P, Han, J-H, Glaser, K B, Albert, D H, Davidsen, S K, Chen, C-S

“…Internal tandem duplications (ITDs) of fms-like tyrosine kinase 3 (FLT3) receptor play an important role in the pathogenesis of acute myeloid leukemia (AML)…”
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Differential protein acetylation induced by novel histone deacetylase inhibitors by Glaser, K.B., Li, J., Pease, L.J., Staver, M.J., Marcotte, P.A., Guo, J., Frey, R.R., Garland, R.B., Heyman, H.R., Wada, C.K., Vasudevan, A., Michaelides, M.R., Davidsen, S.K., Curtin, M.L.

“…Histone deacetylase (HDAC) inhibitors induce the hyperacetylation of nucleosomal histones in carcinoma cells resulting in the expression of repressed genes…”
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Phospholipase A2 enzymes: regulation and inhibition by Glaser, K B, Mobilio, D, Chang, J Y, Senko, N

“…The phospholipase A2 enzymes are important components of the cellular machinery that responds to inflammatory stimuli and maintains cell homeostasis by…”
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Lipopolysaccharide Induces Hyporesponsiveness to Its Own Action in RAW 264.7 Cells by Virca, G D, Kim, S Y, Glaser, K B, Ulevitch, R J

“…Bacterial endotoxin (lipopolysaccharide, LPS) has the property of inducing hyporesponsiveness or tolerance to its own effects. This phenomenon has been…”
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Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2 by GLASER, K. B, ASMIS, R, DENNIS, E. A

“…P388D1 cells are stimulated by platelet-activating factor (PAF) to release arachidonic acid metabolites (Lister, M. D., Glaser, K. B., Ulevitch, R. J., and…”
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Inhibition of Aurora B kinase sensitizes a subset of human glioma cells to TRAIL concomitant with induction of TRAIL-R2 by Li, J, Anderson, M G, Tucker, L A, Shen, Y, Glaser, K B, Shah, O J

“…Small-molecule inhibitors of the Aurora A and B kinases interfere with mitotic centrosome function and disrupt the mitotic spindle assembly checkpoint…”
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Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2 by Mayer, A M, Brenic, S, Glaser, K B

“…The purpose of this investigation was to pharmacologically probe the signaling pathways thought to be involved in protein kinase C (PKC)-stimulated superoxide…”
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Energy value of resistant starch by Ranhotra, G.S. (American Institute of Baking, Manhattan, KS.), Gelroth, J.A, Glaser, B.K

“…ABSTRACT Resistant starch was evaluated for energy value using fine silica and normal starch as controls and young rats as a test model. The net increase in…”
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Regulation of eicosanoid biosynthesis in the macrophage. Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors by Glaser, K B, Sung, A, Bauer, J, Weichman, B M

“…The protein tyrosine kinase (PTK) inhibitor genistein has been demonstrated to inhibit platelet-activating factor-stimulated prostaglandin E2 (PGE2) production…”
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Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation by Glaser, K B, de Carvalho, M S, Jacobs, R S, Kernan, M R, Faulkner, D J

“…Manoalide is a potent antiinflammatory marine natural product and a direct inactivator of venom phospholipase A2 (PLA2; EC 3.1.1.4). Manoalide has been shown…”
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Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA by Glaser, Keith B, Li, Junling, Staver, Michael J, Wei, Ru-Qi, Albert, Daniel H, Davidsen, Steven K

“…The role of the individual histone deacetylases (HDACs) in the regulation of cancer cell proliferation was investigated using siRNA-mediated protein knockdown…”
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Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide by LISTER, M. D, GLASER, K. B, ULEVITCH, R. J, DENNIS, E. A

“…In order to ascertain the role of phospholipase A2 (PLA2) in the release of arachidonic acid for eicosanoid biosynthesis, we have characterized a…”
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Identification of genes that confer tumor cell resistance to the Aurora B kinase inhibitor, AZD1152 by Guo, J, Anderson, M G, Tapang, P, Palma, J P, Rodriguez, L E, Niquette, A, Li, J, Bouska, J J, Wang, G, Semizarov, D, Albert, D H, Donawho, C K, Glaser, K B, Shah, O J

“…AZD1152 is a highly selective Aurora B kinase inhibitor currently undergoing Phase I and II clinical evaluation in patients with acute myelogenous leukemia and…”
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Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s) by Mayer, A M, Brenic, S, Stocker, R, Glaser, K B

“…Ninety minutes after i.v. injection of Escherichia coli lipopolysaccharide (LPS) (1 mg/kg) into rats, phorbol 12-myristate 13-acetate (PMA)-stimulated…”
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Baking and nutritional qualities of a spelt wheat sample by Ranhotra, G.S., Gelroth, J.A., Glaser, B.K., Lorenz, K.J.

“…Flours from a sample of hard red winter (HRW) wheat and spelt wheat were evaluated for milling, baking and nutritional qualities, Milling flour yield from the…”
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Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial: Novel effects independent of inhibition of lipid mediator production by Glaser, Keith B., Lock, Yeung Wai

“…The marine natural products manoalide and scalaradial are potent anti-inflammatory agents that inactivate the enzyme phospholipase A 2 (PLA 2) in vitro. To…”
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Nutritional profile of three spelt wheat cultivars grown at five different locations by Ranhotra, G.S. (American Institute of Baking, Manhattan, KS.), Gelroth, J.A, Glaser, B.K, Stallknecht, G.F

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Sirolimus (rapamycin, Rapamune) and combination therapy with cyclosporin A in the rat developing adjuvant arthritis model: correlation with blood levels and the effects of different oral formulations by Carlson, R P, Hartman, D A, Ochalski, S J, Zimmerman, J L, Glaser, K B

“…To determine whole blood levels of sirolimus, a macrolide antibiotic in the rat developing adjuvant arthritis (AA) model after dosing orally with two different…”
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Molecular pharmacology of manoalide. Inactivation of bee venom phospholipase A2 by Glaser, K B, Jacobs, R S

“…The marine natural product manoalide (MLD) was shown to directly inactivate bee venom phospholipase A2 (PLA2). Inactivation was pH dependent (maximum…”
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Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats by Ranhotra, G.S. (American Inst. of Baking, Manhattan, KS (USA).), Gelroth, J.A, Glaser, B.K, Schoening, P, Brown, S.E

“…In a 30-week preliminary study and a follow-up 22-week study (2 x 2 factorial), dimethylhydrazine (DMH) injections effectively induced colon tumors in…”
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